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Regulation of Peripheral B-Cell Growth and Differentiation

  • Jacques Banchereau
  • Pierre Garrone
  • Yong-Jun Liu
Part of the Blood Cell Biochemistry book series (BLBI, volume 7)

Abstract

The life histories of B lymphocytes and T lymphocytes share many similar features. They derive from immature precursor cells and use similar genes and strategy to encode, assemble, and select their surface antigen receptors. T-cell development in the thymus involves a series of stringent positive and negative selection processes that ensure (1) that the generated T-cell receptors distinguish self and nonself antigen and (2) the dependence on the recognition of self-MHC to respond to nonself antigens. B-cell development within the bone marrow also involves a series of selection processes that ensure that the generated B-cell antigen receptors directly recognize nonself antigen without the involvement of selfMHC. The current views of primary T-cell and B-cell lymphopoiesis in the thymus and bone marrow, respectively, are generated by two considerations: (1) each stage of gene rearrangement and the selection of the host cells correspond to a particular stage of cellular differentiation characterized by surface molecules that collectively define a cell subset; (2) a particular differentiation stage/cell subset is localized within a particular anatomic compartment of the thymus or bone marrow. Thus, the whole differentiation pathway seems to follow a specific migration pattern through different functional compartments of thymus or bone marrow, where they interact with different stromal cells/accessory cells. These two experimental approaches, together with gene cloning, should ultimately permit the isolation of the regulatory molecules that drive the cells from one differentiation stage to the next during the primary B-cell and T-cell developments.

Keywords

Plasma Cell Somatic Mutation Germinal Center Antigen Receptor Follicular Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Jacques Banchereau
    • 1
  • Pierre Garrone
    • 1
  • Yong-Jun Liu
    • 1
  1. 1.Schering-PloughLaboratory for Immunological ResearchDardillyFrance

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