Tacrolimus (FK506) in Thoracic Organ Transplantation
Tacrolimus (FK506) was discovered as the result of a systematic screening program to look for an improved immunosuppressant. In the mid-1980s Goto and associates from the Exploratory Research Laboratories of Fujisawa Pharmaceutical Co. Ltd, Japan, discovered a macrolide compound that had potent immunosuppressive properties–. This compound, then named FK506, was extracted from the fermentation broth of the soil fungus Streptomyces tsukubaensis. Further preclinical studies on the immunosuppressive properties of this compound on organ transplantation were carved out intensively at Chiba University, Japan–, Cambridge University, UK–, and the University of Pittsburgh, USA–. The initial results of FK506 as an effective immunosuppressant in organ transplantation were presented at the first International Symposium on FK506 in June 1987, in Gëteborg, Sweden, and were subsequently published in Transplantation Proceedings (Vol. 19, Suppl. 6, 1987).
KeywordsAcute Rejection Transplant Proc Liver Transplant Recipient Obliterative Bronchiolitis Tacrolimus Group
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