Abstract
B lymphocytes are continuously generated throughout life. Like all other members of the hematopoietic system, B cells are derived from multipotent hematopoietic stem cells (Wu et al., 1967). The developmental pathway that leads from multipotent stem cells to committed B lymphocytes is characterized by a series of differentiation steps. Many of these steps can be recognized based on the appearance of proteins such as growth factor receptors or the B-lineage-specific molecules that allow or promote the further development of progenitor cells. These stages of differentiation can also be recognized based on functional assays that have been developed over the last 30 years. Initially, such assay systems relied on the ability of progenitor cells to repopulate the hematopoietic system of a mouse that had previously been subjected to high doses of ionizing radiation. This approach has been crucial for the identification of multipotent stem cells and defining cells, which have long-term reconstituting potential (Dick et al., 1985; Keller et al.,1985; Lemischka et al., 1986). Irradiation/reconstitution experiments have been less useful for identifying intermediate stages in the developmental process. This method is also inadequate for studying either the essential cellular interactions or the growth and differentiation factors that promote hematopoiesis.
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Cumano, A., Kee, B.L., Godin, I., Dieterlen-Lièvre, F., Paige, C.J. (1996). Hematopoietic Growth Factors Involved in B-Cell Development. In: Whetton, A.D., Gordon, J. (eds) Blood Cell Biochemistry. Blood Cell Biochemistry, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-31728-1_9
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