Prevention of Respiratory Tract Infections with Sucralfate in Ventilated ICU Patients
Nosocomial infections of the respiratory tract are frequent complications in ventilated ICU patients. The reported incidences vary from 10 to 80% depending on the diagnosis, the duration of ventilation, the underlying disease, and the concomitant treatment. Nosocomial pneumonia occurs significantly more frequently in surgical ICU patients compared with medical patients.1 In surgical patients, pneumonia significantly prolongs the duration of ICU stay by about 10 days. The impact of pneumonia on mortality is conflicting. While in some studies pneumonia had no influence on mortality, other studies reported a significant increase of mortality in patients with pneumonia. Leu and co-workers2 determined that the “attributable mortality” or mortality directly related to pneumonia was 33%. Nosocomial infections significantly contributed to the morbidity and mortality of ICU patients in another study. In an analysis of more than 3000 patients who died after a traffic accident, about 25% died as a result of pneumonia, increasing to 60% in patients staying more than 28 days and being older than 70 years. Appropriate antibiotic treatment of pneumonia may improve patient survival, in one study from 36% to 72%. However, the use of broad-spectrum antibiotics in patients without infection is potentially harmful, facilitating colonization and superinfection with highly virulent organisms.
KeywordsGastric Juice Enteral Nutrition Nosocomial Pneumonia Stress Ulcer Stress Ulcer Prophylaxis
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