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Sucralfate pp 103-109 | Cite as

Effect of Sucrose Octasulfate on Isolated Gastric Cells

  • Michael R. Lucey
  • Tadataka Yamada

Abstract

Sucralfate, which is an aluminum salt of the sulfated disaccharide sucrose octasulfate, has been shown to promote healing of experimental gastric ulcers in rats and duodenal ulcers in humans. 1 Sucralfate has been approved by the Food and Drug Administration as therapy for duodenal ulcers, both for healing and as prophylaxis against recurrence. The mechanisms whereby sucralfate exerts its salutary effects on gastric and duodenal mucosa are insufficiently understood. In 1991, McCarthy listed the possible actions of sucralfate to include antipeptic effects, cytoprotective effects, actions on arachidonic acid metabolites, mucus, and bicarbonate, and finally effects on tissue growth, regeneration, and repair. 1 However, he did not consider whether sucralfate or sucrose octasulfate, its presumed active constituent, could either promote ulcer healing or prevent ulcer recurrence by influencing the secretion by the stomach of either acid or regulatory peptides.

Keywords

Duodenal Ulcer Dibutyryl cAMP Gastric Parietal Cell Experimental Gastric Ulcer Single Cell Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McCarthy DM: Sucralfate. N Engl J Med 325:1017–1025, 1991. An excellent overview of sucralfate, its potential mechanisms of action, and uses in gastrointestinal disorders.PubMedCrossRefGoogle Scholar
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    Lucey MR, Yamada T: Biochemistry and physiology of gastrointestinal somatostatin. Dig Dis Sci 34(3):5S–13S, 1989. A review of the role of somatostatin in the gastrointestinal tract.PubMedCrossRefGoogle Scholar
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    Zierend H, Hengst K, Wagner H, et al: Inhibition of stress ulcer formation with somatostatin in rats. Res Exp Med 168:199–204, 1976. In vivo study showing that somatostatin may modulate the formation of experimentally induced gastric ulcers.CrossRefGoogle Scholar
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    Lucey MR, Park J, Del Valle J, et al: Sucrose octasulphate stimulates gastric somatostatin release. Am J Med 91(suppl 2A):52S–58S, 1991.PubMedCrossRefGoogle Scholar
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    Yamada T, Soll AH, Park J, et al: Autonomic regulation of somatostatin release: Studies with primary cultures of canine fundic mucosal cells. Am J Physiol 247:G567–G573, 1984. One of a number of papers in which the cell separation and culture methods used herein are described. Reference 4 includes a more comprehensive list of references.PubMedGoogle Scholar
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    Lucey MR, Wass JAH, Rees LH, et al: Relationship between gastric acid and elevated plasma somatostatin-like immunoreactivity after a mixed meal. Gastroenterology 97:867–872, 1989. Astudy in humans showing that luminal factors such as gastric acid influence release of somatostatin.PubMedGoogle Scholar

Copyright information

© Plenum Press 1995

Authors and Affiliations

  • Michael R. Lucey
    • 1
  • Tadataka Yamada
    • 1
  1. 1.Department of Internal MedicineUniversity of Michigan Medical CenterAnn Arbor

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