Gene Transfer

  • A. Ardehali
  • H. Laks
  • A. Fyfe


Major advances in recombinant DNA technology have remarkably improved our understanding of gene expression, and heralded new therapies for inherited and acquired diseases. This progress is especially notable considering that the structural unit of the human genome was discovered only 50 years ago. Recent studies have successfully introduced foreign DNA sequences into the vessel wall of multiple experimental animals, using a variety of vectors[1]’[7]. These studies have stimulated hope that this technology may be used to revolutionize the practice of cardiovascular medicine. Instead of using empiric observations to form the basis of medical therapy, insight into the genetic mechanisms of disease can allow a directed approach to medical therapy. Extension of gene transfer technology to the field of solid-organ transplantation is in its infancy; however, it holds great promise in the future.


Gene Transfer Adenoviral Vector Cationic Liposome Donor Heart Direct Gene Transfer 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • A. Ardehali
  • H. Laks
  • A. Fyfe

There are no affiliations available

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