Pathology of Cardiac Xenograft Rejection
Rejection of cardiac xenografts between closely related species may be exclusively acute (cellular) (e.g. Cynomolgus monkey to baboon) or it may be due to a mixture of vascular (hyperacute or delayed vascular/humoral-mediated) and acute rejection (e.g. vervet monkey to baboon). Rejection of xenografts between distantly related species (e.g. pig to baboon) is always by a hyperacute mechanism in the untreated model. Though the acute response can be delayed, or even prevented, by currently available immunosuppressive agents and techniques, hyperacute rejection (Figures 1-7) has proved extremely difficult to prevent or delay. Cardiac xenografts have very occasionally been used in humans in a desperate attempt to save the life of a patient for whom no human donor heart was available’ (Chapter 82). Xenogeneic (and allogeneic in sensitized hosts) cardiac transplants, which have been performed in a wide range of experimental animals, have helped to further our understanding of the mechanism of hyperacute rejection’ (Chapter 80).
KeywordsAcute Rejection Cardiac Allograft Acute Cellular Rejection Hyperacute Rejection Cardiac Allograft Rejection
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