Advertisement

Sucralfate pp 175-189 | Cite as

Effects of Sucralfate on Growth Factor Availability

  • Stanislaw J. Konturek
  • Jan W. Konturek
  • Tomasz Brzozowski
  • Bronislaw L. Slomiany
  • Amelia Slomiany

Abstract

The maintenance of gastric mucosal integrity under an adverse environment of luminal contents depends on the delicate balance of numerous factors that control the mucosal defense lines such as mucus-alkaline secretion, mucosal hydrophobicity, rich mucosal blood flow, maintenance of mucosal sulfhydryls, rapid restitution of epithelial cells, proliferation of mucosal cells, and tissue repair.

Keywords

Epidermal Growth Factor Gastric Mucosa Ulcer Healing Transform Growth Factor Alpha Gastric Lumen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Cohen S: Isolation of mouse submaxillary gland protein accelerating incisor eruption and eyelid opening of newborn animals. J Biol Chem 237:1155–1159, 1962. Paper providing first evidence that EGF is produced and released by salivary glands.Google Scholar
  2. 2.
    Burgess AW: Epidermal growth factor and transforming growth factor. Br Med Bull 45:410–424, 1989. Review article describing the biochemistry and physiology of EGF and TGF.Google Scholar
  3. 3.
    Konturek SJ: Role of growth factors in gastroduodenal protection and healing of peptic ulcerations. Gastroenterol Clin North Am 19:41–65, 1990. Review article describing the distribution and protective and healing effects of EGF on the gastric and duodenal mucosa.PubMedGoogle Scholar
  4. 4.
    Konturek JW, Brzozowski T, Konturek SJ: Epidermal growth factor in protection, repair and healing of gastroduodenal mucosa. J Clin Gastroenterol 13(suppl 1):S88–S97, 1991. Review of the gastroprotective and ulcer healing actions of EGF with emphasis on the involvement of polyamines and prostaglandins in this actions.PubMedCrossRefGoogle Scholar
  5. 5.
    Wright NA, Pike C, Elia G: Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 343:82–85, 1990. Paper demonstrating that EGF-producing cells may proliferate from the stem cells in the ulcer area to stimulate locally the repair and healing process.PubMedCrossRefGoogle Scholar
  6. 6.
    Polk WH, Dempsey PJ, Russell WE, et al: Increased production of transforming growth factor alpha following acute gastric injury. Gastroenterology 102:1462–1474, 1992. Paper providing evidence that the mucosal damage results in an increase in TGFα mRNA expression and TGFα release suggesting that this growth factor participates in gastric mucosal repair following acute gastric injury. EGF mRNA expression was not detected and little EGF was found, indicating that this growth factor does not originate from the intact or injured gastric mucosa.Google Scholar
  7. 7.
    Folkman J, Szabo S, Stovroff M, et al: Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann Surg 214:414–425, 1991. The proposal of a model for ulcer healing by conventional therapy involving bFGF as the major factor in angiogenesis and healing of gastroduodenal ulcers.PubMedCrossRefGoogle Scholar
  8. 8.
    Slomiany BL, Liu J, Yao P, et al: Characterization of the epidermal growth factor receptor in the gastric mucosa. Digestion 47:181–190, 1990. Paper demonstrating the existence and binding characteristics of high-affinity receptor for EGF in the membranes of the gastric mucosa.PubMedCrossRefGoogle Scholar
  9. 9.
    Tarnawski A, Erickson RA: Sucralfate—24 years later: Current concepts of its protective and therapeutic actions. Eur J Gastroenterol Hepatol 3:795–810, 1991. A comprehensive overview of the basic and clinical research related to the gastroprotective and ulcer healing action of sucralfate and the concepts of the mechanisms of action of this drug on the gastric mucosa.Google Scholar

Copyright information

© Plenum Press 1995

Authors and Affiliations

  • Stanislaw J. Konturek
    • 1
  • Jan W. Konturek
    • 1
  • Tomasz Brzozowski
    • 1
  • Bronislaw L. Slomiany
    • 2
  • Amelia Slomiany
    • 2
  1. 1.Institute of PhysiologyUniversity School of MedicineKrakowPoland
  2. 2.Research CenterUniversity of Medicine and DentistryNewark

Personalised recommendations