Early Diagnosis of Myocardial Infarction with MB-CK Subforms

  • Robert Roberts
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Caring for patients with acute myocardial infarction (AMI) in a dedicated critical care unit was introduced in 1962 and over the next decade became widespread throughout North America and Europe. There was a significant reduction in mortality from between 30% and 35% to about 20% within 5-6 years of introducing the coronary care unit (CCU). As these results became available and more knowledge accrued of the mechanisms involved with sudden death and cardiac failure, it became the accepted norm for patients with AMI to be admitted to the CCU. However, due to the lack of distinguishing features of chest pain and the lack of diagnostic specificity of the electrocardiogram (ECG), it was often necessary to admit the patient to the CCU to subsequently exclude myocardial infarction. Initially the diagnostic enzymatic markers performed in the CCU consisted of serum glutamic oxaloacetic transaminase (SCOT), lactic dehydrogenase (LDH), and creatine kinase (CK), which were performed daily for 3 days for exclusion of infarction


Acute Myocardial Infarction Creatine Kinase Emergency Room Acute Myocardial Infarction Coronary Care Unit 
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© Kluwer Academic Publishers 1997

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  • Robert Roberts

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