Anticoagulation Monitoring for Percutaneous Transluminal Coronary Angioplasty

  • James J. Ferguson
  • James M. Wilson
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Percutaneous transluminal coronary angioplasty (PTCA) relieves coronary obstruction through mechanical disruption of atherosclerotic lesions. It results in focal, traumatic injury, and loss of endothelial integrity, and is an intense stimulus for the formation of thrombus. Thrombus formation at the site of injury may result in reocclusion of the treated vessel and is thought to be a major factor contributing to the process of restenosis. Evidence from the cardiopulmonary bypass literature provides a strong argument that the intensity of anticoagulation influences the frequency with which thrombotic complications may develop. A growing body of evidence suggests that this is true for catheter-based intervention as well. As a result, patients are routinely anticoagulated with intravenous heparin during and immediately after angioplasty, and the degree or intensity of anticoagulation is frequently monitored during PTCA. This chapter presents current views on monitoring the efficacy and adequacy of anticoagulation for catheter-based interventional procedures.


Intracoronary Thrombus Sheath Removal Anticoagulation Monitoring Abrupt Closure Abrupt Vessel Closure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 1997

Authors and Affiliations

  • James J. Ferguson
  • James M. Wilson

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