Experimental Models of Coronary Arterial Resistance and Blood Flow

  • William P. Santamore
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 193)


In this chapter, experimental preparations that have been used to examine facets of coronary artery resistance and its effects on blood flow are reviewed. Before discussing the experimental models, the characteristics of human coronary vessel - the characteristics that we are trying to model in our experimental studies - are reviewed. Also, because most clinical problems involve restriction of blood flow through the large epicardial coronary vessels, the focus is on these large coronary arteries and not on small-vessel disease models. Remember that there are no perfect experimental models; they all have shortcomings. The biggest shortcoming is using models to address questions the models were not designed to answer.


Coronary Artery Coronary Blood Flow Cold Pressor Test Arterial Stenosis Isosorbide Dinitrate 
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© Kluwer Academic Publishers 1997

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  • William P. Santamore

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