Responses of Leukemia Cells to Hematopoietic Growth Factors

Involvement of Autocrine Growth Mechanisms, Cytogenetic Abnormalities, and Defective Maturation Signaling
  • Ivo P. Touw
  • Fan Dong
Part of the Blood Cell Biochemistry book series (BLBI, volume 7)


All blood cells produced throughout life descend from a small number of pluripotent hematopoietic stem cells, which, in adult man, reside predominantly in the bone marrow. The pluripotent stem cells generate progenitor cells committed to proliferate and mature toward the different functional end cells. The mature blood cells have a limited life span and need to be produced continuously. The hematopoietic system adapts in a highly dynamic fashion to changes in the requirements for different blood cells, for instance, during stages of infection or following sudden loss of blood. The rapid and variable needs for the various blood cell types demand a tight and complex control mechanism that finely regulates renewal, commitment, proliferation, maturation, and survival of hematopoietic cells. The hematopoietic growth factors (HGFs) play a central role in these processes (Clark and Kamen, 1987; Metcalf, 1989).


Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Acute Promyelocytic Leukemia Stem Cell Factor Acute Myeloid Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ivo P. Touw
    • 1
  • Fan Dong
    • 1
  1. 1.Department of HematologyDr. Daniel den Hoed Cancer Center and Erasmus UniversityRotterdamThe Netherlands

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