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The Scientific Basis and Rationale For Early Thrombolytic Therapy

  • Arie Roth
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)

Abstract

There are vast amounts of data that support the use of thrombolytic treatment in evolving acute myocardial infarction, and the evidence to justify early treatment is substantial. In the landmark GISSI trial [1], the administration of streptokinase within the first 3 hours was associated with a remarkable improvement in mortality (12.0% controls vs. 9.2% streptokinase), whereas in those treated within the first hour, mortality was reduced in as much as 47% (15.4% controls vs. 8.2% streptokinase). A similar relation with time was shown in the Second International Study of Infarct Survival (ISIS-2) [2]: Treatment within the first hour resulted in 13.4% mortality with placebo and 8.1% with streptokinase treatment.

Keywords

Acute Myocardial Infarction Infarct Size Left Ventricular Function Thrombolytic Therapy Thrombolytic Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Kluwer Academic Publishers 1997

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  • Arie Roth

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