Use of Sucralfate in Variceal Sclerotherapy-Induced Ulcerations
Injection sclerotherapy of esophageal varices has become the standard therapy for patients bleeding from these lesions. Studies have shown this technique to be superior to other nonsurgical therapies and to selective shunt surgery in terms of survival and quality of life. The efficacy of this therapy, though, has been reduced by sclerotherapy-induced ulcerations. Tissue necrosis from the necrotizing chemical injected to sclerose the varices may result in deep ulceration with both arterial and venous bleeding, occasionally with perforation of the esophagus. Sucralfate has been suggested as an agent to assist in healing of these lesions, and reduce ulcer-related bleeding.
KeywordsEsophageal Varix Esophageal Mucosa Injection Sclerotherapy Esophageal Ulcer Deep Ulceration
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