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Modification of Specific Chromosomal Loci in Mammalian Cells by Recombination

  • Paul Berg

Abstract

Biochemistry and genetics epitomize what is called the reductionist approach to biology; single biological elements (for example, a protein, an enzyme, or a gene) are examined in great detail through a series of narrowly defined questions and experimental protocols. This approach can illuminate many phenotypic characteristics of complex systems, including whole organisms, if those phenotypes are the direct consequence of a single gene’s function.

Keywords

Gene Conversion Homologous Integration Chromosomal Target Episomal Plasmid Specific Chromosomal Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1992

Authors and Affiliations

  • Paul Berg
    • 1
  1. 1.Beckman Center, Department of BiochemistryStanford University School of MedicineStanford

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