Sucralfate pp 317-322 | Cite as

Sucralfate in Nonulcer Dyspepsia, Gastritis, and Duodenitis

  • M. Guslandi


Nonulcer dyspepsia (NUD) is a generic term used to describe the presence of dyspeptic symptoms in patients unaffected by pancreatic or biliary disorders (i.e., with normal abdominal ultrasound), without endoscopic signs of peptic ulcer disease or reflux esophagitis, and no symptoms clearly suggestive of irritable bowel syndrome.


Irritable Bowel Syndrome Chronic Gastritis Dyspeptic Symptom Nonulcer Dyspepsia Gastric Mucosal Blood Flow 
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  1. 1.
    Kairaluoma M, Hentilae R, Alavaikko M, et al: Sucralfate versus placebo in the treatment of nonulcer dyspepsia. Am J Med 83(suppl 3B):51–55, 1987. A major study on the use of sucralfate in dyspeptic patients with either organic or functional forms of dyspepsia.PubMedCrossRefGoogle Scholar
  2. 2.
    Barbara L, Biasco G, Capurso L, et al: Effects of sucralfate and sulglycotide treatment on active gastritis and Helicobacter pylori colonization of the gastric mucosa in non-ulcer dyspepsia patients. Am J Gastroenterol 85:1109–1113, 1990. An important study on the effects of sucralfate on histological gastritis and on the (lack of) relation to H. pylori infection.PubMedGoogle Scholar
  3. 3.
    Psilogenis M, Nazzari M, Ferrari PA: A multicenter double-blind study of sulglycotide versus sucralfate in nonulcer dyspepsia. Int J Clin Pharmacol Ther Toxicol 28:369–374, 1990. Possibly the only published study where the efficacy of sucralfate in nonulcer dyspepsia has been compared with that of an active drug.PubMedGoogle Scholar
  4. 4.
    Skoubo-Kristensen E, Funch-Jensen P, Kruse A, et al Controlled clinical trial with sucralfate in the treatment of macroscopic gastritis. Scand J Gastroenterol 24:716–720, 1989. The only example of negative results of sucralfate in the treatment of gastritis. A matter of type-2 error?PubMedCrossRefGoogle Scholar
  5. 5.
    Guslandi M: Comparison of sucralfate and ranitidine in the treatment of chronic nonerosive gastritis. A randomized, multicenter trial. Am J Med 86(suppl 6A):45–48, 1989. The largest trial on the treatment of gastritis with sucralfate and the only one directly comparing the drug with an H2-receptor antagonist as regards clinical, endoscopic, and histological results.PubMedCrossRefGoogle Scholar
  6. 6.
    Guslandi M, Ballarin E, Fanti L, et al: Follow-up of endoscopie gastritis after healing with sucralfate or an H2-receptor antagonist. Scand J Gastroenterol 27(suppl 191):25–27, 1992. Probably the first attempt to investigate the outcome of endoscopie gastritis after healing by pharmacological agents.CrossRefGoogle Scholar
  7. 7.
    Guslandi M, Molteni V, Dell’Oca M, et al: Double-blind trial of pirenzepine versus sucralfate in the treatment of endoscopie duodenitis. Clin Ther 12:26–30, 1990. The only source of information on the potential role of sucralfate in the treatment of duodenitis.PubMedGoogle Scholar
  8. 8.
    Safrany L. Schott B: Vergleich von Sucralfat und Antazida in der Behandlung der unspezifischen erosivhamorrhagischen Duodenitis. Therapiewoche 33:5233–5236, 1983. The first data, although scarce and only preliminary, on the possible use of sucralfate in erosive lesions.Google Scholar
  9. 9.
    Guslandi M, Ballarin E, Tittobello A: Rioprostil in the treatment of duodenal erosions. Scand J Gastroenterol 24(suppl 164): 174–177, 1989. The only published comparative study of sucralfate and a prostaglandin analogue in duodenal erosions.CrossRefGoogle Scholar

Copyright information

© Plenum Press 1995

Authors and Affiliations

  • M. Guslandi
    • 1
  1. 1.Gastroenterology Unit, S. Raffaele HospitalUniversity of MilanMilanItaly

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