Abstract
The number of cells in any tissue is dependent on the balance between cell gain by proliferation and cell loss by differentiation and/or cell death (Figure 1). The importance of this balancing act is demonstrated particularly well within the hematopoietic system, where it is thought that in the order of billions of cells are produced every day to replace cell loss. Thus, it is reasonable to suggest that defects in this cell-gain—cell-loss balance are likely to contribute to a number of pathologies of the blood. Enhanced survival, restricted differentiation, and uncontrolled proliferation together conspire to promote the development of lymphomas and leukemias.
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Chapman, R.S., Gregory, C.D., Dive, C. (1996). Apoptosis in Hematopoiesis and Leukemogenesis. In: Whetton, A.D., Gordon, J. (eds) Blood Cell Biochemistry. Blood Cell Biochemistry, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-31728-1_7
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