Selection and Evaluation of the Potential Thoracic Organ Transplant Recipient - General Considerations

  • D. K. C. Cooper
  • N. K. Imes
  • D. P. Nelson


Selection of appropriate recipients for heart or lung transplantation may be the most important factor determining long-term survival, yet selection remains difficult and guidelines vary to some extent from one institution to another[1]–[3]. With increasing experience and success, there has been a relaxation in selection criteria in heart transplant candidates, with both older and younger patients and insulin-requiring diabetics now being offered transplantation. Similarly, with increasing experience in lung transplantation, selection criteria are gradually being modified. Greater experience with the new immunosuppressive regimens that are steadily becoming available, including tacrolimus (FK506) and mycophenolate mofetil, is likely to further broaden the criteria for transplantation.


Cystic Fibrosis Heart Transplant Donor Organ Lung Transplantation Primary Pulmonary Hypertension 
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  1. 1.
    Mudge GH, Goldstein S, Addonizio LJ et al. Cardiac Transplantation Task Force 3: Recipient guidelines/prioritization. 24th Bethesda Conference, 1992. J Am Coll Cardiol. 1993;22:21.PubMedCrossRefGoogle Scholar
  2. 2.
    Marshall SE, Kramer MR, Lewiston NJ et al. Selection and evaluation of recipients for heart-lung and lung transplantation. Chest. 1990;98:1488.PubMedGoogle Scholar
  3. 3.
    Egan TM, Trulock EP, Boychuk J et al. Analysis of referrals for lung transplantation. Chest. 1991;99:867.PubMedGoogle Scholar
  4. 4.
    Muchmore JS, Cooper DKC, Ye Y et al. Prevention of loss of vertebral bone density in heart transplant patients. J Heart Lung Transplant. 1992;11:959.PubMedGoogle Scholar
  5. 5.
    Lower RR, Szentpetery S, Quinn J, Thomas FT. Selection of patients for cardiac transplantation. Transplant Proc. 1979;11:293.PubMedGoogle Scholar
  6. 6.
    Oyer PE, Stinson EB, Bieber CP, Shumway NE. Cardiac transplantation. In Chatterjee, SN, editor. Organ transplantation. Boston: P.S.G. Wright: 1982;347.Google Scholar
  7. 7.
    Cooper DKC, Charles RG, Beck W, Barnard CN. The assessment and selection of patients for heterotopic heart transplantation. S Afr Med J. 1982;61:575.PubMedGoogle Scholar
  8. 8.
    Thompson ME. Selection of candidates for cardiac transplantation. J Heart Transplant. 1983;3:65.Google Scholar
  9. 9.
    Cooper DKC, Lanza RP, Boyd ST, Barnard CN. Factors influencing survival following heart transplantation. J Heart Transplant. 1983;3:86.Google Scholar
  10. 10.
    Copeland JG, Emery RW, Levinson MM et al. Selection of patients for cardiac transplantation. Circulation. 1987;75:1.Google Scholar
  11. 11.
    Paradis IL, Manzetti J. Medical evaluation for lung transplantation. Sem Anesthesia. 1995;14:110.Google Scholar
  12. 12.
    Kramer MR, Tiroke A, Marshall SE et al. The clinical significance of hyperbilirubenemia in patients with pulmonary hypertension undergoing heart-lung transplants. J Heart Transplant. 1990;9:79A (abstract).Google Scholar
  13. 13.
    Copeland JG, Mammana RB, Fuller JK et al. Heart transplantation; four years experience with conventional immunosuppression. J Am Med Assoc. 1984;125:1563.CrossRefGoogle Scholar
  14. 14.
    Carrier M, Emery RW, Riley JE, Levinson MM, Copeland JG. Cardiac transplantation in patients over 50 years of age. J Am Coll Cardiol. 1986;8:285.PubMedCrossRefGoogle Scholar
  15. 15.
    Miller LW, Pennington DG, Kanter K, McBride L. Heart transplantation in patients over 55 years of age. J Heart Transplant. 1986;5:367.Google Scholar
  16. 16.
    Olivari M, Antolick A, Kaye M, Jamieson S, Ring WS. Heart transplantation in elderly patients. J Heart Transplant. 1988;7:258.PubMedGoogle Scholar
  17. 17.
    Mischke L, Sisson S, Cooper DKC, Zuhdi N. Cardiac transplantation in patients age 60 years or older. J Okla State Med Assoc. (In press).Google Scholar
  18. 18.
    Renlund DG, Gilbert EM, O’Connell JB et al. Age-associated decline in cardiac allograft rejection. Am J Med. 1987;83:391.PubMedCrossRefGoogle Scholar
  19. 19.
    Mann GU. The influence of obesity on health. N Engl J Med. 1974;291:178, 226.PubMedCrossRefGoogle Scholar
  20. 20.
    Pasulka PS, Bistrian BR, Benotti PN et al. The risks of surgery in obese patients. Ann Intern Med. 1986;104:540.PubMedGoogle Scholar
  21. 21.
    Low DE, Trulock EP, Kaiser LR et al. Lung transplantation of ventilator-dependent patients. Chest. 1992;101:8.PubMedGoogle Scholar
  22. 22.
    Caplan AL, Equity in the selection of recipients for cardiac transplants. Circulation. 1987;75:10.PubMedGoogle Scholar
  23. 23.
    Robertson JA. Supply and distribution of hearts for transplantation: legal, ethical and policy issues. Circulation. 1987;75:81.Google Scholar
  24. 24.
    Holland C, Hagan M, Volkman K et al. Substance abuse: does this warrant exclusion for transplant? J Heart Transplant. 1988;7:70 (abstract).Google Scholar
  25. 25.
    Benowitz NL. Pharmacologic aspects of cigarette smoking and nicotine addiction. N Engl J Med. 1988;319:1318.PubMedCrossRefGoogle Scholar
  26. 26.
    Cooper DKC, Lanza RP, Barnard CN. Non-compliance in heart transplant recipients: the Cape Town experience. J Heart Transplant. 1984;3:248.Google Scholar
  27. 27.
    Rovelli M, Palmeri D, Vossler E et al. Non-compliance in organ transplant recipients. Transplant Proc. 1989;21:833.PubMedGoogle Scholar
  28. 28.
    Rodriguez MD, Colon A, Santiago-Delpin EA. Psychosocial profile of noncompliant patients. Transplant Proc. 1991;23:1807.PubMedGoogle Scholar

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© Kluwer Academic Publishers 1996

Authors and Affiliations

  • D. K. C. Cooper
  • N. K. Imes
  • D. P. Nelson

There are no affiliations available

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