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Evaluation of Endocrine Activities and Hormonal Metabolic Control in Training and Overtraining

  • Atko Viru
  • Mehis Viru

Abstract

An essential task of hormones in metabolic control is to interference into cellular autoregulation and to ensure an extensive mobilization of resources of the body. Otherwise the actualization of potential capacities of the body is impossible. Accordingly, the exercise performance depends on influence of hormones on metabolic processes. Therefore, the magnitudes of hormonal responses in exercises, including competition performance, as well as their interrelations, allow us to understand the actual mobilization of various metabolic resources. However, in monitoring of training the significance of hormonal studies is not limited only by this approach. The determination of hormones can provide information on the adaptation to certain levels of exercise intensity and duration, as well as on disorders of adaptation, including exhaustion of the organism’s adaptivity and overtraining phenomena. Hormonal responses can be used for assessment of the trainable effect of exercise session and for control of the recovery period. In order to get actually information and to avoid misunderstandings and wrong depiction, several cautions and limitations must be taken into the consideration.

Keywords

Growth Hormone Testosterone Level Hormonal Response Hormone Concentration Salivary Cortisol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    American College of Sports Medicine (1994) Guidelines for exercise testing and presriptcion. 4th edit. Lea & Febiger PhiladelphiaGoogle Scholar
  2. 2.
    Adamson L, Hunter WM, Ogurremi OO, Oswald I, Percy-Robb IW (1974) Growth hormone increase during sleep after daytime exercise. J Endocrinol 62:473–478PubMedGoogle Scholar
  3. 3.
    Adlercreutz H, Härkönen M, Kuoppasalmi K, Näveri H, Huhtaniemi TM, Tikkanen H, Remes K, Dessypris A, Karvonen J (1986) Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise. Int J Sports Med, 7(Suppl. 1):27–28PubMedGoogle Scholar
  4. 4.
    Balon TW, Zorzano A, Treadway JL, Goodman MN, Ruderman NB (1990) Effects of insulin on protein synthesis and degradation in skeletal muscle after exercise. Am J Physiol 258:E92–E98PubMedGoogle Scholar
  5. 5.
    Banfi G, Marinelli M, Roi GS, Agape B (1993) Usefulness of free testosterone/cortisol ratio during a season of elite speed skating athletes. Int J Sports Med 14:373–379PubMedGoogle Scholar
  6. 6.
    Barron GL, Noakes TD, Levy W, Smith C, Millar RP (1985) Hypothalamic dysfunction in overtrained athletes. J Clin Endocrin Metab 60:803–806Google Scholar
  7. 7.
    Beyer P, Knuppen S, Zehender R, Witt D, Rieckert H, Brack C, Kruse K, Ball P (1990) Changes in spontaneous growth hormone (GH) secretion in athletes during different training period over one year. Acta Endocrin 22(Suppl. 1):35Google Scholar
  8. 8.
    Bonen A, Belcastro AN (1978) Effect of exercise and training on menstrual cycle hormones. Austr J Sports Med 10:39–43Google Scholar
  9. 9.
    Booth FW, Thomason DB (1991) Molecular and cellular adaptation of muscle in response to exercise:perspectives of various models. Physiol Rev 71:541–585PubMedGoogle Scholar
  10. 10.
    Bosco C, Tihanyi J, Viru A (1996) Relationship between field fitness test and basal serum testosterone and cortisol levels in soccer players. Clin Physiol 16:317–322PubMedGoogle Scholar
  11. 11.
    Brandenberger G, Follenius M, Hietter B, Reinhardt B, Simeoni M (1982) Feedback from meal-related peaks determines diurnal changes in cortisol response to exercise. J Clin Endocrin 54:592–596Google Scholar
  12. 12.
    Busso T, Häkkinen K, Pakarinen A, Carasso C, Lacour JR, Komi PV, Kauhanen H (1990) A systems model of training responses and its relationship to hormonal responses in elite weight-lifters. Eur J Appl Physiol 61:48–54CrossRefGoogle Scholar
  13. 13.
    Cook NJ, Ng A, Read GF, Harris B, Riad-Fahmy D (1987) Salivary cortisol for monitoring adrenal activity during marathon runs. Horm Res 25:18–23PubMedGoogle Scholar
  14. 14.
    Cuneo RC, Salomon F, Wills CM, Sonksen PH (1991) Growth hormone treatment in growth hormone-deficient adults. I Effects on muscle mass and strength. J Appl Physiol 70:688–694PubMedGoogle Scholar
  15. 15.
    Danhaive PA, Rousseau GG (1988) Evidence for sex-dependent anabolic response to androgenic steroids mediated by glucocorticoid receptors in rat. J Steroid Biochem 29:275–281CrossRefGoogle Scholar
  16. 16.
    Dux L, Dux E, Guba F (1982) Further data on the androgenic dependence of the skeletal muscle. Horm Metab Res 14:191–194PubMedGoogle Scholar
  17. 17.
    Fain JN (1979) Inhibition of glucose transport in fat cells and activation of lipolysis by glucocorticoids. In: Baxter JD, Rousseau GG (eds) Glucocorticoid hormone action. Springer-Verlag Berlin, Heidelberg, New York: 547–560Google Scholar
  18. 18.
    Fain JN, Kovacov VP, Scow RO (1965) Effect of growth hormone and dexamethasone on lipolysis and metabolism in isolated fat cells of the rat. J Biol Chem 240:3522–3529PubMedGoogle Scholar
  19. 19.
    Fergusson DB, Price DA, Wallace S (1980) Effects of physiological variables on the concentration of cortisol in human saliva. Adv Physiol Sci 28:301–313Google Scholar
  20. 20.
    Few JD, Imms FJ, Weiner JS (1975) Pituitary-adrenal response to static exercise in man. Clin Sci Mol Med 49:201–206PubMedGoogle Scholar
  21. 21.
    Fry RW, Morton AR, Garcia-Webb P (1992) Biological responses to overload training in endurance sports. Eur J Appl Physiol 64:335–344CrossRefGoogle Scholar
  22. 22.
    Galbo H (1983) Hormonal and metabolic adaptation to exercise. G.Thieme Stuttgart, New YorkGoogle Scholar
  23. 23.
    Guezennec GY, Ferre P, Serrurier B, Merino D, Amonad M, Pesquires PC (1984) Metabolic effects of testosterone during prolonged physical exercise and fasting. Eur J Appl Physiol 52:300–304CrossRefGoogle Scholar
  24. 24.
    Hackney AC, Ness RJ, Schrieber A (1989) Effects of endurance exercise on nocturnal hormone concentrations in males. Chronobiol Intern 6:341–346CrossRefGoogle Scholar
  25. 25.
    Hackney AC, Gulledge T (1994) Thyroid hormone responses during an 8-hour period following aerobic and anaerobic exercise. Physiol Res 43:1–5PubMedGoogle Scholar
  26. 26.
    Häkkinen K, Keskinen KL, Alen M, Komi PV, Kauhanen H (1989) Serum hormone concentrations during prolonged training in elite endurance trained and strength trained athletes. Eur J Appl Physiol 59:233–238CrossRefGoogle Scholar
  27. 27.
    Häkkinen K, Pakarinen A, Alen M, Kauhanen H, Komi PV (1987) Relationships between training volume, physical performance capacity, and serum hormone concentrations during prolonged training in elite weightlifters. Int J Sports Med 8(Suppl. 1):61–65PubMedGoogle Scholar
  28. 28.
    Häkkinen K, Pakarinen A, Kyrölainen H, Chang S, Kim DH, Komi VP (1990) Neuromuscular adaptation and serum hormones in females during prolonged power training. Int J Sports Med 11:91–98PubMedGoogle Scholar
  29. 29.
    Hickson RC, Davis JR (1981) Partial prevention of glucocorticoid-induced muscle atrophy by endurance training. Am J Physiol 241:E226–E232PubMedGoogle Scholar
  30. 30.
    Hooper SL, Mackinnon LT (1995) Monitoring overtraining in athletes. Sports Med 1995;20:321–327PubMedGoogle Scholar
  31. 31.
    Inoue K, Yamasaki S, Fushiki T, Okada Y, Sugimoto E (1994) Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle. Eur J Appl Physiol 69:88–91CrossRefGoogle Scholar
  32. 32.
    Israel S (1976) Zur Problematik der Übertrainings aus internistischer und leistungsphysiologischer Sicht. Med Sport 16:1–12Google Scholar
  33. 33.
    Keiser A, Poortmans J, Bunnik SJ (1980) Influence of physical exercise on sex hormone metabolism. J Appl Physiol 48:765–769Google Scholar
  34. 34.
    Kindermann W (1986) Overtraining-expression of a disturbed autonomic regulation. Dtsch Z Sportmed 37:238–245Google Scholar
  35. 35.
    Kirwan JP, Costill DL, Flynn MG, Mitchell JB, Fink WJ, Neufer PD, Houmard JA (1988) Physiological responses to successive days of intense training in competitive swimmers. Med Sci Sports Exerc 20:235–259Google Scholar
  36. 36.
    Konovalova G, Masso R, Ööpik V, Viru A (1997) Significance of thyroid hormones in post-exercise incorporation of amino acids into muscle fibers in rats: an autoradiographic study. Endocrin Metab 4:25–31Google Scholar
  37. 37.
    Kraemer WJ, Gordon SE, Fleck SJ, Marchitelli LJ, Mello R, Dzialos JE, Friedl K, Harman E, Maresh C, Fry AC (1991) Endogeneous anabolic hormonal and growth factor response to heavy resistance exercise in males and females. Int J Sports Med 12:228–235PubMedGoogle Scholar
  38. 38.
    Kreuz L, Rose R, Jennings J (1972) Suppression of plasma testosterone levels and psychological stress. Arch Gen Psychiatry 26:479–482PubMedGoogle Scholar
  39. 39.
    Kuipers H, Keizer HA (1988) Overtraining in elite athletes. Sports Med 6:79–92PubMedGoogle Scholar
  40. 40.
    Lehmann M, Baumgarte P, Wiesenack C, Seidel A, Bauman H, Fischer S, Spöri U, Gendrish G, Kaminski R, Keul J (1992) Training-overtraining:influence of a defined increase in training volume vs. training intensity on performance, catecholamines and some metabolic parameters in experienced middle-and long-distance runners. Eur J Appl Physiol 64:169–177CrossRefGoogle Scholar
  41. 41.
    Lehmann M, Dickhuth HH, Gendrisch G, Lazar W, Thunk M, Kaminski R, Aramendi JF, Peterke E, Wieland W, Keul J (1991) Training-overtraining experimental study with experienced middle and long distance runners. Int J Sports Med 12:444–452PubMedGoogle Scholar
  42. 42.
    Lehmann M, Foster C, Keul J (1993) Overtraining in endurance athletes. Med Sci Sports Exerc 25:854–862PubMedCrossRefGoogle Scholar
  43. 43.
    Lehmann M, Gastmann U, Petersen KG (1992) Training-overtraining: performance, and hormone levels, after a defined increase in training volume versus intensity in experienced middle-and long-distance runners. Brit J Sports Med 26:233–242CrossRefGoogle Scholar
  44. 44.
    Lehmann MJ, Lormes W, Opitz-Gress A, Steinacker JM, Netzer N, Foster C, Gastmann K (1997) Training and overtraining: an overview and experimental results in endurance sports. J Sports Med Phys Fitness 1997;37:7–17PubMedGoogle Scholar
  45. 45.
    Lehmann M, Schnee W, Scheu R, Stockhausen W, Bachl N (1992) Decreased nocturnal catecholamine excretion: parameter for an overtraining syndrome in athletes? Int J Sports Med 13:236–242PubMedGoogle Scholar
  46. 46.
    Mayer M, Rosen F (1977) Interaction of glucocorticoids and androgens with skeletal muscle. Metabolism 26:937–962PubMedCrossRefGoogle Scholar
  47. 47.
    Ministry of Fitness and Amateur Sport (1986) Canadian standardized test of fitness operations manual. 3rd edit. Canada: Minister of Supply and ServicesGoogle Scholar
  48. 48.
    Newsholme EA, Parry-Billing M, McAndrew M, Budgett R (1991) Biochemical mechanism to explain some characteristics of overtraining. In: Brouns F (ed) Medical Sports Science, vol.32, Advance in Nutrition and Top Sport. Karger Basel: 79–93Google Scholar
  49. 49.
    Pequignot JM, Peyrin L, Favier R, Flandrois R (1979) Adrenergic response to intense muscular work in sedentary man in relation to emotivity and physical training. Eur J Appl Physiol 40:117–135CrossRefGoogle Scholar
  50. 50.
    Port K (1991) Serum and saliva cortisol responses and blood lactate accumulation during incremental exercise testing. Int J Sports Med 12:490–494PubMedGoogle Scholar
  51. 51.
    Pruett EDR (1985) Insulin and exercise in non-diabetic and diabetic man. In: Fortherby K, Pal SB (eds) Exercise Endocrinology. W.de Gruyter Berlin, New York: 1–23Google Scholar
  52. 52.
    Rowbotton DG, Keast D, Morton AR (1996) The emergency role of glutamine as an indicator of exercise stress and overtraining. Sports Med 21:80–97Google Scholar
  53. 53.
    Seene T, Viru A (1982) The catabolic effect of glucocorticoid on different types of skeletal muscle fibers and its dependence upon muscle activity and interaction with anabolic steroids. J Steroid Biochem 16:349–352PubMedCrossRefGoogle Scholar
  54. 54.
    Sejersted OM, Vollestand NK, Melbo JI (1986) Muscle fluid and electrolyte balance during and following exercise. Acta Physiol Scand 128(Suppl 556):119–127Google Scholar
  55. 55.
    Smals AGH, Kloppenborg PWC, Benraad TJ (1976) Circannual cycle in plasma testosterone levels in man. J Clin Endocrin Metab 42:979–982CrossRefGoogle Scholar
  56. 56.
    Snegovskaya V, Viru A (1993) Elevation of cortisol and somatotropin levels in the course of further improvement of performance capacity in trained rowers. Int J Sports Med 14:202–206PubMedGoogle Scholar
  57. 57.
    Snegovskaya V, Viru A (1992) Growth hormone, cortisol and progesterone levels in rowers during a period of high intensity rowing. Biol Sport 9:93–102Google Scholar
  58. 58.
    Steinacker JM, Laske R, Hetzel WD, Lormes W, Liu Y, Stanch M (1993) Metabolic and hormonal reactions during training in junior oarsmen. Int J Sports Med 14(Suppl. 1): S24–S28PubMedGoogle Scholar
  59. 59.
    Stone MH, Keith RE, Kearney JT, Fleck SJ, Wilson GD, Triplett NT (1991) Overtraining: a review of the signs, symptoms and possible causes. J Appl Sport Sci Res 5:35–50Google Scholar
  60. 60.
    Stray-Gundersen J, Videman T, Snell PG (1986) Changes in selected objective parameters during overtraining. Med Sci Sports Exerc 18:S54–S55Google Scholar
  61. 61.
    Stupnicki R, Obminski Z (1992) Glucocorticoid responses to exercise as measured by serum and salivary cortisol. Eur J Appl Physiol 65:546–549CrossRefGoogle Scholar
  62. 62.
    Stupnicki R, Obuchowicz-Fidelus B, Jedlikowski P, Kuslewicz A (1992) Serum cortisol, growth hormone and physiological responses to laboratory exercise in male and female rowers. Biol Sport 9:17–23Google Scholar
  63. 63.
    Sutton JR, Coleman MJ, Casey JH (1978) Testosterone production rate during exercise. In: Landry F, Orban WA (eds) 3rd International Symposium on Biochemistry of Exercise. Symposia Specialists Miami: 227–234Google Scholar
  64. 64.
    Tabata I, Atomi Y, Misyashita M (1989) Biphasic change of serum cortisol concentration in the morning during high-intensity physical training in man. Horm Metab Res 21:218–219PubMedGoogle Scholar
  65. 65.
    Tchaikovsky VS, Astratenkova IV, Bashirina OB (1986) The effect of exercise on the content and receptor of the steroid hormones in rat skeletal muscle. J Steroid Biochem 24:251–253PubMedCrossRefGoogle Scholar
  66. 66.
    Toode K, Smirnova T, Tendegolskis Z, Viru A (1993) Growth hormone action on blood glucose, lipids and insulin during exercise. Biol Sports 10:99–105Google Scholar
  67. 67.
    Tremblay MS, Chu SY, Mureika R (1995) Methodological and statistical considerations for exercise-related hormone evaluation. Sports Med 20:90–108PubMedGoogle Scholar
  68. 68.
    Ullman M, Oldfors A (1986) Effects of growth hormone on skeletal muscle. I Studies on normal adult rats. Acta Physiol Scand 135:531–536Google Scholar
  69. 69.
    Urhausen A, Gabriel H, Kindermann W (1995) Blood hormones as markers training stress and overtraining. Sports Med 20:351–376Google Scholar
  70. 70.
    Urhausen A, Kindermann W (1992) Biochemical monitoring of training. Clin J Sports Med 2:52–61CrossRefGoogle Scholar
  71. 71.
    Urhausen A, Kindermann W (1994) Monitoring of training by determination of hormone concentration in the blood-review and perspectives. In: Liesen H, Weiß M, Baum M (eds) Regulations und Repairmechanismen. Deutscher Ärzte-Verlag Köln: 551–554Google Scholar
  72. 72.
    Urhausen A, Kullmer T, Kindermann W (1987) A 7-week follow-up study of the behaviour of testosterone and cortisol during the competition period in rowers. Eur J Appl Physiol 56:528–533CrossRefGoogle Scholar
  73. 73.
    Vaernes R, Ursin H, Darragh A (1982) Endocrine response patterns and psychological correlates. J Pychosom Res 26:123–131CrossRefGoogle Scholar
  74. 74.
    Vanhelder T, Radomski MW (1989) Sleep deprivation and the effect on exercise performance. Sports Med 7:235–247PubMedGoogle Scholar
  75. 75.
    Varrik E, Viru A, Ööpik V, Viru M (1992) Exercise-induced catabolic responses in various muscle fibers. Can J Sports Sci 17:125–128Google Scholar
  76. 76.
    Vervoorn C, Quist L, Vermulst L, De Vries W, Thijssen HH (1991) The behaviour of the plasma free testosterone/cortisol ratio during a season of elite rowing training. Int J Sports Med 12:257–263PubMedGoogle Scholar
  77. 77.
    Vervoorn C, Vermulst L, Koppenschaar HPE, Erich WBM (1992) Seasonal changes in performance and free testosterone: cortisol ratio of elite female rowers. Eur J Appl Physiol 64:14–21CrossRefGoogle Scholar
  78. 78.
    Vining RF, McGinley RA, Makarytis JJ, Ho KY (1983) Salivary cortisol: A better measure of adrenal cortical function than serum cortisol. Ann Clin Biochem 20:329–335PubMedGoogle Scholar
  79. 79.
    Viru A (1995) Adaptation in Sports Training. CRC Press Boca Ration, Ann Arbor, London, TokyoGoogle Scholar
  80. 80.
    Viru A (1991) Adaptive regulation of hormone interaction with receptor. Exp Clin Endocrin 97:13–28Google Scholar
  81. 81.
    Viru A (1985) Hormones in Muscular Activity. Vol.2. Adaptive Effects of Hormones in Exercise. CRC Press Boca Raton FIGoogle Scholar
  82. 82.
    Viru A (1994) Molecular cellular mechanisms of training effects. J Sports Med Fitness 34:309–322Google Scholar
  83. 83.
    Viru A (1984) The mechanisms of training effects: A hypothesis. Int J Sports Med 5:219–227PubMedGoogle Scholar
  84. 84.
    Viru A, Karelson K, Smirnova T (1992) Stability and variability in hormone responses to prolonged exercise. Int J Sports Med 13:230–235PubMedGoogle Scholar
  85. 85.
    Viru A, Kostina L, Zhurkina L (1988) Dynamics of cortisol and somatotropin contents in blood of male and female sportsmen during their intensive training. Fiziol zhurn (Kiev), 34(4):61–66Google Scholar
  86. 86.
    Viru A, Litvinova L, Viru M, Smirnova T (1994) Glucocorticoids in metabolic control during exercise: alanine metabolism. J Appl Physiol 76:801–805PubMedGoogle Scholar
  87. 87.
    Viru A, Ööpik V (1989) Anabolic and catabolic responses to training. In: Kvist M (ed) Paavo Nurmi Congress Book. The Finnish Society of Sports Medicine Turku: 55–56Google Scholar
  88. 88.
    Viru A, Smirnova T (1985) Involvement of protein synthesis in the action of glucocorticoids on the working capacity of adrenalectomized rats. Int J Sports Med 6:225–228PubMedGoogle Scholar
  89. 89.
    Viru A, Smirnova T, Karelson K, Snegovskaya V, Viru M (1996) Determinants and modulators of hormonal responses to exercise. Biol Sport 13:169–187Google Scholar
  90. 90.
    Viru A, Tendzegolskis Z, Smirnova T (1990) Changes of β-endorphin level in blood during prolonged exercise. Endocrinol exp 24:63–68PubMedGoogle Scholar
  91. 91.
    Viru A, Viru M (1997) Adaptivity changes in athletes. Coaching and Sport Sci J 2(2):26–35Google Scholar
  92. 92.
    Weitzman ED (1976) Circadian rhythms and episodic hormone secretion. Ann Rev Med 27:225–243PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • Atko Viru
    • 1
  • Mehis Viru
    • 1
  1. 1.Institute of Exercise BiologyUniversity of TartuTartuEstonia

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