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Sucralfate pp 151-162 | Cite as

Vascular Factors

Mucosal Vasoprotection and Angiogenesis
  • Zsuzsa Sandor
  • Sandor Szabo

Abstract

Vascular factors refer to acute endothelial damage and protection, regulation of blood flow, and generation of new blood vessels (angiogenesis). The investigation of vascular factors is a relatively new subject in ulcer research. 15 Historically, most of the experimental work on the stomach was related to the structure and function of epithelial cells (e.g., gastric secretion) (Table 1). This was in part the result of conceptual focus on epithelial cells and availability of methods. Subsequently, blood flow was investigated per se in relation to gastric secretion, mucosal injury, and ulcer localization in the stomach and duodenum. If ischemia was considered, it was ascribed to external or internal (e.g., thrombosis) narrowing and not to active involvement of endothelial cells (e.g., in regulating vascular permeability).

Keywords

Vascular Injury Granulation Tissue Ulcer Healing Mucosal Blood Flow Gastric Mucosal Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1995

Authors and Affiliations

  • Zsuzsa Sandor
    • 1
  • Sandor Szabo
    • 1
  1. 1.Chemical Pathology Research Division, Department of PathologyBrigham & Women’s Hospital, and Harvard Medical SchoolBoston

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