Gene therapy for the vulnerable plaque

  • Douglas W. Losordo
  • Jeffrey M. Isner
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Rupture of coronary atherosclerotic plaque and subsequent formation of an occlusive intracoronary thrombus (Figure 410-1) are the major events precipitating acute coronary syndromes [1, 2, 3, 4, 5, 6]. The vulnerable plaque is smaller in size [7], richer in lipids [1],[2], and more infiltrated with macrophages [2,3,8, 9, 10] than the stable, fibromuscular lesion. Therefore, lowering the lipid and/or macrophage pools stored in the plaque may “stabilize” the plaque and reduce the incidence of plaque rupture [2,4, 5, 6]. Indeed, cholesterol-lowering trials have yielded a significant reduction in acute cardiac events [11, 12, 13, 14, 15, 16, 17, 18]. Antithrombotic therapies may further prevent acute coronary syndromes by altering the consequences of plaque rupture [4].


Gene Therapy Gene Transfer Acute Coronary Syndrome Plaque Rupture Familial Hypercholesterolemia 
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© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Douglas W. Losordo
  • Jeffrey M. Isner

There are no affiliations available

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