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Chemistry, Pharmacokinetics, and Pharmacodynamics of T-PA, TNK and DSPA Alpha 1

  • Chapter
Textbook of Coronary Thrombosis and Thrombolysis

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 193))

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Abstract

Tissue-type plasminogen activator (t-PA), the principal physiological human plasminogen activator, has been expressed in large quantities by recombinant technologies and, thus, has been available for therapeutic use for almost a decade. Despite the initial expectations, subsequent experience with this substance has somewhat reduced clinicians’ early enthusiasm; as a result, attempts have been made to engineer the molecule and to search for alternate and better plasminogen activators.

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  1. Steffen P. Christow
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  2. Dietrich C. Gulba
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  1. Cardiovascular Thrombosis Research Center, USA

    Richard C. Becker M.D. (Director) (Director)

  2. Coronary Care Unit, University of Massachusetts Medical School, Worcester, Massachusetts

    Richard C. Becker M.D. (Director) (Director)

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Christow, S.P., Gulba, D.C. (1997). Chemistry, Pharmacokinetics, and Pharmacodynamics of T-PA, TNK and DSPA Alpha 1. In: Becker, R.C. (eds) Textbook of Coronary Thrombosis and Thrombolysis. Developments in Cardiovascular Medicine, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33754-8_20

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