Animal Model for Retinitis Pigmentosa
N-methyl-N-nitrosourea (MNU) showed a toxic effect on the mouse and rat retinal photoreceptor cells leading to apoptosis. In agreement to human retinitis pigmentosa, the primary event was photoreceptor apoptosis. After photoreceptor cell loss, retinal pigment epithelial (RPE) cell migration to inner retina and accumulation around blood vessels were seen in humans; in rats, the migration was seen, but they were not accumulated around blood vessels, and in mice, RPE migration was not seen. In C3H mice carrying the rd gene as well as C3H mutants (Fas/Fas ligand-deficient mice), retinal degeneration occurred by an apoptotic mechanism. Therefore, Fas/Fas ligand do not play a primary role in the photoreceptor apoptosis in rd gene carrying mice.
KeywordsRetinal Pigment Epithelial Retinal Pigment Epithelial Cell Retinitis Pigmentosa Photoreceptor Cell Retinal Degeneration
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- 1.K.M. Herrold, 1976, Pigmentary degeneration of the retina induced by N-methyl-N-nitrosourea: an experimental study in Syrian hamsters, Arch. Ophthalmol. 78:650–653.Google Scholar
- 2.A.S.K. Murthy, G.F. Vawter, L. Kopito, and E. Rossen, 1972, Retinal atrophy and cataract following administration of N-methyl-N-nitrosourea, Proc. Soc. Biol. Med. 139:84–87.Google Scholar