Indications, Selection and Pretransplant Management of the Potential Recipient

  • J. R. Maurer


Since the first edition of this textbook, technical advances in surgical approach and intraoperative management, combined with increasing experience in medical care of transplant recipients, have led to much-improved outcomes for lung transplant recipients. This increased experience in the care of the recipients has led both to changes in indications for specific surgeries and to improved criteria for choosing appropriate transplant candidates.


Cystic Fibrosis Pulmonary Hypertension Idiopathic Pulmonary Fibrosis Lung Transplant Cystic Fibrosis Patient 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 2.
    Shennib H, Massard G, Gauthier R, Colman N, Mulder D. and the Cystic Fibrosis Transplant Study Group. Single lung transplantation for cystic fibrosis: is it un option? J Heart Lung Transplant. 1993;12:288.PubMedGoogle Scholar
  2. 3.
    Forty J, Hasan A, Gould FK, Corris PA, Dark JH. Single lung transplantation with simultaneous contracteral pneumonectomy for cystic fibrosis. J Heart Lung Transplant. 1994;13:727.PubMedGoogle Scholar
  3. 4.
    Miralles A, Kawaguchi A, Gandjbakhch I et al. Heart and unilateral lung transplantation in patients with end-stage cardiopulmonary disease and previous thoracic surgery. Transplant Proc. 1990;22:1468.PubMedGoogle Scholar
  4. 5.
    Glanville A, Rowland M, Macdonald P, Keogh A, Bryant D, Spratt P. Native lung pathology after single lung transplantation. J Heart Lung Transplant. 1994;13(Suppl.):S32.Google Scholar
  5. 6.
    Colquhoun IW, Gascoigne AD, Gould K, Corris PA, Dark JH. Native pulmonary sepsis after single-lung transplantation. Transplantation. 1991;52:931.PubMedCrossRefGoogle Scholar
  6. 7.
    Horvath J, Dummer S, Loyd J, Walker B, Merrill WH, Frist WH. Infection in the transplanted and native lung after single lung transplantation. Chest. 1993;104:681.PubMedGoogle Scholar
  7. 8.
    Patterson GA, Maurer JR, Williams TJ, Cardoso PG, Scavuzzo M, Todd TR, Toronto Lung Transplant Group. Comparison of outcomes of double and single lung transplantation for obstructive lung disease. J Thorac Cardiovasc Surg. 1991;101:623.PubMedGoogle Scholar
  8. 9.
    McGregor CGA, Daly RC, Peters SG et al. Evolving strategies in lung transplantation for emphysema. Ann Thorac Surg. 1994;57:1513.PubMedCrossRefGoogle Scholar
  9. 10.
    Zannini P, Baisi A, Melloni G et al. Single lung transplantation for emphysema: lessons learned on the field. Int Surg. 1992;77:28.PubMedGoogle Scholar
  10. 11.
    Novick RJ, Menkis AH, Sandler D et al. Contracteral pneumonectomy after singlelung transplantation for emphysema. Ann Thorac Surg. 1991;52:1317.PubMedCrossRefGoogle Scholar
  11. 12.
    Bolman RM III, Shumway SJ, Estrin JA, Hertz MI. Lung and heart-lung transplantation: evolution and new applications. Ann Surg. 1992;214:456.CrossRefGoogle Scholar
  12. 13.
    Howard DK, Iademarco EJ, Trulock EP. The role of cardiopulmonary exercise testing in lung and heart-lung transplantation. Clin Chest Med. 1994;15:405.PubMedGoogle Scholar
  13. 14.
    Patterson GA. Bilateral lung transplant: indications and technique. Sem Thorac Cardiovasc Surg. 1992;4:95.Google Scholar
  14. 15.
    Fremes SE, Patterson GA, Williams WG, Goldman BS, Todd TRT, Maurervc J, Toronto Lung Transplant Group. Single lung transplantation and closure of patent ductus arteriosus for Eisenmenger’s syndrome. J Thorac Cardiovasc Surg. 1990;100:1.PubMedGoogle Scholar
  15. 16.
    McCarthy PM, Rosenkranz ER, White RD et al. Single-lung transplantation with atrial septal defect repair for Eisenmenger’s syndrome. Ann Thorac Surg. 1991;52:300.PubMedCrossRefGoogle Scholar
  16. 17.
    O’Kelly SW, Hayden-Smith J. Eisenmenger’s syndrome: surgical perspectives and anaesthetic implications (Review). Br J Hosp Med. 1994;51:150.PubMedGoogle Scholar
  17. 18.
    Kreitmann B. Metras D, Badier M. Unilateral lung transplantation for Eisenmenger’s syndrome. J Thorac Cardiovasc Surg. 1992;104:529.PubMedGoogle Scholar
  18. 19.
    Bando K, Armitage JM, Paradis IL et al. Indications for and results of single, bilateral, and heart-lung transplantation for pulmonary hypertension. J Thorac Cardiovasc Surg. 1994;108:1056.PubMedGoogle Scholar
  19. 20.
    Lupinetti FM, Bolling SF. Bove EL et al. Selective lung or heart-lung transplantation for pulmonary hypertension associated with congenital cardiac anomalies. Ann Thorac Surg. 1994;57:1545.PubMedCrossRefGoogle Scholar
  20. 21.
    King MB, Kshettry V, Bolman RM, Gross CR, Savik K, Hertz MI. Outcomes after lung transplantation based on pre-transplant diagnosis. Am J Respir Crit Care Med. 1995;151:A88.Google Scholar
  21. 22.
    Frist WH, Loyd JE, Merrill WH et al. Single lung transplantation: a temporal look at rejection, infection, and survival. Am Surg.. 1994;60:94.PubMedGoogle Scholar
  22. 23.
    Pasque MK, Kaiser LR, Dresler CM, Trulock H, Triantafillou AM, Cooper JD. Single lung transplantation for pulmonary hypertension. J Thorac Cardiovasc Surg. 1992;103:475.PubMedGoogle Scholar
  23. 24.
    Dittrich HC, Nicod PH, Chow LC, Chappuis FP, Moser KM, Peterson KL. Early changes of right heart geometry after pulmonary thromboendarterectomy. J Am Coll Cardiol. 1988;11:937.PubMedCrossRefGoogle Scholar
  24. 25.
    Maurer JR, Winton TL, Patterson GA, Williams TR. Single-lung transplantation for pulmonary vascular disease. Transplant Proc. 1991;23:1211.PubMedGoogle Scholar
  25. 26.
    Starnes VA, Lewiston NJ, Luikart H. Theodore J, Stinson EB, Shumway NE. Current trends in lung transplantation. Lobar transplantation and expanded use of single lungs. J Thorac Cardiovasc Surg. 1992;104:1065.Google Scholar
  26. 27.
    Starnes VA, Barr ML, Cohen RG. Lobar transplantation: indications, technique, and outcome. J Thorac Cardiovasc Surg. 1994;108:403.PubMedGoogle Scholar
  27. 28.
    Ginsberg RJ, Hill LD, Eagan RT. Modern thirty-day operative mortality for surgical resection in lung cancer. J Thorac Cardiovasc Surg. 1983;86:654.PubMedGoogle Scholar
  28. 29.
    Cohen RG, Barr ML, Schenkel FA, DeMeesler TR, Wells WJ, Starnes VA. Livingrelated donor lobectomy for bilateral lobar transplantation in patients with cystic fibrosis. Ann Thorac Surg. 1994;57:1423.PubMedCrossRefGoogle Scholar
  29. 30.
    Shaw LR, Miller JD, Slutsky AS et al. Ethics of lung transplantation with live donors. Lancet. 1991;338:678.PubMedCrossRefGoogle Scholar
  30. 31.
    Snell GI, Winton TL, Kesten S, Maurer JR. Lung transplantation in patients over the age of 50. Transplantation. 1993;55:562.PubMedCrossRefGoogle Scholar
  31. 32.
    Shane E, Schulman L, McGregor C et al. Osteoporosis in patients awaiting lung transplantation. Am Rev Respir Crit Care Med. 1995;151:A91.Google Scholar
  32. 33.
    Aris R, Neuringer I, Weiner M, Cairns E, Paradowski L, Ontjes D. Severe osteoporosis in patients undergoing lung transplantation. Am Rev Respir Crit Care Med. 1995;151:A91.Google Scholar
  33. 34.
    Levine SM, Anzueto A, Peters JI, Calhoon JH, Jenkinson SG, Bryan CL. Single lung transplantation in patients with systemic disease. Chest. 1994;105:837.PubMedGoogle Scholar
  34. 35.
    Marshall SE, Kramer MR, Lewiston NJ, Starnes VA, Theodore J. Selection and evaluation of recipients for heart-lung and lung transplantation. Chest. 1990;98:1488.PubMedGoogle Scholar
  35. 36.
    Snell GI, de Hoyos A, Winton TL, Krajden M, Maurer JR. Pseudomonas cepacia in lung transplant recipients with cystic fibrosis. Chest 1993;103:466.PubMedGoogle Scholar
  36. 37.
    Egan TM, Detterbeck FC, Mill MR et al. Improved results of lung transplantation for patients with cystic fibrosis. J Thorac Cardiovasc Surg. 1995;109:224.PubMedCrossRefGoogle Scholar
  37. 38.
    Miller JD, deHoyos A, Patterson GA. An evaluation of the role of omentopexy and of early perioperative corticosteroid administration in clinical lung transplantation. J Thorac Cardivoasc Surg. 1993;105:247.Google Scholar
  38. 39.
    Dusmet M. Winton TL, Kesten S, Maurer J. Previous intrapleural procedures do not adversely affect lung transplantation. J Heart Lung Transplant 1995;14:A164.Google Scholar
  39. 40.
    Low DE, Trulock EP, Kaiser LR. Lung transplantation of ventilator-dependent patients. Chest. 1992;101:8.PubMedGoogle Scholar
  40. 41.
    End A, Grimm M, Mares P et al. Successful lung transplantation in a long-term ventilator-dependent patient. Ann Thorac Surg. 1993;56:562.PubMedCrossRefGoogle Scholar
  41. 42.
    Massard G, Shennib H, Metras D et al. Double-lung transplantation in mechanically ventilated patients with cystic fibrosis. Ann Thorac Surg. 1993;55:1087.PubMedCrossRefGoogle Scholar
  42. 43.
    Flume PA, Egan TM, Westerman JH et al. Lung transplantation for mechanically ventilated patients. J Heart Lung Transplant. 1994;13:15.PubMedGoogle Scholar
  43. 44.
    Madill J, Maurer JR, de Hoyos A. A comparison of preoperativc and postoperative nutritional states of lung transplant recipients. Transplantation. 1993;56:347.PubMedCrossRefGoogle Scholar
  44. 45.
    Dennis C, Caine N, Sharples L et al. Heart-lung transplantation for end-stage respiratory disease in patients with cystic fibrosis at Papworth Hospital. J Heart Lung Transplant. 1993;12:893.PubMedGoogle Scholar
  45. 46.
    Kelly P, Bart C, Craven J. Lung transplantation. In: Craven J, Rodin GM, editors. Psychiatric aspects of organ transplantation. Oxford: Oxford Medical Publishers; 1992:205.Google Scholar
  46. 47.
    Kerem E, Reisman J, Corey M, Canny GJ, Levison H. Prediction of mortality in patients with cystic fibrosis. N Engl J. Med. 1992;326:1187.PubMedCrossRefGoogle Scholar
  47. 48.
    Sharples L, Hathaway T, Dennis C, Caine N, Higenbottam T, Wallwork J. Prognosis of patients with cystic fibrosis awaiting heart and lung transplantation. J Heart Lung Transplant. 1993;12:669.PubMedGoogle Scholar
  48. 49.
    Shennib H. Noirclerc M, Ernst P et al. Cystic Fibrosis Transplant Study Group Double-lung transplant for cystic fibrosis. Ann Thorac Surg. 1992;54:27.PubMedCrossRefGoogle Scholar
  49. 50.
    Slarnes V, Lewiston N, Theodore J et al. Cystic fibrosis: target population for lung transplantation in North America in the 1990s. J Thorac Cardiovasc Surg. 1992;103:1008.Google Scholar
  50. 51.
    Hayden AM, Robert RC, Kriett JM, Smith CM, Nicholson K, Jamieson SW. Primary diagnosis predicts prognosis of lung transplant candidates. Transplantation. 1993;55:1048.PubMedCrossRefGoogle Scholar
  51. 52.
    WHO. Therapeutic approaches to cystic fibrosis: memorandum from a joint WHO/ICF(M)A Meeting. Bull World Health Org. 1994;72:341.Google Scholar
  52. 53.
    Egan TW, Trulock EP, Boychuk J, Ochoa L, Cooper JD, Washington University Lung Transplantation Group. Analysis of referrals for lung transplantation. Chest. 1991;99:867.PubMedGoogle Scholar
  53. 54.
    Centers for Disease Control and Prevention/National Center for Health Statistics, U.S. Department of Health and Human Services. Monthly Vital Statistics Report. Advance Report of Final Mortality Statistics; 1991(1993):42(2).Google Scholar
  54. 55.
    Antonisen N. Prognosis in chronic obstructive pulmonary disease: results from rnulticenter clinical trials. Am Rev Respir Dis. 1989;140:S95.Google Scholar
  55. 56.
    Antonisen NR, Wright EC, Hodgkin JE. Prognosis in chronic obstructive pulmonary disease. Am Rev Respir Dis. 1986;133:14.Google Scholar
  56. 57.
    Sharples L, Belcher C, Dennis C, Higenbottam T, Wallwork J. Who waits longest for heart and lung transplantation? J Heart Lung Transplant. 1994;13:282.PubMedGoogle Scholar
  57. 58.
    Carrington CB, Gaensler F-A, Coutu RE. Natural history and treated course of usual and desquamative interstitial pneumonia. N Engl J Med. 1978;298:801.PubMedCrossRefGoogle Scholar
  58. 59.
    Jackson LK, Idiopathic pulmonary fibrosis. Clin Chest Med. 1982;3:579.PubMedGoogle Scholar
  59. 60.
    Johnson MA, Kwan S, Snell NJ, Nunn AJ, Darbyshire JH, Turner-Warwick MA. Randomised controlled trial comparing prednisolone alone with cyclophosphamide and low dose prednisolone in combination in cryptogenic fibrosing alveolitis. Thorax. 1989;44:280.PubMedCrossRefGoogle Scholar
  60. 61.
    Venuta F, Rendina EA, Ciriaco P et al. Efficacy of cyclosporin to reduce steroids in patients with idiopathic pulmonary fibrosis before lung transplantation. J Heart Lung Transplant. 1993;12:909.PubMedGoogle Scholar
  61. 62.
    D’Alonzo GE, Barst RJ, Ayres SM et al. Survival in patients with primary pulmonary hypertension: Results from a national prospective registry. Ann Intern Med. 1991;115:343.PubMedGoogle Scholar
  62. 63.
    Kramer MR, Marshall SE, Tiroke A, Lewiston NJ, Starnes VA, Theodore J. Clinical significance of hyperbilirubinemia in patients with pulmonary hypertension undergoing heart-lung transplantation. J Heart Lung Transplant. 1991;10:317.PubMedGoogle Scholar
  63. 64.
    Nootens M, Freels S, Kaufmann E, Levy PS, Rich S. Timing of single lung transplantation for primary pulmonary hypertension. J Heart Lung Transplant. 1994;13:276.PubMedGoogle Scholar
  64. 65.
    Snell GI, Salamonse RF, Bergin P, Esmore DS, Khan S, Williams TJ. Inhaled nitric oxide used as a bridge to heart-lung transplantation in a patient with end-stage pulmonary hypertension. Am J Respir Crit Care Med. 1995;151:1263.PubMedGoogle Scholar
  65. 66.
    Gorcsan J III, Edwards TD, Ziady GM, Katz WE, Griffith BP. Transesophageal echocardiography to evaluate patients with severe pulmonary hypertension for lung transplantation. Ann Thorac Surg. 1995;59:717.PubMedCrossRefGoogle Scholar
  66. 67.
    Leibowitz DW, Caputo AL, Shapiro GC et al. Coronary angiography in smokers undergoing evaluation for lung transplantation: is routine use justified? J Heart Lung Transplant. 1994;13:701.PubMedGoogle Scholar
  67. 68.
    Craven JL, Bright J, Dear CL. Psychiatric, psychosocial, and rehabilitative aspects of lung transplantation. Clin Chest Med 1990;11:247.PubMedGoogle Scholar
  68. 69.
    Biggar DG, Malen JF, Trulock EP, Cooper JD. Pulmonary rehabilitation before and after lung transplantation. In: Casaburi R, Petty TL, editors. Principles and practice of pulmonary rehabilitation. Philadelphia PA: W.B. Saunders; 1993:459.Google Scholar
  69. 70.
    Novick RJ, Andreassian B, Schafers H-J et al. Pulmonary retransplantation for obliterative bronchiolitis. J Thorac Cardiovasc Surg. 1994;107:755.PubMedGoogle Scholar
  70. 71.
    Novick RJ, Kaye MP, Patterson GA et al. Redo lung transplantation: a North American-European experience. J Heart Lung Transplant. 1993;12:5.PubMedGoogle Scholar
  71. 72.
    Armitage JM, Kurland G, Michaels M, Cipriani LA, Griffith BP, Fricker FJ. Critical issues in pediatric lung transplantation. J Thorac Cardiovasc Surg. 1995;109:60.PubMedCrossRefGoogle Scholar
  72. 73.
    Maynard LC. Pediatric heart-lung transplantation for cystic fibrosis. Heart Lung. 1994;23:279.PubMedGoogle Scholar
  73. 74.
    Armitage JM, Fricker FJ, Kurland G, Michaels M, Griffith BP. Pediatric lung transplantation: expanding indications, 1985–1993. J Heart Lung Transplant. 1993;12:S246.PubMedGoogle Scholar
  74. 75.
    Steinberger J, Haines HC, Shumway SJ, Bolman RM III, Rocchini AP, Braunlin EA. Outcome after referral for pediatric transplantation. J Heart Lung Transplant. 1993;12:766.PubMedGoogle Scholar
  75. 76.
    Nine JS, Yousem SA, Paradis IL, Keenan R. Griffith BP. Lymphangioleiomyomatosis: recurrence after lung transplantation. J Heart Lung Transplant. 1994;13:714.PubMedGoogle Scholar
  76. 77.
    Martinez FJ, Orens JB, Deeb M, Brunsting LA, Flint A, Lynch JP III. Recurrence of sarcoidosis following bilateral allogeneic lung transplantation. Chest. 1994;106:1597.PubMedGoogle Scholar
  77. 78.
    Johnson BA, Duncan SR, Ohori NP et al. Recurrence of sarcoidosis in pulmonary allograft recipients. Am Rev Respir Dis. 1993;148:1373.PubMedGoogle Scholar
  78. 79.
    Heatly T, Sekela M, Berger R. Single lung transplantation involving a donor with documented pulmonary sarcoidosis. J Heart Lung Transplant. 1994;13:720.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • J. R. Maurer

There are no affiliations available

Personalised recommendations