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Sucralfate pp 127-132 | Cite as

Stimulation of Mucosal Prostaglandins by Sucralfate

  • Daniel Rachmilewitz

Abstract

Sucralfate enhances ulcer healing and protects the mucosa of the stomach against damage induced by various irritants in human subjects as well as in experimental animals. Since sucralfate does not affect gastric acid secretion, other mechanisms are responsible for its protective and healing effects. Sucralfate’s efficacy in the prevention of gastric mucosal injury induced by various irritants mimics to some extent the protection afforded by prostaglandins. The hypothesis that sucralfate enhances mucosal defense and induces ulcer healing via stimulation of endogenous gastric prostaglandin synthesis was therefore thoroughly investigated in experimental models and also in human subjects. Whereas in many studies the direct effect of sucralfate on gastric generation and release of prostaglan- dins was evaluated, another approach elucidated the effect of cyclooxygenase inhibitors such as indomethacin on the protection afforded by sucralfate.

Keywords

Peptic Ulcer Disease Gastric Acid Secretion Gastric Damage Gastric Mucosal Injury Gastric Mucosal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1995

Authors and Affiliations

  • Daniel Rachmilewitz
    • 1
  1. 1.Department of Medicine, Hadassah University HospitalMount Scopus, Hebrew University Hadassah Medical SchoolJerusalemIsrael

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