Pulmonary Retransplantation for Obliterative Bronchiolitis
Despite increasing experience in the postoperative care of lung transplant recipients, obliterative bronchiolitis (OB) develops in up to 40% of patients in the intermediate term postoperatively,. Although some patients with this condition respond to increased immunosuppression,, in many others chronic allograft dysfunction is resistant to therapy and ultimately causes death from progressive respiratory failure or opportunistic infection. Since 1988 an increasing number of lung transplant recipients with OB have been treated by retransplantation,. The pulmonary retransplant registry was established in 1991 in order to document the results and determine the predictors of survival after pulmonary retransplantation,. Recently, after increased patient accrual, the registry data were updated in order to document the determinants of outcome after retransplantation for OB.
KeywordsLung Transplantation Actuarial Survival Bronchiolitis Obliterans Syndrome Lung Transplant Recipient Heart Lung Transplant
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Cooper JD, Patterson GA, Trulock EP, Washington University Lung Transplant Group. Results of single and bilateral lung transplantation in 131 consecutive recipients. J Thorac Cardiovasc Surg. 1994;107:460–71.PubMedGoogle Scholar
Egan TM, Detterbeck FC, Mill MR et al.
Improved results of lung transplantation for patienls with cystic fibrosis. J Thorac Cardiovasc Surg. 1995;109:224–35.PubMedCrossRefGoogle Scholar
Glanville AR, Baldwin JC, Burke CM, Theodore J, Robin ED. Obliterative bronchiolitis after heart-lung transplantation: apparent arrest by augmented immunosuppression. Ann Intern Med. 1987;107:300–4.PubMedGoogle Scholar
Miller JD, Patterson GA. Retransplantation following isolated lung transplantation. Semin Thorac Cardiovasc Surg. 1992;4:122–5.PubMedGoogle Scholar
Novick RJ, Kaye MP, Patterson GA et al.
Redo lung transplantation: a North American-Kuropean experience. J Heart Lung Transplant. 1993;12:5–16PubMedGoogle Scholar
Shennib H, Novick R, Mulder D et al.
Is lung retransplantation indicated? Report on tour patients. Eur Respir J. 1993;6:354–7.PubMedGoogle Scholar
Bjortuft O, Forester A, Boe J, Geiran O, Single lung transplantation as treatment for end-stage pulmonary sarcoidosis: recurrence of sarcoidosis in two different lung allografts in one patient. J Heart Lung Transplant. 1994;13:24–9.PubMedGoogle Scholar
Fournier M, Sleiman C, Mal H et al.
Single-lung retransplantation for late graft failure. Eur Respir J. 1993;6:1202–6.PubMedGoogle Scholar
Adams DH, Cochrane AD, Khaghani A, Smith JD, Vacoub MH. Retransplantation in heart-lung recipients with obliterative bronchiolitis. J Thorac Cardiovasc Surg. 1994;107:450–9.PubMedGoogle Scholar
Haverich A, Hirt SW, Wahlers T, Schafers HJ, Zink C, Borst HG, Functional results after lung retransplantation. J Heart Lung Transplant. 1994;13:48–55.PubMedGoogle Scholar
Novick RJ, Andreassian B, Schafers HJ et al.
Pulmonary retransplantation for obliterative bronchiolitis: intermediate-term results of a North American-European series. J Thorac Cardiovasc Surg. 1994;107:755–63.PubMedGoogle Scholar
Schafers HJ, Hausen B, Wahlers T, Fieguth HG, Jurmann M, Borst HG. Retransplantation of the lung: a single center experience. Eur J Cardiothor Surg. 1995;9:291–6.CrossRefGoogle Scholar
Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1957;53:457–81.CrossRefGoogle Scholar
Gehan EA. A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biometrika. 1965;52:203–23.PubMedGoogle Scholar
Cox DR. Regression models and life-tables. J R Stat Soc Ser B. 1972;34:187–220.Google Scholar
Cooper JD, Billingham M, Hgan T et al.
A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. J Heart Lung Transplant. 1993;12:713–16.PubMedGoogle Scholar
Zeevi A, Rabinowich H, Yousem SA et al.
Presence of donor-specific alloreactivity in histologically normal lung allografts is predictive of subsequent bronchiolitis obliterans. Transplant Proc. 1991;23:1128–9.PubMedGoogle Scholar
Yousem SA, Sartori D, Sonmez-Alpan H. Multidrug resistance in lung allograft recipients: possible correlation with the development of acute and chronic rejection. J Heart Lung Transplant. 1993:12:20–6.PubMedGoogle Scholar
Hausen B, Dwenger A, Gohrbandt B et al.
Early biochemical indicators of the obliterative bronchiolitis syndrome in lung transplantation. J Heart Lung Transplant. 1994;13:980–9.PubMedGoogle Scholar
Milne DS, Oascoigne AD, Wilkes J et al.
MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients. Transplantation. 1994;57:1762–6.PubMedGoogle Scholar
McCarthy PM, Starnes VA, Theodore J, Stinson EB, Over PH, Shumway NH. Improved survival after heart-lung transplantation. J Thorac Cardiovasc Surg. 1990;99:54–60.PubMedGoogle Scholar
Edwards FH, Clark RE, Schwartz M. Practical considerations in the management of large multiinstitutional databases. Ann Thorac Surg. 1994;58:1841–4.PubMedCrossRefGoogle Scholar
Dauber JH, Paradis IL, Dummer JS. Infectious complications in pulmonary allograft recipients. Clin Chest Med. 1990;11:291–308.PubMedGoogle Scholar
Cooper JD, St. Louis International Lung Transplant Registry. September 1994 Report. St. Louis. MO.Google Scholar
Flume PA, Egan TM, Westerman JH et al.
Lung transplantation for mechanically ventilated patients. J Heart Lung Transplant 1994;13:15–21.PubMedGoogle Scholar
Mentzer SJ, Reilly JJ, Caplan AL, Sugarbaker DJ, Ethical considerations in lung retransplantation. J Heart Lung Transplant. 1994;13:56–8.PubMedGoogle Scholar
© Kluwer Academic Publishers 1996