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Diagnosis and Management of Bronchiolitis Obliterans

  • M. Kriett
  • S. W. Jamieson

Abstract

The most common cause of late death after lung transplantation has been a progressive and unrelenting deterioration in pulmonary allograft function related to the development of obliterative airway disease. In the transplantation literature this entity has been referred to as bronchiolitis obliterans, obliterative bronchiolitis, chronic rejection and, most recently, bronchiolitis obliterans syndrome. Although the etiology of bronchiolitis obliterans remains unclear, it most likely represents a manifestation of chronic lung rejection. The current approaches to the diagnosis and management of bronchiolitis obliterans are reviewed below.

Keywords

Acute Rejection Bronchiolitis Obliterans Bronchiolitis Obliterans Syndrome Lung Transplant Recipient Lung Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Veith FJ, Montefusco C, Kamholz SL, Mollenkopf FP. Lung transplantation. J Heart Transplant. 1983;2:155.Google Scholar
  2. 2.
    Derom F, Barbier F, Ringoir S et al. Ten-month survival after lung homotransplantation in man. J Thorac Cardiovasc Surg. 1971;61:835.PubMedGoogle Scholar
  3. 3.
    Burke CM, Theodore J, Dawkins KD et al. Post-transplant oblitcrative bronchiolitis and other late lung sequelae in human heart-lung transplantation. Chest. 1984;86:824.PubMedGoogle Scholar
  4. 4.
    Dawkins KD, Jamieson SW, Hunt SA et al. Long-term results, hemodynamies and complications after combined heart and lung transplantation. Circulation. 1985;71:912.Google Scholar
  5. 5.
    Burke CM, Morris AJR, Dawkins KD et al. Late airflow obstruction in heart lung transplantation recipients. J Heart Transplant. 1985;4:437.PubMedGoogle Scholar
  6. 6.
    Yousem SA, Burke CM, Billingham ME. Pathologic pulmonary alterations in long-term human heart-lung transplantation. Human Pathol. 1985:16:911.CrossRefGoogle Scholar
  7. 7.
    Burke CM, Morris AJ, Dawkins KD et al. Obliterative bronchiolitis and chronic pulmonary rejection. J Heart Transplant. 1985;4:144.Google Scholar
  8. 8.
    Jamieson SW, Dawkins KD, Burke C et al. Late results of combined heart-lung transplantation. Transplant Proc. 1985;17:212.Google Scholar
  9. 9.
    Burke CM, Baldwin JC, Morris AJ et al. Twenty-eight cases of human heart-lung transplantation. Lancet. 1987;1:517.Google Scholar
  10. 10.
    Allen MD, Burke CM, McGregor CGA, Baldwin JC, Jamieson SW, Theodore J. Steroid-responsive bronchiolitis after human heart-lung transplantation. J Thorac Cardiovasc Surg. 1986;92:449.PubMedGoogle Scholar
  11. 11.
    Glanville AR, Baldwin JC, Burke CM, Theodore J, Robin ED. Oblilerative bronchiolitis after heart-lung transplantation: apparent arrest by augmented immunosuppression. Ann Intern Med. 1987;107:300.PubMedGoogle Scholar
  12. 12.
    Cooper JD, Billingham M, Egan T et al. A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. J Heart Lung Transplant. 1993;12:713.PubMedGoogle Scholar
  13. 13.
    Griffith BP, Paradis IL, Zeevi A et al. Immunologically mediated disease of airways after pulmonary transplantation. Ann Surg. 1988;208:371.PubMedCrossRefGoogle Scholar
  14. 14.
    McCarthy P. Starnes VA, Theodore J. Stinson KB, Over PE, Shumway NE. Improved survival following heart-lung transplantation. J Thorac Cardiovasc Surg. 1990;99:54.PubMedGoogle Scholar
  15. 15.
    Scott JP, Higgenbottam TW, Clelland CA et al. Natural history of chronic rejection in heart-lung transplant recipients. J Heart Transplant. 1990;9:510.PubMedGoogle Scholar
  16. 16.
    Madden BP, Hodson ME, Tsang V, Radley-Smith R, Khagani A, Yacouh MY, Intermediate-term results of heart-lung transplantation for cystic fibrosis Lancet. 1992;339:1583.PubMedCrossRefGoogle Scholar
  17. 17.
    Wahlers T, Haverich A, Schafers HJ et al. Chronic rejection following lung transplantation. Incidence, time pattern and consequences. Eur J Cardiothorac Surg 1993;7:319.PubMedCrossRefGoogle Scholar
  18. 18.
    Paradis IL, Yousem SA, Griffith BP. Airway obstruction and bronchiolitis obliterans after lung transplantation. Clin Chest Med. 1993;4:751.Google Scholar
  19. 19.
    Cooper JD, Patterson GA, Trulock EP. Results of single and bilateral king transplantation in 131 consecutive recipients. Washington University Lung Transplant Group. J Thorac Cardiovasc Surg. 1994;107:460.PubMedGoogle Scholar
  20. 20.
    Whitehead B, Rees P, Sorenson K et al. Incidence of obliterative bronchiolitis after heart-lung transplantation in children. Transplantation. 1994;56:956.Google Scholar
  21. 21.
    Sarris GE, Smith JA, Shumway NE et al. Long-term results of combined heart-lung transplantation: the Stanford experience. J Heart Lung Transplant. 1994;13:940PubMedGoogle Scholar
  22. 22.
    Egan TM, Detterbeck FC, Mill MR et al. Improved results of lung transplantation for patients with cystic fibrosis. J Thorac Cardiovasc Surg. 1995;109:224PubMedCrossRefGoogle Scholar
  23. 23.
    Kriett JM, Kaye MP. The Registry of the International Society for Heart and Lung Transplantation: Eighth official report-1991. J Heart Lung Transplant. 1991;10:491.PubMedGoogle Scholar
  24. 24.
    Chapparo C, Maurer JR, Chamberlain D et al. Causes of death in lung transplant recipients. J Heart Lung Transplant. 1994;13:758.Google Scholar
  25. 25.
    Bando K, Paradis IL, Komatsu K et al. Analysis of time-dependent risks for infection, rejection, and death after pulmonary transplantation. J Thorac Cardiovasc Surg. 1995;109:49.PubMedCrossRefGoogle Scholar
  26. 26.
    Epler G, Colby T. The spectrum of bronchiolitis obliterans. Chest. 1983:83:161.PubMedGoogle Scholar
  27. 27.
    Ezri T, Kunichczky S, Eliraz A, Soroker D, Halperin D, Schattner A, Bronchiolitis oblilerans-current concepts. QJ Med. 1994;87:1.Google Scholar
  28. 28.
    Wyall SE, Nunn P, Howes JM et al. Airways obstruction associated with graft-versus-host disease after bone marrow transplantation. Thorax. 1984;39:887.CrossRefGoogle Scholar
  29. 29.
    Paradis IL, Marrai M, Zeevi A et al. The transition of lung lavage cells from donor to recipient phenotype after heart-lung transplantation. J Heart Transplant. 1985;4:138.Google Scholar
  30. 30.
    Cohen RG, Hoyt EG, Billingham ME, Bieber CP, Jamieson SW, and Shumway NE. Myocardial fibrosis due to cyclosporin in rat heterotopic heart transplantation. Heart Transplant. 1984;3:355.Google Scholar
  31. 31.
    Castaneda AR, Zamora R, Schmidt-Habelman P et al. Cardiopulmonary autotransplantation in primates (baboons): late functional results. Surgery. 1972;72:1064.PubMedGoogle Scholar
  32. 32.
    Haverich A, Dawkins KD, Baldwin JC, Reitz BA. Billingham ME, Jamieson SW. Long-term cardiac and pulmonary histology in primates following combined heart and lung transplantation. Transplantation. 1985;39:356.PubMedCrossRefGoogle Scholar
  33. 33.
    Dawkins KD, Haverich A, Derby GC et al. Long-term hemodynamics following combined heart and lung transplantation in primates. J Thorac Cardiovasc Surg. 1985;89:55.PubMedGoogle Scholar
  34. 34.
    Gurzon AA, Goldstein S, Okadigwe CI, Paley NB, Minkowitz S. Hypothermic lung preservation functions, six or more years later. Ann Surg. 1977;186:711.Google Scholar
  35. 35.
    Hino K, Grogan JB, Hardy JD. Viability of stored lungs. Transplantation. 1968;6:25.PubMedCrossRefGoogle Scholar
  36. 36.
    Tazelaar HD, Prop J. Nieuwenhuis P, Billingham ME, Wildevuur CRH. Obliterative bronchiolitis in the transplanted rat lung. Transplant Proc. 1987;19:1052.PubMedGoogle Scholar
  37. 37.
    Taylor P, Rose M, Yacoub M. Expression of MHC antigens in normal lungs and transplanted lungs with obliterative bronchiolitis. Transplantation. 1989;48:506.PubMedCrossRefGoogle Scholar
  38. 38.
    Reinsmoen NL, Bolman RM, Savik K, Butters K, Hertz MI. Are multiple immunopathogenetic events occurring during the development of obliterative bronchiolitis and acute rejection? Transplantation. 1993;55:1040.PubMedGoogle Scholar
  39. 39.
    al-Dossari GA, Kshettry VR, Jessurun J, Bolman RM, Experimental large-animal model of obliterative bronchiolitis after lung transplantation. Ann Thorac Surg. 1994;58:34.PubMedGoogle Scholar
  40. 40.
    Fattal-German M, Franchon I, Cerrina J, Ladurie FL, Lecerf F, Dartevelle P. Berrih-Aknin S. Particular phenotypic profile of blood lymphocytes during obliterative bronchiolitis syndrome following lung transplantation. Transplant Immunol. 1994;2:243.CrossRefGoogle Scholar
  41. 41.
    Keenan R, Decvi A, Banas R et al. Micro-chimerism is associated with a lower incidence of chronic rejection after lung transplantation. J Heart Lung Transplant. 1994;13:S32.Google Scholar
  42. 42.
    Reinsmoen NL, Bolman RM, Savik K, Butters K, Matas AJ. Hertz MI, Improved long-term graft outcome in lung transplant recipients who have donor antigen-specific hyporeactivity. J Heart Lung Transplant. 1994:13:30.PubMedGoogle Scholar
  43. 43.
    Scott JP, Higenbottam TW, Sharples L et al. Risk factors for obliterative bronchiolitis in heart-lung transplant recipients. Transplantation. 1991:51:813.PubMedCrossRefGoogle Scholar
  44. 44.
    Milne DS, Gaseoigne AD, Ashcroft T, Sviland L, Malcolm AJ, Corris PA. Organizing pneumonia following pulmonary transplantation and the development of obliterative bronchiolitis. Transplantation. 1994:57:1757.PubMedGoogle Scholar
  45. 45.
    Winter JB, Gouw AS, Groen M, Wildevuur C, Prop J. Respiratory viral infections aggravate airway damage caused by chronic rejection in rat lung allografts. Transplantation. 1994;57:418.PubMedCrossRefGoogle Scholar
  46. 46.
    Keenan RJ, Lega ME, Dummer JH et al Cytomegalovirus serological status and postoperative infection correlated with risk of developing chronic rejection after pulmonary transplantation. Transplantation. 1991;51:433.PubMedCrossRefGoogle Scholar
  47. 47.
    Keenan RJ, Zeevi A. Immunnlogic consequences of transplantation. Chest Surg Clin. 1995;5:107.Google Scholar
  48. 48.
    Theodore J, Jamieson SW, Burke CM et al. Physiological aspects of human heart-lung transplantation: pulmonary function status of the post-transplanted lung. Chest. 1984;86:349.PubMedGoogle Scholar
  49. 49.
    Theodore J, Marshall S, Kramer M, Duncan S, Lewiston N. Starnes V. The ‘natural history’ of the transplanted lung: rates of pulmonary functional change in long-term survivors of heart-lung transplantation. Transplant Proc. 1991;23:1165.PubMedGoogle Scholar
  50. 50.
    Williams TJ, Grossman RF, Maurer JR. Long-term functional follow-up of lung transplant recipients. Clin Chest Med. 1990;11:347.PubMedGoogle Scholar
  51. 51.
    Morrish W, Herman S, Weisbrod GL, Chamberlain DW. Bronchiolitis obliterans after lung transplantation: findings at chest radiography and high-resolution CT. Radiology. 1991;179:487.PubMedGoogle Scholar
  52. 52.
    Lentz D, Bergin CJ, Berry GJ, Stoehr C, Theodore J. Diagnosis of bronchiolitis obliterans in heart-lung transplantation patients: importance of bronchial dilatation on CT. Am J Roenterol. 1992;159:463.Google Scholar
  53. 53.
    Medina S, Seigel MJ. CT of complications in pediatric lung transplantation. Radiographics. 1994;14:1341.PubMedGoogle Scholar
  54. 54.
    Loubeyre P, Revel D, Delignette A, et al. Bronchiectasis detected with thin-section CT as a predictor of chronic lung allograft rejection. Radiology. 1995;194:213.PubMedGoogle Scholar
  55. 55.
    Kramer MR, Stoehr C, Whang JL et al. The diagnosis of obliterative bronchiolitis after heart-lung and lung transplantation: low yield of transbronehial lung biopsy. J Heart Transplant. 1993;12:675.Google Scholar
  56. 56.
    Yousem SA, Paradis I, Griffith BP. Can transbronehial biopsy aid in the diagnosis of bronchiolitis obliterans in lung transplant recipients? Transplantation. 1993;57:151.Google Scholar
  57. 57.
    Ohori NP, Iacono AT, Grgurich WF, Yousem SA. Significance of acute bronchitis/bronchiolitis in the lung transplant recipient. Am J Surg Pathol. 1994;18:1192.PubMedGoogle Scholar
  58. 58.
    Duquesnoy RJ and Zeevi A. Immunological monitoring of lung transplant recipients by bronchoalveolar lavage analysis. Transplant Rev. 1992;6:218Google Scholar
  59. 59.
    Novick RJ, Andreassian B, Schafers HJ et al. Pulmonary retransplantation for obliterative bronchiolitis. Intermediate-term result of a North American-European series. J Thorac Cardiovasc Surg, 1994;107:755.PubMedGoogle Scholar
  60. 60.
    Adams DH, Cochrane AD, Khagani A, Smith JD, Yacoub MH. Retransplantation in heart-lung recipients with obliterative bronchiolitis. J Thorac Cardiovasc Surg. 1994;107:450.Google Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • M. Kriett
  • S. W. Jamieson

There are no affiliations available

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