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Sucralfate pp 289-301 | Cite as

Sucralfate for Prevention of Acute Gastrointestinal Bleeding

  • Robert S. Bresalier

Abstract

Patients admitted to critical care units (ICUs) develop a spectrum of gastroduodenal mucosal lesions related to severe physiologic stress. Stress-related gastrointestinal bleeding from such lesions has been reported in 8 to 33% of patients admitted to ICUs who do not receive prophylactic therapy, but the incidence of severe or clinically significant bleeding is less than 6% and appears to have decreased during the past decade. Routine prophylaxis against stress-related bleeding is commonplace in ICUs worldwide, represen- ting a substantial cost to patients and use of resources. Sucralfate, primarily in suspension form, has been used extensively as prophylaxis against acute upper gastrointestinal hemorrhage in critically ill patients. This chapter will review the rationale for such therapy, and compare its efficacy with other types of treatment. Other uses of sucralfate for prevention of gastrointestinal bleeding will also be briefly discussed.

Keywords

Nosocomial Pneumonia Coffee Ground Stress Ulcer Prophylaxis Overt Bleeding Acute Gastrointestinal Bleeding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1995

Authors and Affiliations

  • Robert S. Bresalier
    • 1
  1. 1.Departments of Medicine, Henry Ford Health Sciences CenterUniversity of Michigan School of MedicineDetroit

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