Markers of Thrombosis and Fibrinolysis

  • L. Veronica Lee
  • Dana R. Abendschein
  • Paul R. Eisenberg
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Thrombosis plays a central role in the pathogenesis of acute coronary syndromes. Currently available therapies, which possess primarily antithrombotic and fibrinolytic properties, have improved the clinical outcome of patients with unstable angina and myocardial infarction. However, because of residual thrombosis, a significant proportion of patients with acute coronary syndromes develop complications such as reocclusion, reinfarction, recurrent ischemia, and stenosis, with clinical manisfestations ranging from stable angina to death. We currently lack critical information regarding the balance between thrombosis and fibrinolysis that would help guide the development of short-term, long-term, and preventive treatments. Plasma markers of thrombosis and fibrinolysis are likely to be crucial to the development and use of current and future therapeutic approaches. The following is an overview of some currently available and novel assays for thrombotic and fibrinolytic activity, and recent clinical data on their potential role in the assessment of acute coronary syndromes and in guiding therapy.


Plasminogen Activator Tissue Factor Deep Venous Thrombosis Tissue Plasminogen Activator Tissue Factor Pathway Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • L. Veronica Lee
  • Dana R. Abendschein
  • Paul R. Eisenberg

There are no affiliations available

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