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The Role of Interleukin 5 in the Production and Function of Eosinophils

  • Jan Tavernier
  • Geert Plaetinck
  • Yves Guisez
  • Jose van der Heyden
  • Johan Kips
  • Renaat Peleman
  • Rene Devos
Part of the Blood Cell Biochemistry book series (BLBI, volume 7)

Abstract

The development of the different lineages of the hematopoietic system is regulated by a set of intercellular interactions, either by direct cellular contact or via the release of soluble factors. Proliferation, self-renewal, and lineage commitment are all strongly influenced by a complex network of external factors. Among these, cytokines play a crucial role. Both constitutive and inducible hematopoiesis are regulated by cytokines, which in the former case are secreted by stromal cells within the bone-marrow microenvironment and in the latter case reach the bone marrow via the blood circulation after being produced in inflamed tissues. Many of these cytokines influence each other’s pattern of activities in a synergistic or antagonistic way. In addition, some cytokines have a (lineage-) restricted biological repertoire, and others exert a broad spectrum of activities (“pleiotropy”), resulting in functional overlaps (“redundancy”) within this complex signaling network.

Keywords

Tyrosine Phosphorylation Bronchial Hyperresponsiveness Human Eosinophil Major Basic Protein Idiopathic Hypereosinophilic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Jan Tavernier
    • 1
  • Geert Plaetinck
    • 1
  • Yves Guisez
    • 1
  • Jose van der Heyden
    • 1
  • Johan Kips
    • 2
  • Renaat Peleman
    • 2
  • Rene Devos
    • 1
  1. 1.Roche Research GentGentBelgium
  2. 2.Department of Respiratory DiseasesUniversity Hospital, DepintelaanGentBelgium

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