Future Research into the Mechanisms of Action of Sucralfate
Sucralfate is a nonabsorbable, nonsystematic agent for the therapy and prevention of peptic ulcer disease. The drug was originally developed in Japan as an agent to deactivate peptic activity. Sucralfate was found to adhere to both ulcerated and normal mucosa with a preference for damaged areas of the gastric mucosa. 1 For these reasons, the original proposals to explain sucralfate’s therapeutic efficacy and its mechanisms of action included both pepsin antagonism and surface adhesion which presumably protect ulcerated areas from luminal acid, enzymes and exogenous damaging agents such as NSAIDs, or alcohol.
KeywordsGastric Mucosa Lamina Propria Peptic Ulcer Disease Surface Epithelium Gastrointestinal Mucosa
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