Plasminogen Activator Inhibitor-1

  • Daniel T. Eitzman
  • William P. Fay
  • David Ginsburg
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Fibrinolysis, the dissolution of fibrin clots, is an integral component of the hemostatic system that involves the concerted action of a complex system of zymogens, activators, and inhibitors [1]. Plasmin, the primary protease of the fibrinolysic system, digests fibrin, thereby converting insoluble clot to soluble fibrin degradation products. Plasmin formation is regulated, in large part, by plasminogen activators, which are responsible for converting the zymogen, plasminogen, to plasmin. The two major plasminogen activators in humans are tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Both types of activators are serine proteases that specifically convert plasminogen to the broad-specificity protease, plasmin, by cleaving a single peptide bond (Arg560-Val561) [1]. Plasmin, in turn, appears to participate in a multitude of biological processes, including vascular fibrinolysis [2], ovulation [3], inflammation [4], tumor metastasis


Plasminogen Activator Idiopathic Pulmonary Fibrosis Pulmonary Fibrosis Plasminogen Activator Inhibitor Hemolytic Uremic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Daniel T. Eitzman
  • William P. Fay
  • David Ginsburg

There are no affiliations available

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