Binding of Sucralfate to the Mucosal Surface
Much of the appeal of sucralfate as a subject of study for the experimental biologist lies in the numerous unknowns that surround its mode of action. The concept of a non-systemically acting agent that is therapeutically useful for the treatment of peptic ulcer and that works independently of effects on gastric acid secretion has its own fascination. As will become apparent, even the initial event following administration of this agent-the binding of sucralfate to the mucosa of the upper gastrointestinal tract-is not as straightforward as it might seem.
KeywordsMucosal Blood Flow Surface Epithelial Cell Mucus Glycoprotein Mucosal Secretion Acute Damage
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