Pathology of Cardiac Allograft Vasculopathy (Chronic Rejection)

  • A. G. Rose


In the quarter-century since the first human heart transplant was performed by Barnard in 1967[1], this operation has become a well-established therapy for treating irremediable cardiac failure. Survival rates have progressively improved[2],[3] (Chapters 43 and 44) and the 1-year survival following the operation is 80% or greater. Over 20 000 heart transplants have been performed worldwide. In patients who die in the first few months after cardiac transplantation when immunosuppression is maximal, infection is a major cause of death[4],[5] (Chapter 32). Rejection is also an important factor which, if not primarily responsible for the patient’s death, contributes significantly to it, even when overwhelming infection is present[6],[7]. The clinical pattern of acute cardiac rejection, and the role of endomyocardial biopsy in its diagnosis, have been outlined in Chapter 30.


Acute Rejection Cardiac Transplantation Chronic Rejection Endomyocardial Biopsy Cardiac Allograft 
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© Kluwer Academic Publishers 1996

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  • A. G. Rose

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