Early and late immunological changes in burn patients
Burn injury causes many defects in the mobility and functions of the two leukocyte subpopulations, granulocytes and lymphocytes, and these abnormalities have been described by many investigators as the cause of post-burn infection. Sakai (1974) has observed that the peripheral blood lymphocyte count is at the lowest normal limits during the first post-burn week, the count then gradually returning to normal. Arturson (1969) and Andrew (1970) have demonstrated that immediately after thermal injury all immunoglobulins in the patient serum are decreased and reach the lowest values at about 2 days post-trauma; the level then rises again to normal levels at the end of the first week for IgM, during the second week for IgA, IgG and IgE, and at the end of the first month for IgD.
KeywordsThermal Injury Mixed Lymphocyte Culture Leukocyte Subpopulation Lower Normal Limit Immune Modulate Agent
Unable to display preview. Download preview PDF.
- Alexander, J. W. (1979). Burns, A Team Approach. (Philadelphia: WB Saunders)Google Scholar
- Andrew, M. M. et al. (1970). The effect of thermal injury on serum immunoglobulins. Ann. Surg., 12, 965–969Google Scholar
- Daniels, J. C. et al. (1975). Lymphocyte responses of burn patients. South Med. J., 861–865Google Scholar
- Visentini, P. (1989). Extensive burn patient immunological problems. Annals of the Mediterranean Burns Club, 2, 185–189Google Scholar