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Markers of Thrombosis and Fibrinolysis

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Book cover Textbook of Coronary Thrombosis and Thrombolysis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 193))

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Abstract

Thrombosis plays a central role in the pathogenesis of acute coronary syndromes. Currently available therapies, which possess primarily antithrombotic and fibrinolytic properties, have improved the clinical outcome of patients with unstable angina and myocardial infarction. However, because of residual thrombosis, a significant proportion of patients with acute coronary syndromes develop complications such as reocclusion, reinfarction, recurrent ischemia, and stenosis, with clinical manisfestations ranging from stable angina to death. We currently lack critical information regarding the balance between thrombosis and fibrinolysis that would help guide the development of short-term, long-term, and preventive treatments. Plasma markers of thrombosis and fibrinolysis are likely to be crucial to the development and use of current and future therapeutic approaches. The following is an overview of some currently available and novel assays for thrombotic and fibrinolytic activity, and recent clinical data on their potential role in the assessment of acute coronary syndromes and in guiding therapy.

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  1. L. Veronica Lee
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  2. Dana R. Abendschein
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  3. Paul R. Eisenberg
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Editors and Affiliations

  1. Cardiovascular Thrombosis Research Center, USA

    Richard C. Becker M.D. (Director) (Director)

  2. Coronary Care Unit, University of Massachusetts Medical School, Worcester, Massachusetts

    Richard C. Becker M.D. (Director) (Director)

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© 1997 Kluwer Academic Publishers

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Lee, L.V., Abendschein, D.R., Eisenberg, P.R. (1997). Markers of Thrombosis and Fibrinolysis. In: Becker, R.C. (eds) Textbook of Coronary Thrombosis and Thrombolysis. Developments in Cardiovascular Medicine, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33754-8_34

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  • DOI: https://doi.org/10.1007/978-0-585-33754-8_34

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