Modification of Specific Chromosomal Loci in Mammalian Cells by Recombination
Biochemistry and genetics epitomize what is called the reductionist approach to biology; single biological elements (for example, a protein, an enzyme, or a gene) are examined in great detail through a series of narrowly defined questions and experimental protocols. This approach can illuminate many phenotypic characteristics of complex systems, including whole organisms, if those phenotypes are the direct consequence of a single gene’s function.
KeywordsGene Conversion Homologous Integration Chromosomal Target Episomal Plasmid Specific Chromosomal Locus
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