Modification of Specific Chromosomal Loci in Mammalian Cells by Recombination

  • Paul Berg


Biochemistry and genetics epitomize what is called the reductionist approach to biology; single biological elements (for example, a protein, an enzyme, or a gene) are examined in great detail through a series of narrowly defined questions and experimental protocols. This approach can illuminate many phenotypic characteristics of complex systems, including whole organisms, if those phenotypes are the direct consequence of a single gene’s function.


Gene Conversion Homologous Integration Chromosomal Target Episomal Plasmid Specific Chromosomal Locus 
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Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • Paul Berg
    • 1
  1. 1.Beckman Center, Department of BiochemistryStanford University School of MedicineStanford

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