Experimental Development and Early Clinical Experience

  • D. K. C. Cooper


Clinical heart transplantation was made possible by the considerable experimental work carried out earlier this century, which embraced mainly the technical, physiological and immunological aspects of the procedure. This chapter endeavours to review briefly the evolution and results of experimental surgical techniques utilized by cardiac transplant research workers; a comprehensive review appears elsewhere[1].


Acute Rejection Cardiac Allograft Orthotopic Transplantation Profound Hypothermia Thoracic Organ 
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  1. 1.
    Cooper DKC. Experimental development of cardiac transplantation. Br Med J. 1968;4:174.PubMedCrossRefGoogle Scholar
  2. 2.
    Carrel A, Guthrie CC. The transplantation of veins and organs. Am Med (Philadelphia). 1905;10:1101.Google Scholar
  3. 3.
    Carrel A. The surgery of blood vessels. Bull Johns Hopkins Hosp. 1907;18:18.Google Scholar
  4. 4.
    Mann FC, Priestley JT, Markowitz J, Yater WM. Transplantation of the intact mammalian heart. Arch Surg. 1933;26:219.Google Scholar
  5. 5.
    Abbott CP, Lindsey ES, Creech O Jr, De Witt CW. A technique for heart transplantation in the rat. Arch Surg. 1964;89:645.PubMedGoogle Scholar
  6. 6.
    Abbott CP, De Witt CW, Creech O Jr. The transplanted rat heart; histologic and electrocardiographic changes. Transplantation. 1965;3:432.PubMedCrossRefGoogle Scholar
  7. 7.
    Demikhov VP. Experimental transplantation of vital organs. Authorized translation from the Russian by Haigh B. New York: Consultants Bureau; 1962.Google Scholar
  8. 8.
    Reemtsma K. The heart as a test organ in transplantation studies. Ann NY Acad Sci. 1964;120:778.PubMedCrossRefGoogle Scholar
  9. 9.
    Barnard CN, Losman JG. Left ventricular bypass. S Afr Med J. 1975;49:303.PubMedGoogle Scholar
  10. 10.
    Losman JG, Barnard CN. Hemodynamic evaluation of left ventricular bypass with a homologous cardiac graft. J Thorac Cardiovasc Surg. 1977;74:695.PubMedGoogle Scholar
  11. 11.
    Sen PK, Parulkar GB, Panday SR, Kinare SG. Homologous canine heart transplantation; a preliminary report of 100 experiments. Indian J Med Res. 1965;53:674.PubMedGoogle Scholar
  12. 12.
    Neptune WB, Cookson BA, Bailey CP, Appier R, Rajkowski F. Complete homologous heart transplantation. Arch Surg. 1953;66:174.Google Scholar
  13. 13.
    Webb WR, Howard HS. Cardiopulmonary transplantation. Surg Forum. 1957;8:313.PubMedGoogle Scholar
  14. 14.
    Webb WR, Howard HS, Neely WA. Practical methods of homologous cardiac transplantation. J Thorac Surg. 1959;37:361.PubMedGoogle Scholar
  15. 15.
    Goldberg M, Berman EF, Akman LC. Homologous transplantation of the canine heart. J Int Coll Surg. 1958;30:575.Google Scholar
  16. 16.
    Berman EF, Goldberg M, Akman L. Experimental replacement of the heart in the dog. Transplant Bull. 1958;5:10.PubMedCrossRefGoogle Scholar
  17. 17.
    Cass MH, Brock R. Heart excision and replacement. Guy’s Hosp Rep. 1959;108:285.Google Scholar
  18. 18.
    Lower RR, Shumway NE. Studies on orthotopic homotransplantation of the canine heart. Surg Forum. 1960;11:18.PubMedGoogle Scholar
  19. 19.
    Barnard CN. What we have learned about heart transplants. J Thorac Cardiovasc Surg. 1968;56:457.PubMedGoogle Scholar
  20. 20.
    Lower RR, Stofer RC, Hurley EJ, Shumway NE. Complete homograft replacement of the heart and both lungs. Surgery. 1961;50:842.PubMedGoogle Scholar
  21. 21.
    Hurley EJ, Dong E Jr, Stofer RC, Shumway NE. Isotopic replacement of the totally excised canine heart. J Surg Res. 1962;2:90.PubMedCrossRefGoogle Scholar
  22. 22.
    Dong E Jr, Hurley EJ, Lower RR, Shumway NE. Performance of the heart two years after autotransplantation. Surgery. 1964;56:270.PubMedGoogle Scholar
  23. 23.
    Lower RR, Stofer RC, Shumway NE. Homovital transplantation of the heart. J Thorac Cardiovasc Surg. 1961;41:196.PubMedGoogle Scholar
  24. 24.
    Lower RR, Stofer RC, Hurley EJ, Dong E Jr, Cohn RB, Shumway NE. Successful homotransplantation of the canine heart after anoxic preservation for seven hours. Am J Surg. 1962;104:302.PubMedCrossRefGoogle Scholar
  25. 25.
    Lower RR, Dong E Jr, Shumway NE. Long-term survival of cardiac homografts. Surgery. 1965;58:110.PubMedGoogle Scholar
  26. 26.
    Shumway NE, Lower RR. Special problems in transplantation of the heart. Ann NY Acad Sci. 1964;120:773.PubMedCrossRefGoogle Scholar
  27. 27.
    Lower RR, Dong E Jr, Glazener FS. Electrocardiograms of dogs with heart homografts. Circulation. 1964;33:455.Google Scholar
  28. 28.
    Angell WW, Dong E Jr, Shumway NE. Four-day storage of the canine cadaver heart. Surg Forum. 1967;18:223.Google Scholar
  29. 29.
    Willman VL, Cooper T, Cian LG, Hanlon CR. Autotransplantation of the canine heart. Surg Gynecol Obstet. 1962;115:299.PubMedGoogle Scholar
  30. 30.
    Willman VL, Cooper T, Kaiser GC, Hanlon CR. Cardiovascular response after cardiac autotransplant in primate. Arch Surg. 1965;91:805.PubMedGoogle Scholar
  31. 31.
    Kondo Y, Giadel F, Kantrowitz A. Heart homotransplantation in puppies: long survival without immunosuppressive therapy. Circulation. 1965;31(Suppl. l):181.PubMedGoogle Scholar
  32. 32.
    Reemtsma K. Williamson WR Jr, Iglesias F, Pena E, Sayegh SF, Creech O Jr. Studies in homologous canine heart transplantation; prolongation of survival with a folic acid antagonist. Surgery. 1962;52:127.PubMedGoogle Scholar
  33. 33.
    Blumenstock DA, Hechtman HB, Jaretzki A, Hosbein JD, Zingg W, Powers JH. Prolonged survival of orthotopic homotransplants of the heart in animals treated with methotrexate. J Thorac Cardiovasc Surg. 1963;46:616.PubMedGoogle Scholar
  34. 34.
    Hardy JD, Webb WR, Dalton ML Jr. Walker GR Jr. Lung homotransplantation in man; report of the initial case. J Am Med Assoc. 1963;186:1065.Google Scholar
  35. 35.
    Hardy JD, Chavez CM, Kurrus FE et al. Heart transplantation in man; developmental studies and report of a case. J Am Med Assoc. 1964;188:1132.Google Scholar
  36. 36.
    Reemtsma K, McCracken BH, Schlegel JU, Pearl MA, De Witt CW, Creech O Jr. Reversal of early graft rejection after renal heterotransplantation in man. J Am Med Assoc. 1964;187:691.Google Scholar
  37. 37.
    Barnard CN. The operation. A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. S Afr Med J. 1967;41:1271.PubMedGoogle Scholar
  38. 38.
    Thompson JG. Heart transplantation in man-necropsy findings. Br Med J. 1968;2:511.Google Scholar
  39. 39.
    Thompson JG. Atheroma in a transplanted heart. Lancet. 1969;2:1297.PubMedCrossRefGoogle Scholar
  40. 40.
    Baumgartner WA, Reitz BA, Oyer PE, Stinson EB, Shumway NE. Cardiac homotransplantation. Curr Probl Surg. 1979;61:1.CrossRefGoogle Scholar
  41. 41.
    Lower RR, Szentpetery S, Thomas FT, Kemp VE. Clinical observations on cardiac transplantation. Transplant Proc. 1976;8:9.PubMedGoogle Scholar
  42. 42.
    Cabrol C, Gandjbakhch I, Guiraudon G et al. Cardiac transplantation; our experience at La Pitié Hospital in Paris. Heart Transplant. 1982;1:116.Google Scholar
  43. 43.
    Barnard CN, Barnard MS, Cooper DKC et al. The present status of heterotopic cardiac transplantation. J Thorac Cardiovasc Surg. 1981;81:433.PubMedGoogle Scholar
  44. 44.
    Caves PK, Stinson EB, Graham AF, Billingham ME, Grehl TM, Shumway NE. Percutaneous transvenous endomyocardial biopsy. J Am Med Assoc. 1973;225:288.CrossRefGoogle Scholar
  45. 45.
    Caves PK, Billingham ME, Stinson EB, Shumway NE. Serial transvenous biopsy of the transplanted human heart-improved management of acute rejection episodes. Lancet. 1974;1:821.PubMedCrossRefGoogle Scholar
  46. 46.
    Borel JF, Feurer C, Gubler HU, Stahelin H. Biological effects of cyclosporin-A: a new antilymphocytic agent. Agents Actions. 1976;6:468.PubMedCrossRefGoogle Scholar
  47. 47.
    Calne RY, White DJ, Rolles K, Smith DP, Herbertson BM. Prolonged survival of pig orthotopic heart grafts treated with cyclosporin-A. Lancet. 1978;1:1183.PubMedCrossRefGoogle Scholar
  48. 48.
    Reitz BA, Bieber CP, Raney AA et al. Orthotopic heart and combined heart and lung transplantation with cyclosporin-A immune suppression. Transplant Proc. 1981;13:393.PubMedGoogle Scholar
  49. 49.
    Oyer PE, Stinson EB, Jamieson SW et al. One year experience with cyclosporin A in clinical heart transplantation. Heart Transplant. 1982;1:285.Google Scholar
  50. 50.
    Calne RY. Inhibition of the rejection of renal homografts in dogs by purine analogues. Transplant Bull. 1961;28:65.PubMedGoogle Scholar
  51. 51.
    Goodwin WE, Kaufman JJ, Mims MM et al. Human renal transplantation. I. Clinical experiences with six cases of renal homotransplantation. J Urol 1963;89:13.PubMedGoogle Scholar
  52. 52.
    Bristow MR, Gilbert EM, Renlund DG, DeWitt CW, Burton NA, O’Connell JB. Use of OKT3 monoclonal antibody in heart transplantation: review of the initial experience. J Heart Transplant. 1988;7:1.Google Scholar

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© Kluwer Academic Publishers 1996

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  • D. K. C. Cooper

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