The gastroduodenal epithelium is one of the most rapidly proliferating tissues in the body. The surface epithelial cells of the gastroduodenum are renewed every 2–3 days in rodents and 4–5 days in humans. 1 Why is there such rapid renewal? Possibly because mucosae of the stomach and duodenum are always exposed to irritants, including not only exogenous agents such as seasonings/spicy food, alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs) but also physiological substances such as hydrochloric acid, pepsin, and bile acids. In addition, motor activity facilitates exfoliation of epithelial cells. Exfoliated cells are then promptly replaced with new cells. It seems to be the physiological destiny of epithelium of the gastroduodenum to be constantly damaged, exfoliated, and renewed.
KeywordsEpidermal Growth Factor Receptor Proliferate Cell Nuclear Antigen Basic Fibroblast Growth Factor Epithelial Proliferation Surface Epithelial Cell
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