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Textbook of Coronary Thrombosis and Thrombolysis pp 335–344Cite as

The Scientific Basis and Rationale For Early Thrombolytic Therapy

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 193))

Abstract

There are vast amounts of data that support the use of thrombolytic treatment in evolving acute myocardial infarction, and the evidence to justify early treatment is substantial. In the landmark GISSI trial [1], the administration of streptokinase within the first 3 hours was associated with a remarkable improvement in mortality (12.0% controls vs. 9.2% streptokinase), whereas in those treated within the first hour, mortality was reduced in as much as 47% (15.4% controls vs. 8.2% streptokinase). A similar relation with time was shown in the Second International Study of Infarct Survival (ISIS-2) [2]: Treatment within the first hour resulted in 13.4% mortality with placebo and 8.1% with streptokinase treatment.

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  1. Arie Roth
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  1. Cardiovascular Thrombosis Research Center, USA

    Richard C. Becker M.D. (Director) (Director)

  2. Coronary Care Unit, University of Massachusetts Medical School, Worcester, Massachusetts

    Richard C. Becker M.D. (Director) (Director)

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Roth, A. (1997). The Scientific Basis and Rationale For Early Thrombolytic Therapy. In: Becker, R.C. (eds) Textbook of Coronary Thrombosis and Thrombolysis. Developments in Cardiovascular Medicine, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33754-8_27

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