Neuroendocrine System

Exercise Overload and Regeneration
  • A. C. Hackney


The physiological systems of the human body are placed under a great deal of stress during the process of exercise training. Within elite athletes this stress can be of enormous levels because of the volume and intensity of work they perform in their training regimes . When training stress is of an appropriate level then there is a positive adaptation in the human organism and typically physical performance improves. However, the converse can also be true—inappropriate levels of stress can result in negative, maladaptations and declines in physical performance. In the adaptive process to exercise training, it is well known that there is a need for rest and recovery from the stress of training. If this is not allowed, repetitive exposure to what would normally be an appropriate level of stress can become inappropriate in nature. When an inappropriate level of training stress is imposed upon the athlete there is a great likelihood of the athlete developing the “overtraining syndrome”. Once this occurs, physical performance can decline so severely that the athlete’s competitive season may be over.


Growth Hormone Luteinizing Hormone Exercise Training Resistance Exercise Hormonal Response 
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  1. 1.
    Aakvaag A, Sand T, Opstad PK, Fonnum F (1978) Hormonal changes in serum in young men during prolonged physical strain. Eur J Appl Physiol 39: 283–291CrossRefGoogle Scholar
  2. 2.
    Alen A, Parkarinen A, Hakkinen K, Komi P (1988) Responses of serum androgenic-anabolic and catabolic hormones to prolonged strength training. Int J Sport Med 9: 229–233Google Scholar
  3. 3.
    Arce JC, DeSouza MJ (1983) Exercise and male factor infertility. Sports Med 15: 146–169Google Scholar
  4. 4.
    Astrand PO, Rodahl K (1970) Textbook of work physiology. McGraw-Hill Book Co. New York: 112–404Google Scholar
  5. 5.
    Barron J, Noakes TD, Levy W, Smith C (1985) Hypothalamic dysfunction in overtrained athletes. J Clin Endocrinol Metab 60: 803–806PubMedGoogle Scholar
  6. 6.
    Barwich D, Klett G., Eckert W, Weicker H. (1989) Exercise-induced lipolysis in patients with central Cushing’s disease. Int J Sports Med 1: 120–126Google Scholar
  7. 7.
    Berchold P, Berger M, Cuppers HJ, Herrmann J, Nieschlag E, Rudorff K, Zimmerman H, Kruskemper HL (1978) Non-glucoregulatory hormones (T4, T3, rT3, TSH and testosterone) during physical exercise in juvenile type diabetics. Horm Metab Res 10: 269–273Google Scholar
  8. 8.
    Bloom SR, Johnson RH, Park DM, Rennie MJ, Sulaman WR (1976) Differences in the metabolic and hormonal response to exercise between racing cyclists and untrained individuals. J Physiol (Lond.) 258:1–18Google Scholar
  9. 9.
    Bonifazi M, Bela E, Carl G, Lodi L, Martelli G, Zhu B, Lupo C (1995) Influence of training on the response of androgen plasma concentration to exercise in swimmers. Eur J Appl Physiol 70: 109–114CrossRefGoogle Scholar
  10. 10.
    Boyden TW, Paramenter R, Stanforth P, Rotkis TC, Wilmore J (1984) Impaired gonadotropin response to gonadotrophin-releasing hormone stimulation in endurance trained women. Fertil Steril 41: 359–363PubMedGoogle Scholar
  11. 11.
    Brandenberger G, Follenius M (1975) Influence of timing and intensity of muscle exercise on temporal patterns of plasma cortisol levels. J Clin Endocrinol Metab 40: 845–849PubMedGoogle Scholar
  12. 12.
    Brisson G, Nolle MA, Desharnaris D, Tanka M (1980) A possible submaximal exercise-induced hyothalamo-hypothyseal stress. Horm Metab Res 12: 201–205PubMedGoogle Scholar
  13. 13.
    Brooks GA, Fahey TD, White TP (1996) Exercise physiology: Human bioenergetics and its application. Mayfield Publishing Co. Toronto: 144–172Google Scholar
  14. 14.
    Bunt J (1986) Hormonal alterations due to exercise. Sports Med 3: 331–345PubMedGoogle Scholar
  15. 15.
    Buono MJ, Yeager JE, Hodgdon J (1986) Plasma adrenocorticotropin and cortisol responses to brief high-intensity exercise in human. J Appl Physiol 61: 1337–1339PubMedGoogle Scholar
  16. 16.
    Costill DL, Thomas R, Robergs RA, Pascoe D, Lambert C, Barr S, Fink WJ (1991) Adaptations to swimming training: influence of training volume. Med Sci Sport Exerc 23(3): 371–377Google Scholar
  17. 17.
    Cumming DC, Wall SR, Galbraith MA, Belcastro A (1987) Reproductive hormonal responses to resistance exercise. Med Sci Sport Exerc 19: 234–238Google Scholar
  18. 18.
    Dale E, Gerlach D, Whilhite AL (1979) Menstrual dysfunction in distance runners. Obstet Gynecol 54: 47–53PubMedCrossRefGoogle Scholar
  19. 19.
    Despopoulos A, Silbernagi S (1991) Color Atlas of Physiology. Georg Thieme Verlag Stuttgart: 232–271Google Scholar
  20. 20.
    Duclos M, Corcuff JB, Rashedi M, Fougere B (1996) Does functional alterations of the gonadotropic axis occur in endurance trained athletes during after exercise? A preliminary study. Eur J Applied Physiol 73: 427–433CrossRefGoogle Scholar
  21. 21.
    Davies CTM, Few J (1972) Effect of exercise on adrenocortical function. J Appl Physiol 35: 688–691Google Scholar
  22. 22.
    Dessypris A, Kuoppasalmi H, Adlercreutz H (1976) Plasma cortisol testosterone androstenedione and luteinizing hormone (LH) in a non-competitive marathon run. J Steroid Biochem 7: 33–37PubMedCrossRefGoogle Scholar
  23. 23.
    Farrell PA, Kjaer M, Bach FW, Galbo H (1987) Beta-endorphin and adrenocorticotropin response to supra-maximal treadmill exercise in trained and untrained males. Acta Physiol Scand 130: 619–625PubMedGoogle Scholar
  24. 24.
    Fellmann N, Coudert J, Jarrige J, Bedu M.m Denis C, Boucher D, Lacour JR (1985) Effects of endurance training on the androgenic response to exercise in man. Int J Sports Med 6(4): 215–219PubMedGoogle Scholar
  25. 25.
    Fry AC, Kraemer W (1997) Resistance exercise overtraining and overreaching: neuroendocrine responses Sports Med 23: 106–129PubMedGoogle Scholar
  26. 26.
    Fry RW, Morton AR, Garcia-Webb P, Crawford GPM, Keast D (1992) Biological responses to overload training in endurance sports. Eur J Appl Physiol 335–344Google Scholar
  27. 27.
    Fry RW, Morton AR, Keast D (1991) Overtraining in athletes: an update. Sports Med 12: 32–65PubMedGoogle Scholar
  28. 28.
    Fry RW, Morton AR, Garcia-Webb P, Keast D (1991) Monitoring exercise stress by changes in metabolic and hormonal responses over a 24-h period. Eur J Appl Physiol 63: 228–234CrossRefGoogle Scholar
  29. 29.
    Galbo H (1983) Hormonal and metabolic adaptation to exercise. Stuttgart Georg Thieme Verlag: 2–117Google Scholar
  30. 30.
    Galbo H, Hummer L, Peterson IB, Christensen NJ, Bie W (1977) Thyroid and testicular hormonal responses to graded and prolonged exercise in men. Eur J Appl Physiol 36: 101–106CrossRefGoogle Scholar
  31. 31.
    Galbo H, Kjaer M, Mikines KJ (1989) Neurohormonal system. In: Skinner J, Corbin, Landers D, Martin P, Wells CL (eds) Future directions in exercise ad sport science research. Human Kinetics Publishers Champaign: 39–345Google Scholar
  32. 32.
    Gary AB, Telford RD, Weidemann MJ (1993) Endocrine response to intense interval exercise. Eur J Appl Physiol 66: 366–371CrossRefGoogle Scholar
  33. 33.
    Gastmann U, Lehmann M, Fleck J, Jeschke D, Keul J (1993) Influence of a 6-week controlled training on behavior of catecholamines and catecholamine sensitivity in recreational athletes In: Tittel K, Arndt KH, Hollmann W (eds) Sportsmedizin: gestern-heute-morgen Barth Leipzig: 191–193Google Scholar
  34. 34.
    Gawel MJ, Alaghband-Zadeh J, Park DM, Rose FC (1979) Exercise and hormonal secretion. Postgraduate Med J 55: 373–376Google Scholar
  35. 35.
    Goldfarb A, Hatfield BD, Potts J, Armstrong D (1991) Beta-endorphin time course of response to intensity of exercise: effect of training status. Int J Sports Med 12: 264–268PubMedCrossRefGoogle Scholar
  36. 36.
    Griffin JE. (1996) The thyroid. In: Griffin JE, Odjeda JE (eds) Textbook of endocrine physiology. 3rd ed. Oxford University Press New York: 260–283Google Scholar
  37. 37.
    Guezennec Y, Leger F, Hostr FL, Aymonud M, Pesquies PC (1986) Hormonal and metabolic responses to weightlifting training sessions. Int J Sport Med 7: 100–105Google Scholar
  38. 38.
    Hackney AC (1989) Endurance training and testosterone levels. Sports Med 8: 117–127PubMedGoogle Scholar
  39. 39.
    Hackney AC (1996) The male reproductive system and endurance exercise. Med Sci Sport Exerc 28: 180–189Google Scholar
  40. 40.
    Hackney AC, Fahrner CL, Stupnicki R (1997) Reproductive hormonal responses to maximal exercise in endurance trained men with low testosterone levels. Exp Clin Endocrinol Diabetes 105: 291–295PubMedCrossRefGoogle Scholar
  41. 41.
    Hackney AC, Pearman SN, Nowacki JM (1990) Physiological profiles of overtrained and stale athletes: a review. J Appl Sport Psych 2: 21–33Google Scholar
  42. 42.
    Hackney AC, Premo MC, McMurray RG (1995) Influence of aerobic and anaerobic exercise on the relationship between reproductive hormones in men. J Sport Sci 13: 305–311Google Scholar
  43. 43.
    Hackney AC, Ness RJ, Schrieber A (1989) Effects of endurance exercise on nocturnal hormone concentrations in males. Chronobiol 6: 341–346CrossRefGoogle Scholar
  44. 44.
    Hackney AC, Sinning WE, Bruot BC (1990) Hypothalamic-pituitary-testicular axis function in endurance-trained males. Int J Sports Med 11: 298–303PubMedGoogle Scholar
  45. 45.
    Hackney AC, Feith S, Pozos R, Seale J (1995) Effects of high altitude and cold exposure on resting thyroid hormone concentrations. Aviat Space Environ Med 66: 325–329PubMedGoogle Scholar
  46. 46.
    Hackney AC, Gulledge TP (1994) Thyroid responses during an 8 hour period following aerobic and anaerobic exercise. Physiol Res 43: 1–5PubMedGoogle Scholar
  47. 47.
    Hackney AC, Hodgdon J (1992) Thyroid hormone changes during military field operations: Effects of cold exposure in the Arctic. Aviat Space Environ Med 63: 606–611PubMedGoogle Scholar
  48. 48.
    Hackney AC, Hodgdon J, Hesslink R, Trygg K (1995) Thyroid hormone responses to military winter exercises in the Arctic Region. Arct Med Res 54: 82–90Google Scholar
  49. 49.
    Hackney AC, Sharp RL, Runyan W, Ness RJ (1989) Relationship of prolactin and testosterone changes in males during intensive training Br J Sport Med 23: 194Google Scholar
  50. 50.
    Hackney AC, Sinning WE, Bruot BC (1988) Comparison of resting reproductive hormonal profiles in endurance trained and untrained men. Med Sci Sports Exerc 20: 60–65PubMedCrossRefGoogle Scholar
  51. 51.
    Hooper SL, Traeger-MacKinnon L, Gordon RD, Bachmann AW (1993) Hormonal responses of elite swimmers to overtraining. Med Sci Sports Exerc 25: 741–747PubMedGoogle Scholar
  52. 52.
    Houmard J, Costill D, Mitchell J, Park S, Fink W, Burns J (1990) Testosterone, cortisol, and creatine kinase levels in male distance runners during reduced training. Int J Sport Med 11: 41–45Google Scholar
  53. 53.
    Jost J, Weiss M, Weicker H (1989) Unterschiedliche regulation des adrenergeb rezeptorsystems in verschiedenen trainingsphasen von schwimmern und langstreckenläufen In: Böning D, Braumann KM, Busse MW, Maassen N, Schmidt W (Hrsg) Sport Rettng order Risiko für die Gesundheit Deutscher Ärzteverlag Köln: 141–145Google Scholar
  54. 54.
    Kern W, Perras B, Wodick R, Fehm HL, Born J (1995) Hormonal secretion during nighttime sleep indicating stress of daytime exercise. J Appl Physiol 79: 1461–1468PubMedGoogle Scholar
  55. 55.
    Kindermann W, Schmitt W (1985) Verhalten von testosteron im blutserum bei körperarbeit unterschiedlicher dauer und intensität. Deutsch Z Sportmed 36: 99–104Google Scholar
  56. 56.
    Kirwan JP, Costill DL, Flynn MG (1988) Physiological responses to successive days of intense training in competitive swimmers. Med Sci Sport Exerc 20: 255–259CrossRefGoogle Scholar
  57. 57.
    Kjäer L, Secher NH, Bach FW, Sheikh S, Galbo H (1989) Hormonal and metabolic responses to exercise in humans: effects of sensory nervous blockage. Am J Physiol 257: 95–100Google Scholar
  58. 58.
    Kjaer M, Secher NH, Bach FW, Galbo H, Reeves DR, Mitchell JH (1991) Hormonal, metabolic and cardiovascular responses to static exercise in man: influence of epidural anesthesia. Am J Physiol 261: E214–E220PubMedGoogle Scholar
  59. 59.
    Kraemer RR, Heleniak RJ, Tryniecki L, Kraemer G, Okazaki N, Castracane V (1995) Follicular and luteal phase hormonal responses to low-volume resistive exercise. Med Sci Sports Exerc 27: 809–817PubMedGoogle Scholar
  60. 60.
    Kraemer WJ (1988) Endocrine response to resistance exercise. Med Sci Sports Exerc 20: S152–S157PubMedCrossRefGoogle Scholar
  61. 61.
    Kraemer WJ, Patton JF, Knuttgen HG, Marchitelli LJ, Cruthirds C, Damokosh A, Harman E, Frykman P, Dziados JE (1989) Hypothalamic-pituitary-adrenal responses to short-duration high-intensity cycle exercise. J Appl Physiol 66: 161–166PubMedCrossRefGoogle Scholar
  62. 62.
    Kuoppasalmi K, Naveri N, Harkonen M, Adlercreutz H (1980) Plasma cortisol, androstenedione, testosterone and LH in running exercise of different intensities. Scand J Clin Lab Invest 40: 403–409PubMedGoogle Scholar
  63. 63.
    Kuoppasalmi K, Naveri N, Kosunen K, Harkonen M, Adlercreutz H (1981) Plasma steroid levels in muscular exercise. In: Poortmans J, Niset G (eds) Biochemistry of Exercise IV-B University Park Press Baltimore: 149–160.Google Scholar
  64. 64.
    Kuipers H, Keizer HA (1988) Overtraining in elite athletes. Sports Med 6: 79–92PubMedGoogle Scholar
  65. 65.
    Lehmann M, Foster C, Keul J (1993) Overtraining in endurance athletes: a brief review. Med Sci Sports Exerc 25: 854–862PubMedCrossRefGoogle Scholar
  66. 66.
    Lehmann M, Gastmann U, Steinacker J, Heinz JN, Brouns F (1995) Overtraining in endurance sports: a short review. Med Sport Boh Slov 4: 1–6Google Scholar
  67. 67.
    Lehmann M, Knizia K, Gastmann U, Petersen G, Khalaf A, Bauer S, Kerp L, Keul J (1993) Influence of 6-week 5 days per week training on pituitary function in recreational athletes. Br J Sports Med 27: 186–192PubMedGoogle Scholar
  68. 68.
    Lehmann M, Lormes W, Opitz-Gress A, Steinacker J, Netzer N, Foster C, Gastmann U (1997) Training and overtraining: an overview and experimental results in endurance sport. J Sports Med Phys Fit 37: 7–17Google Scholar
  69. 69.
    Lehmann M, Schnee W, Scheu R, Stockhausen W, Bachl B (1992) Decreased nocturnal catecholamine excretion: parameter for an overtraining syndrome in athletes? Int J Sports Med 13: 236–242PubMedGoogle Scholar
  70. 70.
    Lukaszewska J, Biczoswa B, Hobilewicz D, Wilk M, Obuchowicz-Fibelus B (1976) Effect of physical exercise on plasma cortisol and growth hormone levels in young weight lifters. Endokrynol Pol 2: 149–158Google Scholar
  71. 71.
    MacConnie S, Barkan A, Lampman RM, Schork M, Beitins IZ (1986) Decreased hypothalamic gonadotrophin-releasing hormone secretion in male marathon runners. N Engl J Med 315: 411–416PubMedCrossRefGoogle Scholar
  72. 72.
    McMurray RG, Eubanks TK, Hackney AC (1995) Nocturnal hormonal responses to resistance exercise. Eur J Appl Physiol 72: 121–126CrossRefGoogle Scholar
  73. 73.
    McMurray RG, Forsythe WA, Mar MH, Hardy CJ (1987) Exercise intensity-related responses of beta-endorphin and catecholamines. Med Sci Sports Exerc 19: 570–574PubMedGoogle Scholar
  74. 74.
    Melchionda A, Clarkson P, Denko C, Freedson P, Graves J, Katch F (1984) The effect of local isometric exercise on serum levels of beta-endorphin/beta-lipotropin. Phys Sportsmed 12: 102–109Google Scholar
  75. 75.
    Morgan WP, Brown DR, Raglin JS, O’Connor PJ, Ellickson KA (1987) Psychological monitoring of overtraining and staleness. Br J Sports Med 21: 107–114PubMedGoogle Scholar
  76. 76.
    Morville R, Pesquies PC, Guezennec CY, Serrurier BD, Guignard M (1879) Plasma variations in testicular and adrenal androgens during prolonged physical exercise in man. Ann Endocrinol (Paris) 40: 501–510Google Scholar
  77. 77.
    Nazar K, Jezova D, Kowalik-Borowka E (1989) Plasma vasopressin, growth hormone and ACTH responses to static handgrip in healthy subjects. Eur J Appl Physiol 58: 400–404CrossRefGoogle Scholar
  78. 78.
    Nicklas BJ, Ryan AJ, Treuth MM, Harman SH, Blackman MR, Hurley BF, Rogers MA (1995) Testosterone, growth hormone, and IGF-I responses to acute and chronic resistive exercise in men aged 55–70 yr. Int J Sports Med 16: 445–450PubMedCrossRefGoogle Scholar
  79. 79.
    Opstad PK, Aakvaag A (1983) The effect of sleep deprivation on the plasma levels of hormones during prolonged physical strain and calorie deficiency. Eur J Appl Physiol 51: 97–107CrossRefGoogle Scholar
  80. 80.
    Pestell RG, Hurley DM, Vandongen R (1989) Biochemical and hormonal changes during a 100 km ultramarathon. Clin Exp Pharmacol Physiol 16: 353–361PubMedCrossRefGoogle Scholar
  81. 81.
    Rahkila P, Hakala E, Alen M, Salminen K, Laatikainen T (1988) Beta-endorphin and corticotropin release is dependent on a threshold intensity of running exercise in male endurance athletes. Life Sci 43: 551–557PubMedCrossRefGoogle Scholar
  82. 82.
    Remes K, Kuoppasalmi K, Adlercreutz H (1985) Effect of physical exercise and sleep deprivation on plasma androgen levels: modifying effect of physical fitness. Int J Sports Med 6: 131–135PubMedGoogle Scholar
  83. 83.
    Schwarz L, Kindermann W (1989) Beta-endorphin, catecholamines and cortisol during exhaustive endurance exercise. Int J Sports Med 10: 324–328PubMedGoogle Scholar
  84. 84.
    Shephard RJ, Sidney KH (1975) Effects of exercise on plasma growth hormone and cortisol levels in human subjects. In: Wilmore JH (ed) Exercise and Sport Sciences Reviews. Academic Press New York. 3: 1–31Google Scholar
  85. 85.
    Shepley B, MacDougall D, Cipriano N, Sutton JR, Tarnopolsky MA, Coates G (1992) Physiological effects of tapering in highly trained athletes. J Appl Physiol 72: 706–711PubMedGoogle Scholar
  86. 86.
    Stone MH, Byrd R, Johnson C (1984) Observations on serum androgen responses to short term resistance exercise in middle-aged sedentary males. Nat Str Cond Assoc J 5:40–65CrossRefGoogle Scholar
  87. 87.
    Stone M, Keith R, Kearney J, Fleck S, Wilson G, Triplett N (1991) Overtraining: a review of the signs symptoms and possible causes. J Appl Sport Sci Res 5: 35–50Google Scholar
  88. 88.
    Stray-Gundersen J, Videman T, Snell P (1986) Changes in selected objective parameters during overtraining. Med Sci Sports Exerc 18 (Suppl): 54Google Scholar
  89. 89.
    Storzo GA (1988) Opioids and exercise, and update. Sports Med 7: 109–184Google Scholar
  90. 90.
    Sutton JR, Coleman MJ, Casey J (1973) Androgen responses to physical exercise. Br Med J 1: 520–522PubMedGoogle Scholar
  91. 91.
    Terjung RL, Tipton CM (1971) Plasma thyroxine and TSH levels during submaximal exercise in humans. Am J Physiol 220: 1840–1845PubMedGoogle Scholar
  92. 92.
    Theintz GE (1994) Endocrine adaptation to intensive physical training during growth. Clin Endocrinol 41: 267–272Google Scholar
  93. 93.
    Tharp GD (1975) The role of glucocorticoids in exercise. Med Sci Sports 7: 6–11PubMedGoogle Scholar
  94. 94.
    Urhausen A, Gabriel H, Kindermann W (1995) Blood hormones as markers of training stress and overtraining. Sports Med 20: 251–276PubMedGoogle Scholar
  95. 95.
    Urhausen A, Kindermann W (1992) Biochemical monitoring of training. Clin J Sports Med 2: 52–61CrossRefGoogle Scholar
  96. 96.
    Urhausen A, Kindermann W (1994) Monitoring of training by determination of hormone concentration in the blood — review and perspectives. In: Liesen H, Weiß M, Baum M (eds) Regulations — und Repairmechanismen: Köln; Deutscher Ärzte-Verlag: 551–554Google Scholar
  97. 97.
    Urhausen A, Kullmer T, Kindermann W (1987) A 7-week follow-up study of the behavior of testosterone and cortisol during the competitive period in rowers. Eur J Appl Physiol 56: 528–533CrossRefGoogle Scholar
  98. 98.
    VanHouten M, Posner BI, Walsh RJ (1980) Radio-autographic identification of lactogen binding sites in rat medium eminence using 125I-human growth hormone: evidence for a prolactin “short-loop” feedback site. Exp Brain Res 38: 455–459CrossRefGoogle Scholar
  99. 99.
    Viru A (1992) Hormonal and metabolic foundations of training effects: sex differences. Medicina Dello Sport 45: 29–38Google Scholar
  100. 100.
    Viru A (1992) Plasma hormones and physical exercise. Int J Sports Med 13: 201–209PubMedGoogle Scholar
  101. 101.
    Viru A, Karelson K, Smirnova T (1992) Stability and variability in hormonal response to prolonged exercise. Int J Sports Med 13: 230–235PubMedGoogle Scholar
  102. 102.
    Viru A, Smirnova T (1982) Independence of physical working capacity from increased glucocorticoid level during short term exercise. Int J Sports Med 3: 80–83PubMedGoogle Scholar
  103. 103.
    Viru A (1985) Hormones in muscular activity: volume I — hormonal ensemble in exercise. CRC Press Boca Raton: 7–88Google Scholar
  104. 104.
    Viru A, Viru M (1997) Organism’s adaptivity in sports training. Medicina Sportiva 1: 45–50Google Scholar
  105. 105.
    Widmaier EP (1992) Metabolic feedback in mammalian endocrine systems. Horm Metab Res 24: 147–153PubMedGoogle Scholar
  106. 106.
    Wilkerson JE, Horvath SM (1980) Plasma testosterone during treadmill running. J Appl Physiol 49: 249–253PubMedGoogle Scholar
  107. 107.
    Winder WW, Hagberg JM, Hickson RR, Ehsani AA, McLane JA (1978) Time course of sympathoadrenergic adaptation to endurance exercise training in man. J Appl Physiol 45: 370–374PubMedGoogle Scholar
  108. 108.
    Winder WW, Hickson RC, Hagberg JM, Eshani AA, McLane JA (1979) Training-induced changes in hormonal and metabolic responses to submaximal exercise. J Appl Physiol 46: 766–771PubMedGoogle Scholar
  109. 109.
    Wirth A, Holm G, Lindstedt G, Lundberg PA, Bjorntorp P (1981) Thyroid hormones and lipolysis in physically trained rats. Metab 30: 237–241CrossRefGoogle Scholar
  110. 110.
    Wittert GA, Livesey J, Espiner E, Donald R (1996) Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans. Med Sci Sport Exerc 28: 1015–1019Google Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • A. C. Hackney
    • 1
  1. 1.Endocrine Section - Applied Physiology LaboratoryUniversity of North CarolinaChapel Hill

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