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Infection After Lung Transplantation

  • I.L Paradis

Abstract

Infection remains the most common cause of morbidity and mortality after lung transplantation (LTx)[1]’[3]. Of the 402 lung allograft procedures that were performed in 386 recipients at the University of Pittsburgh between 1982 and 1 July 1995, 187 allografts (47%) in 180 recipients (47%) failed (Table 1). Because some infections were due to more than one type of organism (e.g. bacteria plus Aspergillus), 115 infectious organisms were responsible for the failure of 97 (52%) allografts in 86 (48%) recipients that failed primarily due to infection. However, since 1989, infection has declined significantly from 46% to 32% as an etiology, from 80% to 53% as a cause of allograft failure, and from 85% to 54% as a cause of recipient death. This occurred because of the cumulative effect of a small decline in the prevalence of each type of infectious organism as a cause of allograft failure. Because infection has been the primary cause of failure in 53-54% of the grafts that have failed since 1989, it still remains the principal and unacceptable cause of allograft failure and death after LTx.

Keywords

Acute Rejection Lung Transplantation None None Chronic Rejection Obliterative Bronchiolitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Kluwer Academic Publishers 1996

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  • I.L Paradis

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