Plaque Disruption and Thrombosis: Models to Evaluate Acute Cardiovascular Events

  • George S. Abela
  • Joel D. Eisenberg
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


Although the concept of plaque disruption leading to arterial thrombosis is not novel, it was not accepted as a critical pathophysiologic event for many years. In fact, early publications suggested plaque disruption and thrombosis to be the mechanism underlying acute cardiovascular events [1, 2, 3, 4]. A historical report in 1912 provides an example of acute plaque disruption and thrombosis that was demonstrated by an autopsy performed immediately after sudden death [1],[5]. A subsequent report by Herrick of that event described an ulcerated atheromatous plaque extruding into the arterial lumen and a plugged coronary artery. Two decades ago, similar observations were made by DeWood et al. in patients undergoing coronary artery bypass surgery for acute myocardial infraction


Vulnerable Plaque Arterial Lumen Balloon Injury Platelet Deposition Plaque Disruption 
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© Kluwer Academic Publishers 1997

Authors and Affiliations

  • George S. Abela
  • Joel D. Eisenberg

There are no affiliations available

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