Immunomodulation with Photopheresis
Modern immunosuppressive regimens utilizing cyclosporin or tacrolimus (FK506), azathioprine or mycophenolate mofetil, and corticosteroids, with or without induction protocols using monoclonal or polyclonal antibodies, have resulted in dramatically increased survival of transplanted organs. However, in addition to suppressing the immune response to the allograft, they impair immune function in a non-specific and often toxic fashion, leaving the host susceptible to increased risk of opportunistic infections, malignancy, and the direct side-effects of these drugs. Moreover, there remain significant morbidity and mortality from organ rejection in the form of acute episodes, as well as chronic forms as seen in late-onset progressive graft failure such as transplant coronary disease.
KeywordsMycophenolate Mofetil Heart Transplant Recipient Acute Cellular Rejection Heart Lung Transplant Mixed Lymphocyte Culture
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