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Sucralfate pp 197-207 | Cite as

Effect of Sucralfate on Experimental Ulcers

  • Susumu Okabe
  • Yoshiyasu Ogihara
  • Hiroyuki Koba

Abstract

Sucralfate is one of the best-known drugs which is frequently used for the treatment of peptic ulcers. 1,2 The mechanisms of action of sucralfate have been described in the preceding chapters. In this chapter, a detailed account will be given of the results of experimental studies of sucralfate conducted to assess its effects in preventing and heal- ing a variety of experimental ulcers induced in animals, and also of their correlation with the results of clinical use of the drug in humans.

Keywords

Ulcer Healing Stress Ulcer Gastric Mucosal Injury Gastric Mucosal Blood Flow Antiulcer Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Thomson ABR, Mahachai V: Medical management of uncomplicated peptic ulcer disease, in Berk JE (ed): Gastroenterology. Philadelphia, Saunders, 1985, p 1132–1133. A review of the medical approach to the therapy of peptic ulcer disease.Google Scholar
  2. 2.
    Hunt RH: The treatment of peptic ulcer disease with sucralfate: A review. Am J Med 91(suppl 2A):102–106, 1991. A recent review of the therapy of peptic ulcer disease with sucralfate.CrossRefGoogle Scholar
  3. 3.
    Namekata M: Studies on oxidized starch sulfates for medical purposes. IV. Protective effect of sulfates of oxidized starch and its reduced products on experimental peptic ulceration. Chem Pharm Bull 10:177–181, 1962. One of the original articles dealing with the effects of sucralfate on experimental ulcers.PubMedCrossRefGoogle Scholar
  4. 4.
    Okabe S, Takeuchi K, Kunimi H, et al: Effects of an antiulcer drug, sucralfate (a basic aluminum salt of sulfated disaccharide), on experimental gastric lesions and gastric secretion in rats. Dig Dis Sci 28:1034–1042, 1983. An article dealing with the antiulcer activity of sucralfate on various experimental ulcer models.PubMedCrossRefGoogle Scholar
  5. 5.
    Nagashima R: Development and characteristics of sucralfate. J Clin Gastroenterol 3(suppl 2):103–110, 1981. A review article about the development of sucralfate.PubMedGoogle Scholar
  6. 6.
    Auguste LJ, Shamash F, Stein TA, et al: Effect of sucralfate on the gastric mucosal levels of prostaglandin E2. Curr Surg 44:127–132, 1987. An article dealing with the effects of sucralfate on endogenous prostaglandins.PubMedGoogle Scholar
  7. 7.
    Tasman-Jones C: Gastric mucus. Physical properties in cytoprotection. Med J Aust 142(suppl):S5–S6, 1985. An article dealing with the effect of sucralfate on gastric mucus.Google Scholar
  8. 8.
    Shea-Donohue T, Steel L, Montcalm E, et al: Gastric protection by sucralfate. Role of mucus and prostaglandins. Gastroenterology 91:660–666, 1986. An article dealing with the effect of sucralfate on gastric mucus and PGs.PubMedGoogle Scholar
  9. 9.
    Konturek SJ, Brzozowski T, Majka J, et al: Nitric oxide in gastroprotection by sucralfate, mild irritants and nocloprost. Gastroenterology 102(p 2):A101, 1992. An article dealing with the mechanisms of gastroprotective action of sucralfate.Google Scholar
  10. 10.
    Ligumsky M, Karmeli F, Rachmilewitz D: Sucralfate protection against gastrointestinal damage: Possible role of prostanoids. Isr J Med Sci 22:801–806, 1986. An article dealing with the mechanisms underlying the gastroprotection of sucralfate.PubMedGoogle Scholar
  11. 11.
    Nobuhara Y, Takeuchi K, Okabe S: Effects of various agents on prednisolone-induced gastric lesions in rats. Jpn J Pharmacol 38:219–222, 1985. An article dealing with the effects of various drugs, including sucralfate, on experimental gastric ulcers induced by prednisolone.PubMedCrossRefGoogle Scholar
  12. 12.
    Morris GP, Keenan CM, MacNaughton WK, et al: Protection of rat gastric mucosa by sucralfate. Effects of luminal stasis and of inhibition of prostaglandin synthesis. Am J Med 86(suppl 6A):10–16, 1989. An article dealing with the mechanisms of gastroprotective action of sucralfate.PubMedCrossRefGoogle Scholar
  13. 13.
    Hollander D, Tarnawski A, Krause WJ, et al: Protective effect of sucralfate against alcohol-induced gastric mucosal injury in the rat. Macroscopic, histologic, ultrastructural, and functional time sequence analysis. Gastroenterology 88:366–374, 1985. An article dealing with the mechanisms of gastroprotective action of sucralfate.PubMedGoogle Scholar
  14. 14.
    Coleman JC, Lacz JP, Browne RK, et al: Effects of sucralfate or mild irritants on experimental gastritis and prostaglandin production. Am J Med 83(suppl 3B):24–30, 1987. An article dealing with the mechanism of gastroprotective action of sucralfate in relation to endogenous PGs.PubMedCrossRefGoogle Scholar
  15. 15.
    Chen BW, Hiu WM, Lam SK, et al: Effect of sucralfate on gastric mucosal blood flow in rats. Gut 30:1544–1551, 1989. An article dealing with the effect of sucralfate on gastric mucosal blood flow.PubMedCrossRefGoogle Scholar
  16. 16.
    Szabo S, Brown A: Prevention of ethanol-induced vascular injury and gastric mucosal lesions by sucralfate and its components: Possible role of endogenous sulfhydryls. Proc Soc Exp Biol Med 185:493–497, 1987. An article dealing with the gastroprotective mechanism of sucralfate in relation to endogenous sulfhydryls.PubMedGoogle Scholar
  17. 17.
    Okabe S, Ogihara Y: Effects of sucralfate on delayed healing of acetic acid-induced gastric ulcers in rats (Abstract). Jpn J Pharmacol (suppl) 49:191, 1989. An article dealing with the preventive effect of sucralfate on delayed healing of experimental gastric ulcers caused by indomethacin.Google Scholar
  18. 18.
    Konturek SJ, Brzozowski T, Drozdowicz D, et al: Role of acid milieu in the gastroprotective and ulcer-healing activity of sucralfate. Am J Med 91(suppl 2A):20–29, 1991. An article dealing with the mechanism of gastroprotective action of sucralfate.CrossRefGoogle Scholar
  19. 19.
    Kuwayama H, Matsuo Y, Eastwood GL: Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. Am J Med 91(suppl 2A):15–19, 1991. An article dealing with the mechanism of action of sucralfate on delayed healing of experimental gastric ulcers by hydrocortisone.CrossRefGoogle Scholar

Copyright information

© Plenum Press 1995

Authors and Affiliations

  • Susumu Okabe
    • 1
  • Yoshiyasu Ogihara
    • 1
  • Hiroyuki Koba
    • 2
  1. 1.Department of Applied PharmacologyKyoto Pharmaceutical UniversityKyotoJapan
  2. 2.Chugai Pharmaceutical Co., Ltd.TokyoJapan

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