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The Role of Interleukin 5 in the Production and Function of Eosinophils

  • Chapter
Blood Cell Biochemistry

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 7))

Abstract

The development of the different lineages of the hematopoietic system is regulated by a set of intercellular interactions, either by direct cellular contact or via the release of soluble factors. Proliferation, self-renewal, and lineage commitment are all strongly influenced by a complex network of external factors. Among these, cytokines play a crucial role. Both constitutive and inducible hematopoiesis are regulated by cytokines, which in the former case are secreted by stromal cells within the bone-marrow microenvironment and in the latter case reach the bone marrow via the blood circulation after being produced in inflamed tissues. Many of these cytokines influence each other’s pattern of activities in a synergistic or antagonistic way. In addition, some cytokines have a (lineage-) restricted biological repertoire, and others exert a broad spectrum of activities (“pleiotropy”), resulting in functional overlaps (“redundancy”) within this complex signaling network.

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Authors and Affiliations

  1. Roche Research Gent, 9000, Gent, Belgium

    Jan Tavernier, Geert Plaetinck, Yves Guisez, Jose van der Heyden & Rene Devos

  2. Department of Respiratory Diseases, University Hospital, Depintelaan, 9000, Gent, Belgium

    Johan Kips & Renaat Peleman

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  1. Jan Tavernier
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  1. Leukaemia Research Fund Cellular Development Unit, UMIST, Manchester, England

    Anthony D. Whetton

  2. The Medical School, University of Birmingham, Birmingham, England

    John Gordon

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Tavernier, J. et al. (1996). The Role of Interleukin 5 in the Production and Function of Eosinophils. In: Whetton, A.D., Gordon, J. (eds) Blood Cell Biochemistry. Blood Cell Biochemistry, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-31728-1_13

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