Myelosuppressive Cytokines and Peptides

  • Hal E. Broxmeyer
Part of the Blood Cell Biochemistry book series (BLBI, volume 7)


The mature blood cells that fight infection and disease (neutrophilic granulocytes, monocytes/macrophages, lymphocytes, natural killer cells), allow us to breathe (erythrocytes), and prevent us from bleeding to death (platelets), which are thus imperative for maintenance of our health, are produced by hematopoietic stem and progenitor cells (Broxmeyer and Williams, 1988; Broxmeyer, 1992a, 1993). Regulation of blood cell production involves an interacting network of cytokine—cell interactions. Over 50 different cytokines have been identified that can influence blood cell production, at least in vitro (Broxmeyer and Williams, 1988; Broxmeyer, 1992a, 1993,1995a, 1996). This regulation can occur by stimulation, enhancement (augmentation), and/or suppression of the growth and differentiation of hematopoietic stem and progenitor cells. Hematopoietically active cytokines include the colony-stimulating factors (CSF) granulocyte (G)-CSF, macrophage (M)-CSF, GM-CSF, interleukin (IL-3), IL-5, and erythropoietin (Epo), and other interleukins, presently numbering 1 to 17. Non-CSF interleukins include potent costimulating cytokines: steel factor (SLF, or stem cell factor), and flt3/flk2 ligand (L), involved in synergistic stimulation of cell proliferation (Broxmeyer, 1992a,b, 1993, 1995a; Broxmeyer et al.,1991b, 1995a).


Progenitor Cell Transform Growth Factor Macrophage Inflammatory Protein Vascular Endothelial Cell Growth Factor Human Lactoferrin 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Hal E. Broxmeyer
    • 1
  1. 1.Departments of Medicine and Microbiology/Immunology and Walther Oncology CenterIndiana University School of MedicineIndianapolisUSA

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