Effect of Sucrose Octasulfate on Isolated Gastric Cells
Sucralfate, which is an aluminum salt of the sulfated disaccharide sucrose octasulfate, has been shown to promote healing of experimental gastric ulcers in rats and duodenal ulcers in humans. 1 Sucralfate has been approved by the Food and Drug Administration as therapy for duodenal ulcers, both for healing and as prophylaxis against recurrence. The mechanisms whereby sucralfate exerts its salutary effects on gastric and duodenal mucosa are insufficiently understood. In 1991, McCarthy listed the possible actions of sucralfate to include antipeptic effects, cytoprotective effects, actions on arachidonic acid metabolites, mucus, and bicarbonate, and finally effects on tissue growth, regeneration, and repair. 1 However, he did not consider whether sucralfate or sucrose octasulfate, its presumed active constituent, could either promote ulcer healing or prevent ulcer recurrence by influencing the secretion by the stomach of either acid or regulatory peptides.
KeywordsDuodenal Ulcer Dibutyryl cAMP Gastric Parietal Cell Experimental Gastric Ulcer Single Cell Preparation
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