Sucralfate pp 141-149 | Cite as

Sucralfate and Cell Proliferation

  • Hajime Kuwayama


The gastroduodenal epithelium is one of the most rapidly proliferating tissues in the body. The surface epithelial cells of the gastroduodenum are renewed every 2–3 days in rodents and 4–5 days in humans. 1 Why is there such rapid renewal? Possibly because mucosae of the stomach and duodenum are always exposed to irritants, including not only exogenous agents such as seasonings/spicy food, alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs) but also physiological substances such as hydrochloric acid, pepsin, and bile acids. In addition, motor activity facilitates exfoliation of epithelial cells. Exfoliated cells are then promptly replaced with new cells. It seems to be the physiological destiny of epithelium of the gastroduodenum to be constantly damaged, exfoliated, and renewed.


Epidermal Growth Factor Receptor Proliferate Cell Nuclear Antigen Basic Fibroblast Growth Factor Epithelial Proliferation Surface Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Eastwood GL: Gastrointestinal epithelial renewal. Gastroenterology 72:962–965, 1977. Comprehensive review of gastrointestinal epithelial renewal, which also covers basic methods and concept of epithelial renewal. Excellent for those who are interested in epithelial renewal.PubMedGoogle Scholar
  2. 2.
    Lacy E: Epithelial restitution in the gastrointestinal tract. J Clin Gastroenterol 10(suppl 1):S72–S77, 1988. Rapid restitution after superficial injury, which is originally found in the gastric mucosa, is a phenomenon occurring throughout the gastrointestinal mucosa including esophagus.PubMedCrossRefGoogle Scholar
  3. 3.
    Kuwayama H, Matsuo Y, Eastwood G: Gastroduodenal mucosal injury by nonsteroidal antiinflammatory drugs. Drug Invest 2(suppl 1):22–26, 1990. Brief review of gastroduodenal mucosal injury by nonsteroidal antiinflammatory drugs with special reference to effects on epithelial renewal.Google Scholar
  4. 4.
    Barnes D: Growth factors involved in repair processes: An overview. Methods Enzymol 163:707–715, 1988. Detailed review including methodology of growth factors in tissue repair. These are many growth factors that may stimulate or inhibit tissue repair process.PubMedCrossRefGoogle Scholar
  5. 5.
    Luk GD: Polyamines in intestinal growth. Biochem Soc Trans 18:1090–1091, 1990. An updated brief review of role of polyamines in intestinal growth. Readers can find the significance of polyamines in cellular growth as well as differentiation.PubMedGoogle Scholar
  6. 6.
    Eastwood G: Epithelial renewal in protection and repair of gastroduodenal mucosa. J Clin Gastroenterol 13:S48–S53, 1991. This review summarizes changes in epithelial renewal of the gastroduodenal mucosa in response to different conditions or mucosal damaging agents.PubMedCrossRefGoogle Scholar
  7. 7.
    Yeomans N: Repair and healing of established gastric mucosal injury. J Clin Gastroenterol 13(suppl 1):S37–S41, 1991. A good review of the morphological process during repair of the gastric mucosa.PubMedCrossRefGoogle Scholar
  8. 8.
    Folkman J, Szabo S, Stovroff M, et al: Duodenal ulcer. Discovery of a new mechanism and development of angiogenetic therapy that accelerates healing. Ann Surg 214:414–425, 1991. This review introduces mechanism of healing ulcers focusing on FGF which can be achieved by either suppression of gastric acid secretion or sucralfate binding to FGF.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press 1995

Authors and Affiliations

  • Hajime Kuwayama
    • 1
    • 2
  1. 1.Department of MedicineNihon University School of MedicineTokyo
  2. 2.University of Texas Southwestern MedicalSchoolDallas

Personalised recommendations