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Tacrolimus (FK506) in Thoracic Organ Transplantation

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The Transplantation and Replacement of Thoracic Organs

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Abstract

Tacrolimus (FK506) was discovered as the result of a systematic screening program to look for an improved immunosuppressant. In the mid-1980s Goto and associates from the Exploratory Research Laboratories of Fujisawa Pharmaceutical Co. Ltd, Japan, discovered a macrolide compound that had potent immunosuppressive properties[1]–[3]. This compound, then named FK506, was extracted from the fermentation broth of the soil fungus Streptomyces tsukubaensis. Further preclinical studies on the immunosuppressive properties of this compound on organ transplantation were carved out intensively at Chiba University, Japan[4]–[9], Cambridge University, UK[10]–[12], and the University of Pittsburgh, USA[13]–[18]. The initial results of FK506 as an effective immunosuppressant in organ transplantation were presented at the first International Symposium on FK506 in June 1987, in Gëteborg, Sweden, and were subsequently published in Transplantation Proceedings (Vol. 19, Suppl. 6, 1987).

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Authors
  1. J. S. Gammie
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  2. S. M. Pham
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Editor information

Editors and Affiliations

  1. Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston

    David K. C. Cooper MA, PhD, MD, MS, FRCS, FACC, FACS

  2. Oklahoma Medical Research Foundation, Oklahoma City, USA

    David K. C. Cooper MA, PhD, MD, MS, FRCS, FACC, FACS

  3. St Louis University Health Sciences Center, St Louis, USA

    Leslie W. Miller MD, FACC

  4. Washington University School of Medicine, St Louis, USA

    G. Alexander Patterson MD, FRCS(C), FACS

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© 1996 Kluwer Academic Publishers

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Gammie, J.S., Pham, S.M. (1996). Tacrolimus (FK506) in Thoracic Organ Transplantation. In: Cooper, D.K.C., Miller, L.W., Patterson, G.A. (eds) The Transplantation and Replacement of Thoracic Organs. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-34287-0_10

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  • DOI: https://doi.org/10.1007/978-0-585-34287-0_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-8898-2

  • Online ISBN: 978-0-585-34287-0

  • eBook Packages: Springer Book Archive

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