Biological Effects of Targeted Gene Inactivation and Gene Transfer of the Coagulation and Fibrinolytic Systems in Mice

  • Peter Carmeliet
  • Désiré Collen
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Preservation of vascular integrity following traumatic or infectious challenges is essential for the survival of multicellular organisms. A major defense mechanism involves the formation of hemostatic plugs by activation of platelets and polymerization of fibrin. Initiation of the plasma coagulation system on exposure of blood to nonvascular cells is triggered by tissue factor (TF), which is expressed by a variety of cells surrounding the vasculature as a hemostatic envelope and which functions as a cellular receptor and cofactor for activation of the serine proteinase factor VII to VIIa [1]. This complex activates factor X directly or indirectly via activation of factor IX, resulting in the generation of thrombin-mediated conversion of fibrinogen to fibrin [2,3]. Thrombin and factor Xa produce a positive feedback stimulation of coagulation by activating factors VIII and V, which serve as membrane-bound receptors/cofactors for the proteolytic enzymes factors IXa and Xa, respectively [2,3].


Plasminogen Activator Tissue Factor Deficient Mouse Neointima Formation Dorsal Aorta 
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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Peter Carmeliet
  • Désiré Collen

There are no affiliations available

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