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Maintenance Immunosuppressive Drug Therapy and Potential Major Complications

  • K. L. Tyndall
  • D. K. C. Cooper

Abstract

The various pharmacological immunosuppressive agents available to those involved in organ transplantation have been discussed by a number of authors, and detailed accounts of their structure and mode of action can be found elsewhere. A comprehensive review of the newer agents presently in early clinical use, or in clinical or experimental development, is presented elsewhere in this volume (Chapter 70). The vast majority of centers today, however, utilize triple-drug maintenance therapy with cyclosporin (CsA), azathioprine (AZA), and corticosteroids. CsA-Neoral is beginning to take the place of CsA, and will eventually supersede it. Tacrolimus (FK506) has been introduced in place of CsA in a few centers (Chapters 10 and 70). (It is important to note that CsA and tacrolimus should not be given in combination, due to their severe nephrotoxic effect.) Cyclophosphamide is sometimes used to replace AZA, and mycophenolate mofetil is beginning to replace AZA in a small number of centers (Chapter 70). In addition, some centers include induction cytolytic therapy with an anti-T-cell polyclonal (an antithymocyte (ATG)/antilymphocyte (ALG) globulin) or monoclonal (OKT3) antibody.

Keywords

Transplant Patient Acute Rejection Transplant Proc Heart Transplant Recipient Heart Lung Transplant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • K. L. Tyndall
  • D. K. C. Cooper

There are no affiliations available

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