Markers of Coronary Recanalization after Thrombolysis

  • Dana R. Abendschein
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Rapid assessment of coronary patency in patients receiving intravenous fibrinolytic agents for the treatment of acute myocardial infarction is needed to identify those in whom adequate and sustained patency has not been achieved who could benefit from secondary mechanical interventions (e.g., coronary angioplasty and surgical revascularization). Because delayed initiation of secondary interventions will impede salvage of ischemic myocardium, markers chosen to assess the success of fibrinolytic therapy should have (1) sensitivity to coronary recanalization within minutes of its occurrence, facilitating prospective diagnosis; (2) rapidity for virtual on-line acquisition of results; and (3) specificity for persistent and complete recanalization, because those patients exhibiting transitory or incomplete recanalization may benefit from additional interventions as much as those with persistent arterial occlusion. Among these qualities, high specificity for arteries potentially in need of additional intervention is the most important, even if a modest number of patients with patent vessels are falsely identified as having an occluded artery.


Acute Myocardial Infarction Creatine Kinase Thrombolytic Therapy Fibrinolytic Therapy Fibrinolytic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 1997

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  • Dana R. Abendschein

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