Skip to main content
SpringerLink
Log in
Book cover

Blood Cell Biochemistry pp 1–40Cite as

The Hematopoietic Cytokine Receptors

  • Chapter

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 7))

Abstract

The growth and differentiation of hematopoietic stem cells to form the vast repertoire of mature blood cells that exists in vivo is orchestrated by an array of intercellular signals, mediated by cytokines in association with a complex stromal microenvironment. Cytokines are a diverse group of glycoproteins, expressed constitutively or inducibly by a wide variety of cell types, in membrane-bound or secreted forms (reviewed in Nicola, 1989; Arai et al., 1990; Howard et al., 1993). In addition to controlling hematopoietic development, cytokines mediate many physiological responses, such as immunity, inflammation, and antiviral activity. A single cytokine can exhibit multiple functions depending on its target cell type, and different cytokines often show similar biological functions on the same target cell population (Metcalf, 1986). Combinations of cytokines can interact synergistically (Metcalf and Nicola, 1991; Heyworth et al., 1988, 1992) or antagonistically (reviewed in Graham and Pragnell,1990; Ruscetti et al.,1991) to give novel responses. In addition, many cytokines trigger the release of other cytokines (Dinarello et al., 1986; Fibbe et al., 1986; Yang et al.,1988). Thus, a complex network is formed among various types of cells through cytokines.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aguet, M., and Mogensen, K. E., 1983, Interferon receptors, Interferon 5: 1–22.

    CAS  PubMed  Google Scholar 

  • Aguet, M., Dembic, Z., and Merlin G., 1988, Molecular cloning and expression of the human interferon-gamma receptor, Cell 55: 273–280.

    CAS  PubMed  Google Scholar 

  • Anderson, K. C., Morimoto, C., Paul, S. R., Chauhan, D., Williams, D., Cochran, M., and Barut, B. A., 1992, Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans, Res. Immunol. 143: 385–400.

    Google Scholar 

  • Andres, J. L., Stanley, K., Cheifetz, S., and Massague, J., 1989, Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-p, J. Cell. Biol. 109: 31373145.

    Google Scholar 

  • Arai, K., Lee, F., Miyajima, A., Miyatake, S., Arai, N., and Yokota, T., 1990, Cytokines: Coordinators of immune and inflammatory responses, Annu. Rev. Biochem. 59: 783–836.

    CAS  PubMed  Google Scholar 

  • Artgetsinger, L. S., Campbell, G. S., Yang, X., Witthuhn, B. A., Silvennoinen, O., Ihle, J. N., and Carter Su, C., 1993, Identification of Jak2 as a growth hormone receptor-associated tyrosine kinase, Cell 74: 237–244.

    Google Scholar 

  • Banchereau, J., Bazan, F., Blanchard, D., Briere, F., Galizzi, J P., Van, K. C., Liu, Y. J., Rousett, F., and Saeland, S., 1994, The CD40 antigen and its ligand. Annu. Rev. Immunol. 12: 881–922.

    CAS  PubMed  Google Scholar 

  • Banner, D. W., D’Arcy, A., Janes, W., Gentz, R., Schoenfeld, H. J., Broger, C., Loetscher, H., and Lesslauer, W., 1993, Crystal structure of the soluble human 55kd TNF receptor—human TNF-beta complex: Implications for TNF receptor activation. Cell 73: 431–445.

    CAS  PubMed  Google Scholar 

  • Barton, D. P., Blanchard, D. K., Michelini, N. B., Nicosia, S. V., Cavanagh, D., and Djeu, J. Y., 1993, High serum and ascitic soluble interleukin-2 receptor alpha levels in advanced epithelial ovarian cancer, Blood 81: 424–429.

    CAS  PubMed  Google Scholar 

  • Bassing, C. H., Howe, D. J., Segarini, P. R., Donahoe, P. K., and Wang, X. F., 1994a, A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands, J. Biol. Chem. 269: 14861–14864.

    CAS  PubMed  Google Scholar 

  • Bassing, C. H., Yingling, J. M., Howe, D. J., Wang, T., He, W. W., Gustafson, M. L., Shah, P., Donahoe, P. K., and Wang, X. F., 1994b, A transforming growth factor beta type I receptor that signals to activate gene expression, Science 263: 87–89.

    CAS  PubMed  Google Scholar 

  • Baumann, H., Marinkovic-Pajovic, S., Won, K.-A., Jones, E. V., Campos, S. P., Jahreis, G. P., and Morella, K. K., 1992, The action of interleukin-6 and leukaemia inhibitory factor on liver cells, in Polyfunctional Cytokines: IL-6 and LIF (G. R. Bock, J. Marsh, and K. Widdows, eds.), pp. 100–124, Wiley, Chicester.

    Google Scholar 

  • Baumann, H., Symes, A. J., Comeau, M. R., Morella, K. K., Wang, Y., Friend, D., Zielger, S. F., Fink, J. S., and Gearing, D. P., 1994a, Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells, Mol. Cell. Biol. 14: 138–146.

    CAS  PubMed  Google Scholar 

  • Baumann, H., Gearing, D., and Zielger, S. F., 1994b, Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells, J. Biol. Chem. 269: 16297–16304.

    CAS  PubMed  Google Scholar 

  • Bazan, J.F., 1989, A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin, and IL-6 receptors, and the p75 IL-2 receptor 13 chain, Biochem. Biophys. Res. Commun. 164: 788–795.

    CAS  PubMed  Google Scholar 

  • Bazan, J. F., 1990, Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 87: 6934–6938.

    CAS  PubMed  Google Scholar 

  • Bazan, F., 1993, Emerging families of cytokine and receptors. Curr. Biol. 3: 603–606.

    CAS  PubMed  Google Scholar 

  • Boulton, T. G., Stahl, N., and Yancopoulos, G. D., 1991, Ciliary neurotrophic factor/leukemia inhibitory factor/ interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors, Science 253: 59–63.

    Google Scholar 

  • Boutin, J.-M., Jolicoeur, C., Okamura, H., Gagnon, J., Edery, M., Shiroota, M., Banville, D., Dusanter-Fourt, I., Djiane, J., and Kelly, P.A., 1988, Cloning and expression of the rat prolactin receptor, a member of the growth factor hormone/prolactin receptor gene family, Cell 53: 69–77.

    CAS  PubMed  Google Scholar 

  • Branca, A. A., and Baglioni, C., 1981, Evidence that types I and II interferons have different receptors, Nature 294: 768–770.

    CAS  PubMed  Google Scholar 

  • Breen, F. N., Hume, D. A., and Weidemann, M. J., 1993, The effects of interleukin 3 (IL-3) on cells responsive to macrophage colony-stimulating factor (CSF-1) in liquid murine bone marrow culture, Blood 82: 752–761.

    Google Scholar 

  • Bruce, A. G., Hoggatt, I. H., and Rose, T. M., 1994, Oncostatin M is a differentiation factor for myeloid leukemia cells, Cytokine 6: 48–54.

    PubMed  Google Scholar 

  • Cannistra, S. A., Vellenga, E., Groshek, P., Rambaldi, A., and Griffin, J. D., 1988, Human granulocyte-macrophage colony-stimulating factor and interleukin-3 stimulate monocyte cytotoxicity through a tumour necrosis factor-dependent mechanism, Blood 71: 672–676.

    CAS  PubMed  Google Scholar 

  • Chabot, B., Stephenson, D. A., Chapman, V. M., Besme, R. P., and Berstein, A., 1988, the proto-oncogene ci-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus, Nature 335: 88–89.

    Google Scholar 

  • Chang, M. S., Engel, G., Benedict, C., Basu, R., and McNinch, J., 1994, Isolation and characterization of the human interleukin-9 receptor gene, Blood 83: 3199–3205.

    CAS  PubMed  Google Scholar 

  • Chen, R. H., Ebner, R., and Derynck, R., 1994, Inactivation of the type II receptor receals two receptor pathways for the diverse TFG-beta activities, Science 260: 1335–1338.

    Google Scholar 

  • Chua, A. O., Chizzonite, R., Desai, R., Truitt, T. P., Nunes, P., Minetti, L. J., Warner, R. R., Presky, D. H., Levine, J. F., Gately, M. K., and Gubler, U., 1994, Expression cloning of a human IL-12 receptor component, J. Immunol. 153: 128–136.

    CAS  PubMed  Google Scholar 

  • Colotta, F., Bussolino, F., Polentarutti, N., Guglielmetti, A., Sironi, M., Bocchietto, E., De, R.M., and Mantovani, A., 1991, Differential expression of the common beta and specific alpha chains of the receptors for GM-CSF, IL-3, and IL-5 in endothelial cells. Virology 180: 633–647.

    Google Scholar 

  • Conlon, P. J., Morrissey, P. J., Nordan, R. P., Grabstein, K. H., Prickett, K. S., Reed, S. G., Goodwin, R., Cosman, D., and Namen, A. E., 1989, Murine thymocytes proliferate in direct response to interleukin 7, Blood 74: 1368–1373.

    CAS  PubMed  Google Scholar 

  • Cosman, D., 1993, The hematopoietin receptor superfamily, Cytokine 5: 95–106.

    CAS  PubMed  Google Scholar 

  • D’Andrea, A. D., Fasman, G. D., and Lodish, H. F., 1989a, Erythropoietin receptor and interleukin-2 receptor beta chain: a new receptor family, Cell 57: 277–285.

    PubMed  Google Scholar 

  • D’ Andrea, A. D., Lodish, H. F., and Wong, G. G., 1989b, Expression cloning of the murine erythropoietin receptor, Cell 57: 277–285.

    Google Scholar 

  • Darnell, J. J., Kerr, I. M., and Stark, G. R., 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science 264: 1415–1421.

    CAS  PubMed  Google Scholar 

  • Davis, S., Aldrich, T. H., Valenzuela, D. M., Furth, M. E., Squinto, S. P., and Yancopoulos, G. D., 1991, The receptor for ciliary neurotrophilic factor, Science 253: 59–63.

    CAS  PubMed  Google Scholar 

  • Davis, S., Aldrich, T. H., Stahl, N., Pan, L., Taga, T., Kishimoto, T., Ip, N. Y., and Yancopoulos, G. D., 1993, LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor, Blood 82: 1120–1126.

    Google Scholar 

  • de la Chapelle, A., Traskelin, A. L., and Juvonen, E., 1993, Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis, Proc. Natl. Acad. Sci. U.S.A. 90: 4495–4499.

    CAS  PubMed  Google Scholar 

  • De Vos, A. M., Ultsch, M., and Kossiakoff, A. A., 1992, Human growth hormone and the extracellular domain of its receptor: Crystal structure of the complex, Science 225: 306–312.

    Google Scholar 

  • Dinarello, C. A., Canin, A. J. C., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Palladino, M. A., Jr., and O’Connor, J. V., 1986, Tumour necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin-1 (IL-1), J. Exp. Med. 163: 1433–1450.

    CAS  PubMed  Google Scholar 

  • Druez, C., Coulie, P., Uyttenhove, C., and Van Snick, J., 1990, Functional and biochemical characterization of mouse p40/IL-9 receptors, J. Immunol. 145: 2494–2499.

    CAS  PubMed  Google Scholar 

  • Duronio, V., Welham, M. J., Abraham, S., Dryden, P., and Schrader, J. W., 1992, p2lras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p2lras GTPaseactivating protein, Proc. Natl. Acad. Sci. U.S.A. 89: 1587–1591.

    Google Scholar 

  • Dusanter, F. I., Muller, O., Ziemiecki, A., Mayeux, P., Drucker, B., Djiane, J., Wilks, A., Harpur, A. G., Fischer, S., and Gisselbrecht, S., 1994, Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lympoid cells, EMBO J. 13: 2583–2591.

    Google Scholar 

  • Fanslow, W. C., Clifford, K. N., Park, L. S., Rubin, A. S., Voice, R. F., Beckmann, M. P., and Widmer, M. B., 1991, Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor, J. Immunol. 147: 535–540.

    CAS  PubMed  Google Scholar 

  • Farrar, M. A., Campbell, J. D., and Schreiber, R. D., 1992, Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor, Proc. Natl. Acad. Sci. U.S.A. 89: 11706–11710.

    CAS  PubMed  Google Scholar 

  • Feldman, G. M., Petricoin, E. E 3rd, David, M., Larner, A. C., and Finbloom, D. S., 1994, Cytokines that associate with the signal transducer gp130 activate the interferon-induced transcription factor p91 by tyrosine phosphorylation, J. Biol. Chem. 269: 10747–10752.

    CAS  PubMed  Google Scholar 

  • Fibbe, W. E., van, D. J., Billiau, A., Voogt, P. J., Duinkerken, N., Kluck, P. M., and Falkenburg, J. H., 1986, Interleukin-1 (22-K factor) induces release of granulocyte-macrophage colony-stimulating activity from human mononuclear phagocytes, Blood 68: 1316–1321.

    CAS  PubMed  Google Scholar 

  • Fischer, T., Rehm, A., Aguet, M., and Pfizenmaier, K., 1990, Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor gene, Cytokine 2: 157–161.

    CAS  PubMed  Google Scholar 

  • Fourcin, M., Chevalier, S., Lebrun, J. J., Kelly, P., Pouplard, A., Wijdenes, J., and Gascan, H., 1994, Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor, Eur. J. Immunol. 24: 277–280.

    CAS  PubMed  Google Scholar 

  • Fu, X. Y., and Zhang, J. J., 1993, Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter, Cell 74: 1135–1145.

    CAS  PubMed  Google Scholar 

  • Fu, X. Y., Schindler, C., Improta, T., Aebersold, R., and Darnell, J. J., 1992, The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction, Proc. Natl. Acad. Sci. U.S.A. 89: 7840–7843.

    CAS  PubMed  Google Scholar 

  • Fu, Y. K., Arkins, S., Fuh, G., Cunningham, B. C., Wells, J. A., Fong, S., Cronin, M. J., Dantzer, R., and Kelley, K. W., 1992, Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor, J. Clin. Invest. 89: 451–457.

    CAS  PubMed  Google Scholar 

  • Fuh, G., Cunningham, B. C., Fukunaga, R., Nagata, S., Goeddel, D. V., and Wells, J. A., 1992, Rational design of potent antagonists to the human growth hormone receptor, Science 256: 1677–1680.

    CAS  PubMed  Google Scholar 

  • Fukunaga, R., Ishizaka-Ikeda, E., and Nagata, S., 1990a, Purification and characterisation of the receptor for murine granulocyte colony-stimulating factor, J. Biol. Chem. 265: 14008–14015.

    CAS  PubMed  Google Scholar 

  • Fukunaga, R., Ishizaka-Ikeda, E., Seto, Y., and Nagata, S., 1990b, Expression cloning of a receptor for murine granulocyte colony stimulating factor, Cell 61: 341–350.

    CAS  PubMed  Google Scholar 

  • Fukunaga, R., Ishizaka-Ileda, E., Pan, C.-X., Seto, Y., and Nagata, S., 1991, Functional domains of the granulocyte colony-stimulating factor receptor, EMBO J. 10: 2855–2865.

    CAS  PubMed  Google Scholar 

  • Fukunaga, R., Ishizaka, I. E., and Nagata, S., 1993, Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor, Cell 74: 1079–1087.

    CAS  PubMed  Google Scholar 

  • Galizzi, J. P., Zuber, C. E., Harada, N., Gorman, D. M., Djossou, O., Kastelein, R., Banchereau, J., Howard, M., and Miyajima, A., 1990, Molecular cloning of a cDNA encoding the human interleukin 4 receptor, Im. Immunol. 2: 669–675.

    CAS  Google Scholar 

  • Gately, M. K., Desai, B. B., Wolitky, A. G., Quinn, P. M., Dwer, C. M., Podlaski, F. J., Familletti, P. C., Sinigaglia, F., Chizonnite, R., Guler, U., and Stern, A.S., 1991, Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor), J. Immunol. 147: 874–882.

    CAS  PubMed  Google Scholar 

  • Gearing, D. P., and Cosman, D., 1991, Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor [letter], EMBO J. 10: 2839–2848.

    CAS  PubMed  Google Scholar 

  • Gearing, D. P., King, J. A., Gough, N. M., and Nicola, N. A., 1989, Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor, EMBO J. 8: 3667–3676.

    CAS  PubMed  Google Scholar 

  • Gearing, D. P., Thut, C. J., Vanden Bos, T., Gimpel, S. D., Delaney, P. B., King, J., Price, V., Cosman, D., and Becmann, M. P., 1991, Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130, EMBO J. 10: 2839–2848.

    CAS  PubMed  Google Scholar 

  • Gearing, D. P., Comeau, M.R., Friend, D. J., Gimpel, S. D., Thut, C. J., McCourty, J., King, J. A., Gillis, S., Mosley, B., Ziegler, S. F., and Cosman, D., 1992, The IL-6 signal transducer gp130: An oncostatin M receptor and affinity converter for the LIF receptor, Science 255: 1434–1437.

    CAS  PubMed  Google Scholar 

  • Gearing, D. P., Ziegler, S. F., Comeau, M. R., Friend, D., Thoma, B., Cosman, D., Park, L., and Mosley, B., 1994, Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor, J. Biol. Chem. 269: 6215–6222.

    PubMed  Google Scholar 

  • Giri, J. G., Ahdieh, M., Eisenman, J., Shanebeck, K., Grabstein, K., Kumaki, S., Namen, A., Park, L. S., Cosman, D., and Anderson, D., 1994a, Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15, EMBO J. 13: 2822–2830.

    CAS  PubMed  Google Scholar 

  • Giri, J. G., Grabstein, K., Abdieh, M., Eisenman, J., Paxton, R., Shanebeck, K., Park, L., Satoru, K., Cosman, D., and Anderson, D., 1994b, A novel T cell factor, IL-15 shares both the beta and gamma subunits of the IL-2 receptor, Cytokine 5: 553.

    Google Scholar 

  • Goodall, G. J., Bagley, C. J., Vadas, M. A., and Lopez, A. F., 1993, A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands, Growth Factors 8: 87–97.

    CAS  PubMed  Google Scholar 

  • Goodwin, R. G., Friend, D., Ziegler, S. F., Jerzy, R., Falk, B. A., Gimpel, S., Cosman, D., Dower, S. K., March, C. J., Namen, A. E. and Park, L. S., 1990, Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily, Cell 60: 941–951.

    CAS  PubMed  Google Scholar 

  • Gorman, D. M., Itoh, N., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Miyajima, A., 1992. Chromosomal localization and organization of the murine genes encoding the 3 subunits (AIC2A and AIC2B) of the interleukin 3 granulocyte/macrophage colony-stimulating factor, and interleukin 5 receptors, J. Biol. Chem. 267: 15842–15848.

    CAS  PubMed  Google Scholar 

  • Graham, G. J., and Pragnell, I. B., 1990, Negative regulators of haemopoiesis— current advances, Prog. Growth Factor Res. 2: 181–192.

    CAS  PubMed  Google Scholar 

  • Greenlund, A. C., Schreiber, R. D., Goeddel, D. V., and Pennica, D., 1993, Interferon-gamma induces receptor dimerization in solution and on cells, J. Biol. Chem. 268: 18103–18110.

    CAS  PubMed  Google Scholar 

  • Guba, S. C., Sartor, C. A., Hutchinson, R., Boxer, L. A., and Emerson, S. G., 1994, Granulocyte colony-stimulating factor (G-CSF) production and G-CSF receptor structure in patients with congenital neutropenia, Blood 83: 1486–1492.

    CAS  PubMed  Google Scholar 

  • Hall, A. K., and Rao, M. S., 1992, Cytokines and neurokines: Related ligands and related receptors, Prog. Growth Factor Res. 4: 139–155.

    Google Scholar 

  • Hanazono, Y., Chiba, S., Sasaki, K., Mano, H., Miyajima, A., Arai, K., Yazaki, Y., and Hirai, H., 1993a, c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte–macrophage colony-stimulating factor and interleukin-3, EMBO J. 12: 1641–1646.

    Google Scholar 

  • Hanazono, Y., Chiba, S., Sasaki, K., Mano, H., Yazaki, Y., and Hirai, H., 1993b, Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes protooncogene product in human erythropoietinresponsive cells, Blood 81: 3193–3196.

    CAS  PubMed  Google Scholar 

  • Hapel, A. J., Fung, M. C., Mak, N. K., Morris, C., Metcalf, D., and Nicola, N., 1992, Bone marrow cells from A/J mice do not proliterate in interleukin-3 but express normal numbers of interleukin-3 receptors, Br. J. Haematol. 82: 488–493.

    CAS  PubMed  Google Scholar 

  • Hara, T., and Miyajima, A., 1992, Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3) EMBO J 11: 1875–1884.

    CAS  PubMed  Google Scholar 

  • Harada, N., Castle, B. E., Gorman, D. M., Itoh, N., Schreurs, J., Barrett, R. L., Howard, M., and Miyajima, A.,1990, Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding, Proc. Natl. Acad. Sci. U.S.A. 87: 857–861.

    Google Scholar 

  • Hatakeyama, M., Minamoto, S., Uchiyama, T., Hardy, R. R., Yamada, G., and Taniguchi, T., 1985, Reconstitution of functional receptor for human interleukin-2 in mouse cells, Nature 59: 837–845.

    Google Scholar 

  • Hatakeyama, M., Mori, H., Doi, T., and Taniguchi, T., 1989a, A restricted cytoplasmic region of IL-2 receptor beta chain is essential for growth signal transduction but not for ligand binding and internalization, Cell 318: 467–470.

    Google Scholar 

  • Hatakeyama, M., Tsudo, M., Minamoto, S., Kono, T., Doi. T., Miyata, T., Miyasaka, M. and Taniguchi, T., 1989b, Interleukin-2 receptor beta chain gene: Generation of three receptor forms by cloned human alpha and beta chain cDNA’s, Science 244: 551–556.

    CAS  Google Scholar 

  • Hatakeyama, M., Kono, T., Kobayashi, N., Kawahara, A., Levin, S.D., Perlmutter, R. M., and Taniguchi, T., 1991, Interaction of the IL-2 receptor with the src-family kinase p561ck: Identification of novel intermolecular association, Science 252: 1523–1528.

    CAS  PubMed  Google Scholar 

  • Hayashida, K., Kitamura, T., Gorman, D. M., Arai, K., Yokota, T., and Miyajima, A., 1990, Molecular cloning of a second subunit of the receptor for human granulocyte–macrophage colony stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor, Proc. Natl. Acad. Sci. U.S.A. 87: 9655–9659.

    CAS  PubMed  Google Scholar 

  • Heaney, M. L., and Golde, D. W., 1994, Soluble hormone receptors, Blood 82: 1945–1948.

    Google Scholar 

  • Hemmi, S., Bohni, R., Stark, G., Di, M. F., and Aguet, M., 1994, A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells, Cell 76: 803–810.

    CAS  PubMed  Google Scholar 

  • Herington, A. C., Ymer, S., Roupas, P., and Stevenson, J., 1986a, Growth hormone-binding proteins in high-speed cytosols of multiple tissues of the rabbit, Biochim. Biophys. Acta 881: 236–240.

    CAS  PubMed  Google Scholar 

  • Herington, A. C., Stevenson, J., Coulson, L., and Ymer, S., 1986b, Characterization of a soluble prolactin-binding activity in rat liver cytosol, J. Endocrinol. 109: 61–66.

    CAS  PubMed  Google Scholar 

  • Heyworth, C. M., Ponting, I. L. O., and Dexter, T. M., 1988, The response of haemopoietic cells to growth factors: Developmental implications of synergistic interactions, J. Cell. Sci. 91: 239–247.

    CAS  PubMed  Google Scholar 

  • Heyworth, C. M., Hampson, J., Dexter, T. M., Walker, F., Burgess, A. W., Kan, O., Cook, N., Vallance, S. J., and Whetton, A. D., 1991, Development of multipotential haemopoietic stem cells to neutrophils is associated with increased expression of receptor for granulocyte macrophage colony stimulating factor and altered biological responses to GM-CSF during development, Growth Factors 5: 87–98.

    CAS  PubMed  Google Scholar 

  • Heyworth, C. M., Whetton, A. D., Nicholls, S., Zsebo, K., and Dexter, T. M., 1992, Stem cell factor directly stimulates the development of enriched granulocyte—macrophage colony-forming cells and promotes the effects of other colony-stimulating factors, Blood 80: 2230–2236.

    CAS  PubMed  Google Scholar 

  • Heyworth, C. M., Dexter, T. M., Nicholls, S. E., and Whetton, A. D., 1993, Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte—macrophage colony-forming cells, Blood 81: 894–900.

    CAS  PubMed  Google Scholar 

  • Hibi, M., Murakami, M., Saito, M., Hirano, T. Taga, T., and Kishimoto, T., 1990, Molecular cloning and expression of an IL-6 signal transducer, gp 130, Cell 63: 1149–1157.

    CAS  Google Scholar 

  • Hilton, D. J., and Gough, N. M., 1991, Leukemia inhibitory factor: A biological perspective, J. Cell. Biochem. 46: 21–16.

    CAS  PubMed  Google Scholar 

  • Hilton, D. J., Hilton, A. A., Raicevic, A., Rakar, S., Harrison-Smith, M., Gough, N. M., Begley, C. G., Metcalf, D., Nicola, N. A., and Willson, T. A., 1994, Cloning of a murine IL-11 receptor a-chain; requirement for gp130 for high affinity binding and signal transduction, EMBO J 13: 4765–4775.

    CAS  PubMed  Google Scholar 

  • Ho, A. S.-Y., and Moore, K. W., 1994, Interleukin-10 and its receptor, Thee. Immunol. 1: 173–185.

    CAS  Google Scholar 

  • Ho, A. S., Liu, Y., Khan, T. A., Hsu, D. H., Bazan, J. F., and Moore, K. W., 1993, A receptor for interleukin 10 is related to interferon receptors, Proc. Natl. Acad. Sci. U.S.A. 90: 11267–11271.

    CAS  PubMed  Google Scholar 

  • Holmes, W. E., Lee, J. Kuang, W-J., Rice, G. C., and Wood, W. I., 1991, Structure and functional expression of a human interleukin-8 receptor, Science 253: 1278–1282.

    CAS  Google Scholar 

  • Hou, J., Schindler, U., Henzel, W. J., Ho, T. C., Brasseur, M., and McKnight, S.L., 1994, An interleukin-4-induced transcription factor: IL-4 stat, Science 265: 1701–1706.

    CAS  PubMed  Google Scholar 

  • Howard, M. C., Miyajima, A., and Coffman, R., 1993, T-cell derived cytokines and their receptors, in Fundamental Immunology, ( W.E. Paul, ed.), pp. 763–800. Raven Press, New York.

    Google Scholar 

  • Howard, S. T., Chan, Y. S., and Smith, G. L., 1990, Vaccinia virus homologues of the Shope fibroma virus inverted terminal repeat proteins and a discontinuous ORF related to the tumor necrosis factor receptor family, Science 248: 1019–1023.

    Google Scholar 

  • Hunter, T., and Cooper, T. H., 1985, Protein-tyrosine kinases, Annu. Rev. Biochem. 54: 897–930.

    CAS  PubMed  Google Scholar 

  • Ichihara, M., Hara, T., Takagi, M., Cho, L. C., Gorman, D. M., and Miyajima, A., 1995, Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor a subunit gene, EMBO J. 14: 939–950.

    CAS  PubMed  Google Scholar 

  • Idzerda, R. L., March, C. J., Mosely, B., Lyman, S. D., Vanden Bos, T., Gimpel, S. D., Din, W. S., Grabstein, K., Widmer, M. B., Park, L. S., Cosman, D., and Backmann, M. P., 1990, Human interleukin 4 receptor confers biolgoical responsiveness and defines a novel receptor superfamily, J. Exp. Med 171: 861–873.

    CAS  PubMed  Google Scholar 

  • Ihle, J. N., Witthuhn, B., Tang, B., Yi, T., and Quelle, F. W., 1994a, Cytokine receptors and signal transduction in Bailliere’s Clinical Haematology, pp. 17–48, Bailliere Tindall, London.

    Google Scholar 

  • Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., Thierfelder, W. E., Kreider, B., and Silvennoinen, O., 19946, Signaling by the cytokine receptor superfamily: JAKs and STATs, Trends Biochem. Sci. 19: 222–227.

    Google Scholar 

  • Ikebuchi, K., Clark, S. C., Ihle, J. N., Souza, L. M., and Ogawa, M., I988a, Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors, Proc. Natl. Acad. Sci. 85: 3445–3449.

    Google Scholar 

  • Ikebuchi, K., Ihle, J. N., Hirai, Y., Wong, G. G., Clark, S. C., and Ogawa, M., 1988b, Synergistic factors for stem cell proliferation: Further studies of the interleukin-6, and granulocyte colony-stimulating factor, Blood 72: 2007–2014.

    CAS  PubMed  Google Scholar 

  • Ip, N.Y., Nye, S. H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S. J., Yasukawa, K., Kishimoto, T., Anderson, D. J., 1992. CNTF and LIF act on neuronal cells via shared sigtnaling pathways that involve the IL-6 signal transducing receptor component gp130, Cell 69: 1121–1132.

    CAS  PubMed  Google Scholar 

  • Isfort, R. J., and Ihle, J. N., 1990, Multiple hematopoietic growth factors signal through tyrosine phosphorylation, Growth Factors 2: 213–220.

    CAS  PubMed  Google Scholar 

  • Ishizaka, I. E., Fukunaga, R., Wood, W. I., Goeddel, D. V., and Nagata, S., 1993. Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor, Proc. Natl. Acad. Sci. U.S.A. 90: 123–127.

    Google Scholar 

  • Itoh, N., Yonehara, S., Schreurs, J., Gorman, D. M., Maruyama, K., Ishii, A., Yahara, I., Arai, K., and Miyajima, A., 1990, Cloning of an interleukin-3 receptor: A member of a distinct receptor gene family, Science 247: 324–327.

    CAS  PubMed  Google Scholar 

  • Izquierdo, M., and Cantrell, D. A., 1993, Protein tyrosine kinases couple the interleukin-2 receptor to p2lras, Eur J. Immunol. 23: 131–135.

    CAS  PubMed  Google Scholar 

  • Izuhara, K., and Harada, N., 1993, Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2, J. Biol. Chem. 268: 13097–13102.

    CAS  PubMed  Google Scholar 

  • Izuhara, K., Feldman, R. A., Greer, P. and Harada, N., 1994, Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor, J. Biol. Chem. 269: 18623–18629.

    CAS  PubMed  Google Scholar 

  • Jacobson, N. G., Szabo, S. J., Weber, Nordt, R. M., Zhong, Z., Schreiber, R. D., Darnell, J. Jr., and Murphy, K. M., 1995, Interleukin-12 signaling in T helper type 1 (Thl) cells involves tyrosine phosphorylation of signal trandsducer and activator of transcription (STAT) 3 and STAT4, J. Exp. Med. 181: 1755–1762.

    CAS  PubMed  Google Scholar 

  • Johnston, J. A., Kawamura, M., Kirken, R. A., Chen, Y. Q., Blake, T. B., Shibuya, K., Ortaldo, J. R., McVicar, D. W., and O’Shea, J. J., 1994, Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2, Nature 370: 151–153.

    CAS  PubMed  Google Scholar 

  • Jones, S. S., D’ Andrea, A. D., Haines, L. L., and Wong, G. G., 1990, Human erythropoietin receptor: Cloning, expression, and biologic characterization, Blood 76: 31–35.

    CAS  PubMed  Google Scholar 

  • Kan, O., Evans, C. A., and Whetton, A. D., 1992, Cellular events stimulated by myeloid haemopoietic growth factors in Bailliere’s Clinical Haematology (T. M. Dexter and B. I. Lord, eds.), pp. 653–679, Bailliere Tindall, London.

    Google Scholar 

  • Kanakura, Y., Druker, B., Cannistra, S. A., Furukawa, Y., Torimoto, Y. and Griffin, J. D., 1990, Signal transduction of the human granulocyte—macrophage colony-stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins, Blood 76: 706–715.

    CAS  PubMed  Google Scholar 

  • Kashishian, A., Kazlauskas, A., and Cooper, J. A., 1992, Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo, EMBO J. 11: 1373–1382.

    CAS  PubMed  Google Scholar 

  • Kinoshita, T., Yokota, T., Arai, K.-I., and Miyajima, A., 1995, Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors, EMBO J. 14: 266–275.

    CAS  PubMed  Google Scholar 

  • Kishimoto, T., Akira, S., and Taga, T., 1992a, Interleukin-6 and its receptor: A paradigm for cytokines, Science 258: 593–597.

    CAS  PubMed  Google Scholar 

  • Kishimoto, T., Hibi, M., Murakami, M., Narazaki, M., Saito, M. and Taga, T., 1992b, The molecular biology of interleukin 6 and its receptor in Polyfunctional Cytokines: IL-6 and LIF (G. R. Bock, J. Marsh, and K. Widdows, eds.), pp. 6–23, John Wiley Sons, West Sussex.

    Google Scholar 

  • Kitamura, T., Hayashida, K., Sakamaki, K., Yokota, T., Arai, K., and Miyajima, A., 1991a, Reconstitution of functional human granulocyte/macrophage colony-stimulating factor (GM-CSF): Evidence that AIC2B is a subunit of murine GM-CSF receptor, Proc. Natl. Acad. Sci. U.S.A. 88: 5082–5086.

    CAS  PubMed  Google Scholar 

  • Kitamura, T., Sato, N., Arai, K., and Miyajima, A., 1991b, Expression cloning of the human IL-3 receptor cDNA reveals a shared (3 subunit for human IL-3 and GM-CSF receptors, Cell 66: 1165–1174.

    CAS  PubMed  Google Scholar 

  • Kitamura, T., Ogorochi, T., and Miyajima, A., 1994, Multimeric cytokine receptors, Trends Endocrinol. Metab. 5: 8–14.

    CAS  PubMed  Google Scholar 

  • Kobayashi, M. L., Fitz, M., Ryan, M., Hewick, R. M., Clark, S. C., Chan, S., Loudon, R., Sherman, E, Perussia, B., and Trinchieri, G., 1989, Identification and purification of natural killer cell stimulating factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes, J. Exp. Med. 170: 827–845.

    CAS  PubMed  Google Scholar 

  • Koike, K., Ogawa, M., Ihle, J. N., Miyake, T., Shimizu, T., Miyajima, A., Yokota, T. and Arai, K., 1987, Recombinant murine granulocyte-macrophage (GM) colony stimulating factor supports formation of GM and multipotential blast cell colonies in culture: Comparison with the effects of interleukin-3, J. Cell. Physiol. 131: 458–464.

    CAS  PubMed  Google Scholar 

  • Kondo, S., Shimizu, A., Saito, Y., Kinoshita, M., and Honjo, T., 1986, Molecular basis for two different affinity states of the interleukin 2 receptor: Affinity conversion model, Proc. Natl. Acad. Sci. U.S.A. 83: 9026–9029.

    CAS  PubMed  Google Scholar 

  • Kondo, M., Takeshita, T., Ishii, N., Nakamura, M., Watanabe, S., Arai, K., and Sugamura, K., 1993. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4, Science 262: 1874–1877.

    CAS  PubMed  Google Scholar 

  • Kondo, M., Takeshita, T., Higuchi, M., Nakamura, M., Sudo, T., Nishikawa, S., and Sugamura, K., 1994, Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes, Science 263: 1453 1454.

    Google Scholar 

  • Korpelainen, E.I., Gamble, J.R., Smith, W.B., Goodall, G.J., Qiyu, S., Woodcock, J.M., Dottore, M., Vadas, M.A., and Lopez, A.F., 1993, The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration, Exp. Cell. Res. 206: 311–317.

    Google Scholar 

  • Landschulz, K. T., Noyes, A.N., Rogers, O., and Boyer, S. H., 1989, Erythropoietin receptors on murine erythroid colony-forming units: Natural history, Blood 73: 1476–1486.

    CAS  PubMed  Google Scholar 

  • Larsen, A., Davis, T., Curits, B., Gimpel, S., Sims, J. E., Cosman, D., Park, L., Sorensen, E., March, C. J., and Smith, C. A., 1990, Expression cloning of a human granulocyte colony-stimulating factor receptor: A structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains, J. Exp. Med. 172: 1559–1570.

    CAS  PubMed  Google Scholar 

  • Leary, A. G., Zeng, H. Q., Clark, S. C., and Ogawa, M., 1992, Growth factor requirements for survival on Go and entry into the cell cycle of primitive human hemopoietic progenitors, Proc. Natl. Acad. Sci. U.S.A. 89: 40134017.

    Google Scholar 

  • Lehmann, J., Seegert, D., Strehlow, I., Schindler, C., Lohmann, M. M., and Decker, T., 1994, IL-10-induced factors belonging to the p91 family of proteins bind to IFN-gamma-responsive promoter elements, J. Immunol. 153: 165–172.

    CAS  PubMed  Google Scholar 

  • Leonard, W., 1992, The interleukin-2 receptor; structure, functional, intracellular messengers and molecular regulation in Interleukin-2 (J. Waxman and F. Balkwill, eds.), pp. 29–46, Blackwell Scientific Publications, London.

    Google Scholar 

  • Leonard, W. J., Depper, J. M., Crabtree, G. R., Rudikoff, S., Pumphrey, J., Robb, R. J., Kronke, M., Svetlik, P. B., Peffer, N. J., Waldmann, T. A., and Greene, W. C., 1984, Molecular cloning and expression of cDNAs for the human interleukin-2 receptor, Nature 311: 626–631.

    CAS  PubMed  Google Scholar 

  • Leonard, W. J., Depper, J. M., Kanehisa, M., Kronke, M., Peffer, N. J., Svetlik, P. B., Sullivan, M., and Greene, W. C., 1985, Structure of the human interleukin-2 receptor gene, Science 230: 633–639.

    CAS  PubMed  Google Scholar 

  • Leonard, W. J., Noguchi, M., Russell, S. M., and McBride, O. W., 1991, The molecular basis of X-linked severe combined immunodeficiency: The role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c, Cell 66: 9–10.

    Google Scholar 

  • Leonard, W. J., Noguchi, M., Russell, S. M., and McBride, O. W., 1994, The molecular basis of X-linked severe combined immunodeficiency—the role of the interleukin-2 receptor-gamma chain as a common gamma-chain, gamma(c), Immunol. Rev. 138: 61–86.

    CAS  PubMed  Google Scholar 

  • Leung, D. W., Spencer, S. A., Cachianes, G., Hammonds, R. G., Collins, C., Henzel, W. J., Barnard, R., Waters, M. J., and Wood, W. I., 1987, Growth hormone receptor and serum binding protein: Purification, cloning and expression, Nature 330: 537–543.

    CAS  PubMed  Google Scholar 

  • Lev, S., Givol, D., and Yarden, Y., 1992, Interkinase domain of kit contains the binding sites for phosphatidylinositol 3’ kinase, Proc. Natl. Acad. Sci. U.S.A. 89: 678–682.

    CAS  PubMed  Google Scholar 

  • Li, J. P., D’Andrea, A. D., Lodish, H.F., and Baltimore, D., 1990, Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor, Nature 343: 762–764.

    CAS  PubMed  Google Scholar 

  • Lin, H. Y., Wang, X. F., Ng, E. E., Weinberg, R. A., and Lodish, H. F., 1992, Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase [published erratum appears in Cell, 1992, 70(6): following 1068], Cell 68: 775–785.

    CAS  PubMed  Google Scholar 

  • Liu, Y., Wei, S. H., Ho, A. S., deWaal Malefyt, R., and Moore, K. W., 1994, Expression cloning and characterization of a human IL-10 receptor, J. Immunol. 152: 1821–1829.

    CAS  PubMed  Google Scholar 

  • Lopez, A. F., To, L. B., Yang, Y. C., Gamble, J. R., Shannon, M. F., Burns, G. F., Dyson, P. G., Juttner, C. A., Clark, S., and Vadas, M. A., 1987, Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3. Proc. Natl. Acad. Sci. U.S.A. 84: 2761–2765.

    CAS  PubMed  Google Scholar 

  • Lopez, A. E, Eglinton, J.M., Lyons, A. B., Tapley, P. M., To, L. B., Park, L. S., Clark, S. C., and Vadas, M. A., 1990. Human interleukin-3 inhibits the binding of granulocyte–macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity, J. Cell. Physiol. 145: 69–77.

    CAS  PubMed  Google Scholar 

  • Lopez, A. F., Shannon, M. F., Hercus, T., Nicola, N. A., Cambareri, B., Dottore, M., Layton, M. J., Eglinton, L., and Vadas, M. A., 1992, Residue 21 of human granulocyte–macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding, EMBO J. 11: 909–916.

    CAS  PubMed  Google Scholar 

  • Lopez-Casillas, F., Cheifetz, S., Doody, J., Andres, J. L., Lane, W. S., and Massague, J., 1991. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-13 receptor system, Cell 67: 785–795.

    CAS  PubMed  Google Scholar 

  • Lopez-Casillas, F., Wrana, J. L., and Massague, J., 1993, Betaglycan presents ligand to the TGF beta signaling receptor, Cell 73: 1435–1444.

    CAS  PubMed  Google Scholar 

  • Lopez-Casillas, F., Payne, H. M., Andres, J. L., and Massague, J., 1994, Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: Mapping of ligand binding and GAG attachment sites, J. Cell Biol. 124: 557–568.

    CAS  PubMed  Google Scholar 

  • Lord, K. A., Abdollahi, A., Thomas, S. M., De Marco, M., Brugge, J. S., Hoffman-Liebermann, B., and Liebermann, D. A., 1991. Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation, Mol. Cell. Biol. 11: 4371–4379.

    CAS  PubMed  Google Scholar 

  • Lowenthal, J. W., Castle, B. E., Christiansen, J., Schreurs, J., Rennick, D., Arai, N., Hoy, P., Takebe, Y., and Howard, M., 1988, Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells, J. Immunol. 140: 456–464.

    CAS  PubMed  Google Scholar 

  • Lutticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., and Kishimoto, T., 1994, Association of transcription factor APRF and protein kinase Jakl with the interleukin-6 signal transducer gp130, Science 263: 89–92.

    CAS  PubMed  Google Scholar 

  • Maliszewski, C. R., Sato, T. A., Vanden, B. T., Waugh, S., Dower, S. K., Slack, J., Beckmann, M. P., and Grabstein, K. H., 1990, Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro, J. Immunol. 144: 3028–3033.

    CAS  Google Scholar 

  • Mallett, S., and Barclay, A. N., 1991, A new superfamily of cell surface proteins related to the nerve growth factor receptor, Immunol. Today 12: 220–223.

    CAS  PubMed  Google Scholar 

  • Massague, J., 1987, The TGF-13 family of growth and differentiation factors, Cell 49: 437–438.

    CAS  PubMed  Google Scholar 

  • Massague, J., Attisano, L., and Wrana, J. L., 1994, The TGF-beta family and its composite receptors, Trends Cell. Biol. 4: 172–178.

    CAS  PubMed  Google Scholar 

  • Matsushime, H., Roussel, M. F., Ashmun, R. A., and Sherr, C. J., 1991, Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle, Cell 65: 701–713.

    CAS  PubMed  Google Scholar 

  • Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J., and Kato, J. Y., 1994, D-type cyclindependent kinase activity in mammalian cells, Mol. Cell. Biol. 14: 2066–2076.

    CAS  PubMed  Google Scholar 

  • Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., and Lemischka, I. R., 1991, A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell enriched populations, Cell 65: 1143–1152.

    CAS  PubMed  Google Scholar 

  • Merberg, D. M., Wolf, S. F., and Clark, S. C., 1990, Sequence similarity between NKSF and the IL-6/G-CSF family [letter], Cure. Top. Microbiol. Immunol. 166: 13–22.

    Google Scholar 

  • Merlin, G., Falcoff, E., and Aguet, M., 1985,1251-Labelled human interferons alpha, beta and gamma: Comparative receptor-binding data, J Gen. Virol. 66: 1149–1152.

    Google Scholar 

  • Metcalf, D., 1985, The granulocyte/macrophage colony-stimulating factors, Science 229: 16–22.

    CAS  PubMed  Google Scholar 

  • Metcalf, D., 1986, The molecular biology and functions of the granulocyte—macrophage colony-stimulating factors, Blood 67: 257–267.

    CAS  PubMed  Google Scholar 

  • Metcalf, D., and Nicola, N. A., 1991, Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro. Effects of combination with colony-stimulating factors, Proc. Natl. Acad. Sci. U.S.A. 88: 62396243.

    Google Scholar 

  • Minty, A., Chalon, P., Derocq, J. M., Dumont, X., Guillemot, J. C., Kaghad, M., Labit, C., Leplatois, P., Liauzun, P., Miloux, B., and Casellas, P., Loison, G., Lupker, J., Shire, D. Ferrara, P., and Caput, D.,1993, Interleukin-l3 is a new human lymphokine regulating inflammatory and immune responses, Nature 362: 248–250.

    Google Scholar 

  • Mita, S., Tominaga, A., Hitoshi, Y., Honjo, T., Sakamoto, K., Akagi, M., Kikuchi, Y., and Takatsu, K., 1989, Characterization of high-affinity receptors for interleukin5 (IL-5) on IL-5-dependent cell lines, Proc. Natl. Acad. Sci. U.S.A. 86: 2311–2315.

    CAS  PubMed  Google Scholar 

  • Miyajima, A., 1992, Molecular structure of the IL-3, GM-CSF, and IL-5 receptors, Int. J. Cell Clon. 10: 126–134.

    CAS  Google Scholar 

  • Miyajima, A., Kitamura, T., Harada, N., Yokota, T., and Arai, K., 1992, Cytokine receptors and signal transduction, Annu. Rev. Immunol. 10: 295–331.

    CAS  PubMed  Google Scholar 

  • Miyajima, A., Mui, A.L., Ogorochi, T., and Sakamaki, K., 1993. Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5, Blood 82: 1960–1974.

    CAS  PubMed  Google Scholar 

  • Miyazaki, T., Kawahara, A., Fujii, H., Nakagawa, Y., Minami, Y., Liu, Z-J., Oishi, I., Silvennoinen, O., Witthuhn, B. A., Ihle, J. N., and Taniguchi, T., 1994, Functional activation of Jakl and Jak3 by selective association with IL-2 receptor subunits, Science 266: 1045–1047.

    CAS  PubMed  Google Scholar 

  • Miyazawa, K. Hendrie, P. C., Mantel, C., Wood, K., Ashman, L. K., and Broxmeyer, H. E., 1991, Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte—macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein and mitogen-activated protein kinase, Exp. Hematol. 19: 1110–1123.

    CAS  PubMed  Google Scholar 

  • Molineux, G., Pojda, Z., and Dexter, T. M., 1990, A comparison of hematopoiesis in normal and splenectomised mice treated with granuloycyte-colony stimulating factor, Blood 75: 563–569.

    CAS  PubMed  Google Scholar 

  • Moore, K. W., Vieira, P., Fiorentino, D. F., Trounstine, M. L., Khan, T. A., and Mosmann, T. R., 1990, Homology of cytokine synthesis inhbitory factor (IL-10) to the Epstein—Barr virus gene BCRFI [published erratum appears in Science 1990, 250(4980):494], Science 248: 1230–1234.

    CAS  PubMed  Google Scholar 

  • Moore, K. W., O’Garra, A., deWaal Malefyt, R., Vieira, P., and Mosmann, T. R., 1993, Interleukin-10, Annu. Rev. Immunol. 11: 165–190.

    CAS  PubMed  Google Scholar 

  • Mosley, B., Beckmann, M. P., March, C. J., Idzerda, R. L., Gimpel, S. D., VandenBos, T., Friend, D., Alpert, A., Anderson, D., Jackson, J., Wignall, J. M., Smith, C., Gallis, B., Sims, J. E. Urdal, D., Widmer, M. B., Cosman, D., and Park, L. S., 1989, The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms, Cell 59: 335–348.

    CAS  Google Scholar 

  • Mosely, B., Delmus, C., Friend, D., Thoma, B., and Cosman, D., 1994, The oncostatin-M specific receptor: Cloning of a novel subunit related to the LIF receptor, Cytokine 6: 554.

    Google Scholar 

  • Mui, A. L.-F., Wakao, H., O’Farrell, A.-M., Harada, N., and Miyajima, A., 1995, Interleukin-3, granulocyte macrophage colony stimulating factor and interleukin-5 transduce signals through two STATS homologs, EMBO J. 14: 1166–1175.

    CAS  PubMed  Google Scholar 

  • Muller, M., Laxton, C., Briscoe, J., Schindler, C., Improta, T., Darnell, J. J., Stark, G. R., and Kerr, I. M., 1993, Complementation of a mutant cell line: Central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways, EMBO J. 12: 4221–4228.

    CAS  PubMed  Google Scholar 

  • Murakami, M., Hibi, M., Nakagawa, N., Nakagawa, T., Yasukawa, K. Yamanishi, K., Taga, T., and Kishimoto, T., 1990, IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase, J. Exp. Med. 171: 2001–2009.

    Google Scholar 

  • Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T., and Kishimoto, T., 1993, Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family, Science 260: 1808–1810.

    CAS  PubMed  Google Scholar 

  • Murata, Y., Yamaguchi, N., Hitoshi, Y., Tominaga, A., and Takatsu, K., 1990, Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line, Biochem. Biophys. Res. Commun. 173: 1102–1108.

    CAS  PubMed  Google Scholar 

  • Murray, R. Suda, T., Wrighton, N., Lee, F., and Zlotnik, A., 1989, IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets, Int. Immunol. 1: 526–531.

    CAS  Google Scholar 

  • Murray, R., Lee, F., and Chiu, C. P., 1993, The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis, J. Immunol. 151: 2555–2561.

    Google Scholar 

  • Musashi, M., Clark, S. C., Sudo, T., Urdal, D. L., and Ogawa, M., 1991a, Synergistic interactions between interleukin-11 and interlukin-4 in support of proliferation of primitive hematopoietic progenitors of mice, Mol. Cell. Biol. 11: 4371–4379.

    Google Scholar 

  • Musashi, M., Yang, Y. C., Paul, S. R., Clark, S. C., Sudo, T., and Ogawa, M., 1991b, Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture, Blood 78: 1448–1451.

    CAS  PubMed  Google Scholar 

  • Nagata, S., and Fukunaga, R., 1991, Granulocyte colony-stimulating factor and its receptor, Prog. Growth Factor Res. 3: 131–141.

    CAS  PubMed  Google Scholar 

  • Nakajima, K., and Wall, R., 1993, Interleukin-6 signals activating junB and TISII gene transciption in a B-cell hybridoma, Proc. Natl. Acad. Sci. U.S.A. 90: 11924–11928.

    Google Scholar 

  • Nakamura, Y., Russell, S. M., Mess. S. A., Friedmann, M., Erdos, M., Francois, C., Jacques, Y., Adelstein, S., and Leonard, W. J., 1994, Heterodimerization of the IL-2 receptor beta-and gamma-chain cytoplasmic domains is required for signalling, Nature 369: 330–333.

    CAS  Google Scholar 

  • Namen, A. E., Lupton, S., Hjerrild, K., Wignall, J., Mochizuki, D. Y., Schmierer, A., Mosley, B., March, C. J., Urdal, D., Gillis, S., Cosman, D., and Goodwin, R. G., 1988, Stimulation of B-cell progenitors by cloned murine interleukin-7, Nature 333: 571–573.

    CAS  PubMed  Google Scholar 

  • Narazaki, M., Yasukawa, K., Saito, T., Ohsugi, Y., Fukui, H., Koishihara, Y., Yancopoulos, G. D., Taga, T., and Kishimoto, T., 1994a, Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130, J. Exp. Med. 179: 1337–1342.

    Google Scholar 

  • Narazaki, M., Witthuhn, B. A., Yoshida, K., Silvennoinen, O., Yasukawa, K., Ihle, J. N., Kishimoto, T., and Taga, T., 1994b, Activation of JAK2 kinase mediated by the inteuleukin 6 signal transducer gp130, Proc. Natl. Acad. Sci. U.S.A. 91: 2285–2289.

    CAS  PubMed  Google Scholar 

  • Nicola, N. A., 1989, Hemopoietic cell growth factors and their receptors, Annu. Rev. Biochem. 58:45–77. Nicola, N. A., Metcalf, D., Johnson, G. R., and Burgess, A. W., 1979. Separation of functionally distinct human granulocyte—macrophage colony-stimulating factors, Blood 54: 614–627.

    Google Scholar 

  • Nicola, N. A., Metcalf, D., Matsumoto, M., and Johnson, G. R., 1983, Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells, J. Biol. Chem. 258: 9017–9023.

    CAS  PubMed  Google Scholar 

  • Nishinakamura, R., Miyajima, A., and Murray, R., 1995, Mice deficient for the IL-3/GM-CSF/IL-5 receptor exhibit lung pathology and impaired immune resonse while beta IL-3 receptor-deficient mice are normal, Immunity 2: 211–222.

    CAS  PubMed  Google Scholar 

  • Noguchi, M., Yi, H., Rosenblatt, H. M., Filipovich, A. H., Adelstein, S., Modi, W. S., McBride, A. W., and Leonard, W. J., 1993a, Interleukin-2 receptor ry chain mutation results in X-linked severe combined immunodeficiency in humans, Cell 73: 147–157.

    CAS  PubMed  Google Scholar 

  • Noguchi, M., Nakamura, Y., Russell, S. M., Ziegler, S. F., Tsang, M., Cao, X., and Leonard, W. J., 1993b, Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor, Science 262: 1877–1880.

    CAS  PubMed  Google Scholar 

  • O’Farrell, A.-M., Ichihara, M., Mui, A., and Miyajima, A., 1996, Signaling pathways activated in a unique mast cell line where IL-3 supports survival and SCF is required for a proliferative response, Blood 87: 3655–3668.

    PubMed  Google Scholar 

  • Park, L. S., Friend, D., Price, V., Anderson, D., Singer, J., Prickett, K. S., and Urdal, D. L., 1989, Heterogeneity in human interleukin-3 receptors. A subclass that binds human granulocyte/macrophage colony stimulating factor, J. Biol. Chem. 264: 5420–5427.

    CAS  PubMed  Google Scholar 

  • Park, L. S., Martin, U., Sorensen, R., Luhr, S., Morrissey, P. J., Cosman, D., and Larsen, A., 1992, Cloning of the low-affinity murine granulocyte—macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex, Proc. Natl. Acad. Sci. U.S.A. 89: 4295–4299.

    CAS  PubMed  Google Scholar 

  • Patthy, L., 1990. Letter to the editor: Homology of a domain of the growth hormone/prolactin receptor family with type III modules of fibronectin, Cell 61: 13–14.

    CAS  PubMed  Google Scholar 

  • Pennica, D., King, K. L., Chien, K. R., Baker, J. B., and Wood, W. I., 1994, Cardiotrophin-1, a novel cytokine that induces cardiac myocyte hypertrophy, Cytokine 6: 577.

    Google Scholar 

  • Punnonen, J., Aversa, G., Cocks, B. G., McKenzie, A. N., Menon, S., Zurawski, G., de Waal Malefyt, R., and de Vries, J., 1993, Interleukin 13 induces interleukin 4-independent IgG4 and IgE syntehsis and CD23 expression by human B cells, Proc. Natl. Acad. Sci. U.S.A. 90: 3730–3734.

    CAS  PubMed  Google Scholar 

  • Quelle, F. W., Sato, N., Witthuhn, B. A., Inhorn, R. C., Eder, M., Miyajima, A., Griffin, J. D., and Ihle, J. N., 1994, JAK2 associates with the beta c chain of the receptor for granulocyte—macrophage colony-stimulating factors, and its activation requires the membrane-proximal region, Mol. Cell. Biol. 14: 4335–4341.

    CAS  PubMed  Google Scholar 

  • Quesniaux, V. F., Clark, S. C., Turner, K., and Fagg, B., 1991, Interleukin-ll stimulates multiple phases of erythropoiesis in vitro, Proc. Natl. Acad. Sci. U.S.A. 88: 765–769.

    Google Scholar 

  • Ravichandran, K. S., and Burakoff, S. J., 1994, The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation, J. Biol. Chem. 269: 1599–1602.

    CAS  PubMed  Google Scholar 

  • Reedijk, M., Liu, X., Van der Geer, P., Letwin, K., Waterfield, M. D., Hunter, T., and Pawson, T., 1992, Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI3’-kinase SH2 domains: A model for SH2mediated receptor-target interactions, EMBO J. 11: 1365–1372.

    CAS  PubMed  Google Scholar 

  • Renauld, J. C., Kermouni, A., Vink, A., Louahed, J., and Van Snick, J., 1995, Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis, J. Leuk. Biol. 57: 353–360.

    CAS  Google Scholar 

  • Renauld, J. C., Druez, C., Kermouni, A., Houssiau, F., Uyttenhove, C., Van Roost, E., and Van Snick, J., 1992, Expression cloning of the murine and human interleukin 9 receptor cDNAs, Proc. Natl. Acad. Sci. U.S.A. 89: 5690–5694.

    CAS  PubMed  Google Scholar 

  • Rennick, D., Moore, R. G., and Thompson-Snipes, L., 1992, IL-4 and hematopoiesis, in IL-4: Structure and Function ( H. spits, ed.), pp. 151–168, CRC Press, Boca Raton.

    Google Scholar 

  • Robb, R. J., and Rusk, C.M., 1986, High and low affinity receptors for interleukin 2: Implications of pronase, phorbol ester, and cell membrane studies upon the basis for differential ligand affinities, J. Immunol. 137: 142–159.

    CAS  PubMed  Google Scholar 

  • Rode, H.-J., Janssen, W., and Rosen-Wolff, A., 1993, The genome of equine herpesvirus type 2 harbors an interleukin-10 (IL-l0)-like gene, Virus Genes 7: 111–116.

    CAS  PubMed  Google Scholar 

  • Rose, J. S., and Heinrich, P. C., 1994, Soluble receptors for cytokines and growth factors: Generation and biological function, Biochem. J. 300: 281–290.

    Google Scholar 

  • Rose, T. M., and Bruce, A. G., 1992, Oncostatin M is a member of a cytokine family that includes leukemia- inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6, J. Immunol. 149: 1271–1275.

    PubMed  Google Scholar 

  • Rothman, P., Kreider, B., Azam, M., Levy, D., Wegenka, U., Eilers, A., Decker, T., Horn, F., Kashleva, H., Ihle, J., and Schindler, C., 1994, Cytokine and growth factors signal through tyrosine phosphorylation of a family of related transcription factors, Immunity 1: 1–20.

    Google Scholar 

  • Roussel, M. F., Dull, J. F., Rettenmier, C. W., Ralph, P., Ullrich, A., and Sherr, C.J., 1987, Transforming potential of the c fins proto-oncogene product, Nature 325: 549–550.

    CAS  PubMed  Google Scholar 

  • Roussel, M. F., Downing, J. R., Rettenmier, C. W., and Sher, C. J., 1988, A point mutation in the extracellular domain of the human CSF-1 receptor (c -fins) proto-oncogene product activates its transforming potential, Cell 55: 979–988.

    CAS  PubMed  Google Scholar 

  • Ruscetti, T. W., Dubois, C., Falk, L. A., Jacobsen, S. E., Sing, G., Longo, D. L., Wiltrout, R. H., and Keller, J. R., 1991, Clinical applications of TFG-ß. In vivo and in vitro effects of TGF- 3l on normal and neoplastic haemopoiesis, in Ciba Foundation Symposium 157 (R. Gregory Bock and J. Marsh, eds.), pp. 212–231, John Wiley Son, New York.

    Google Scholar 

  • Russell, S. M., Keegan, A. D., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedmann, M. C., Miyajima, A., Puri, R. K., Paul, W. E., and Leonard, W. J., 1993, Interleukin-2 receptor gamma chain: A functional component of the interleukin-4 receptor, Science 262: 1880–1883.

    CAS  PubMed  Google Scholar 

  • Russell, S. M., Johnston, J. A., Noguchi, M., Kawamura, M., Bacon, C. M., Friedmann, M. Berg, M., McVicar, W., Witthuhn, B.A.; Silvennoinen, O., Goldman, A. S., Schmalsteig, F. C., Ihle, J., O’Shea, J., and Leonard, W. J., 1994, Interaction of IL-2R beta and gamma-c chains with JAKI and JAK3: Implications for XSCID and XCID, Science 266: 1042–1045.

    Google Scholar 

  • Sakamaki, K., Miyajima, I., Kitamura, T., and Miyajima, A., 1992, Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, I1–3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation, EMBO J. 11: 3541–3549.

    CAS  PubMed  Google Scholar 

  • Sanderson, C. J., 1992, Interleukin-5, eosinophils, and disease, Blood 79: 3101–3109.

    CAS  PubMed  Google Scholar 

  • Sato, N., Caux, C., Kitamura, T., Watanabe, Y., Arai, K., Banchereau, J., and Miyajima, A., 1993a, Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells, Proc. Natl. Acad. Sci. U.S.A. 90: 11137–11141.

    Google Scholar 

  • Sato, N., Sakamaki, K., Terada, N., Arai, K., and Miyajima, A., 1993b, Signal transduction by the high-affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common beta subunit responsible for different signaling, EMBO J. 12: 4181–4189.

    CAS  PubMed  Google Scholar 

  • Satoh, T., Minami, Y., Kono, T., Yamada, K., Kawahara, A., Taniguchi, T., and Kaziro, Y., 1992a, Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lek-binding domain, J. Biol. Chem. 267: 25423–25427.

    CAS  PubMed  Google Scholar 

  • Satoh, T., Uehara, Y., and Kaziro, Y., 1992b, Inhibition of interleukin 3 and granulocyte—macrophage colony-stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases, J. Biol. Chem. 267: 2537–2541.

    CAS  PubMed  Google Scholar 

  • Schindler, C., Fu, X. Y., lmprota, T., Aebersold, R., and Darnell, J. J., 1992a. Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha, Proc. Natl. Acad. Sci. U.S.A. 89: 7836–7839.

    CAS  PubMed  Google Scholar 

  • Schindler, C., Shuai, K., Prezioso, V. R., and Darnell, J.J., 1992b, Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor [see comments], Science 257: 809–813.

    CAS  PubMed  Google Scholar 

  • Schooltink, H., Stoyan, T., Roeb, E., Heinrich, P. C., and Rose, J. S., 1992, Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes, New Biol. 4: 61–65.

    Google Scholar 

  • Schorle, H., Holtschke, T., Hunig, T., Schimpl, A., and Horak, I.. 1991, Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting, Nature 352: 621–624.

    CAS  PubMed  Google Scholar 

  • Schrader, J.W., 1986, The panspecific hemopoietin of activated T lymphocytes (interleukin-3), Annu. Rev. Immunol. 4: 205–230.

    CAS  PubMed  Google Scholar 

  • Shanafelt, A. B., and Kastelein, R. A., 1992, High affinity ligand binding is not essential for granulocyte—macrophage colony-stimulating factor receptor activation, J. Biol. Chem. 267: 25466–25472.

    CAS  PubMed  Google Scholar 

  • Shanafelt, A. B., Miyajima, A., Kitamura, T., and Kastelein, R. A., 1991, The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors, EMBO J. 10: 4105–4112.

    CAS  PubMed  Google Scholar 

  • Shearman, M. S., Heyworth, C. M., Dexter, T. M., Haefner, B., Owen, P. J., and Whetton, A. D., 1993, Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies, J. Cell Sci. 104: 173–180.

    CAS  PubMed  Google Scholar 

  • Sherr, C. J., 1990, Review, colony-stimulating factor-I receptor, Blood 75: 1–12.

    CAS  PubMed  Google Scholar 

  • Sherr, C. J., 1993, Mammalian GI cyclins, Cell 73: 1059–1065.

    CAS  PubMed  Google Scholar 

  • Shuai, K., Schindler, C., Prezioso, V. R., and Darnell, J. J., 1992, Activation of transcription by IFN-gamma: Tyrosine phosphorylation of a 91-kD DNA binding protein, Science 258: 1808–1812.

    CAS  PubMed  Google Scholar 

  • Shuai, K., Ziemiecki, A., Wilks, A. F., Harpur, A. G., Sadowski, H. B., Gilman, M. Z., and Darnell, J. E., 1993a, Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins, Nature 366: 580–583.

    CAS  PubMed  Google Scholar 

  • Shuai, K., Stark, G. R., Kerr, I. M., and Darnell, J. J., 1993b, A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma, Science 261: 1744–1746.

    CAS  PubMed  Google Scholar 

  • Shuai, K., Horvath, C. M., Huang, L. H., Qureshi, S. A., Cowbum, D., and Darnell, J. J., 1994, Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions, Cell 76: 821–828.

    CAS  PubMed  Google Scholar 

  • Sims, J. E., March, C. J., Cosman, D., Wimder, M. B., MacDonald, H. R., McMahan, C. J., Grubin, C. E., Wignall, J. M., Jackson, J. L., Call, S. M., Friend, D., Albert, A. L., Gillis, S., Urdal, D., and Dower, S. K., 1988, cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily, Science 241: 585–589.

    Google Scholar 

  • Smith, C. A., Davis, T., Wignall, J. M., Din, W. S., Farrah, T., Upton, C., McFadden, G., and Goodwin, R. G., 1990, T2 open reading frame from the Shope fibroma virus encodes a soluble form of the TNF receptor, Science 248: 1019–1023.

    CAS  PubMed  Google Scholar 

  • Soh, J., Donnelly, R. J., Kotenko, S., Mariano, T. M., Cook, J. R., Wang, N., Emanuel, S., Schwartz, B., Miki, T., and Pestka, S., 1994, Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor, Cell 76: 793–802.

    CAS  PubMed  Google Scholar 

  • Sorensen, P., Mui, A. L., and Krystal, G., 1989, Interleukin-3 stimulates the tyrosine phosphorylation of the 140kilodalton interleukin-3 receptor, J. Biol. Chem. 264: 19253–19258.

    CAS  PubMed  Google Scholar 

  • Sprang, S. R., and Bazan, J. F., 1993, Cytokine structural taxonomy and mechanisms of receptor engagement, Cure. Opin. Struct. Biol. 3: 815–827.

    CAS  Google Scholar 

  • Stahl, N., Davis, S., Wong, V., Taga, T. Kishimoto, T., Ip, N. Y., and Yancopoulos, G. D., 1993, Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component, Science 260: 1805–1808.

    Google Scholar 

  • Stahl, N. Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., Ihle, J. N., and Yancopoulos, G. D., 1994, Association and activation of Jak—Tyk kinases by CNTF—LIF—OSM—IL-6 beta receptor components, Science 253: 92–95.

    Google Scholar 

  • Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. Jr., and Yancopoulos, G. D., 1995, Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors, Science 267: 1349–1353.

    CAS  PubMed  Google Scholar 

  • Stanley, E., Lieschke, G. J., Grail, D., Metcalf, D. Hodgson, G., Gall, J. A., Maher, D. W., Cebon, J., Sinickas, V., and Dunn, A. R., 1994, Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology, Proc. Natl. Acad. Sci. U.S.A. 91: 5592–5596.

    CAS  Google Scholar 

  • Suematsu, S., Hibi, M., Sugita, T., Saito, M., Murakami, M., Matsusaka, T., Matsuda, T., Hirano, T., Taga, T., and Kishimoto, T., 1990, Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma, J. Exp. Med. 171: 2001–2009.

    Google Scholar 

  • Sugita, T., Totsuka, T., Saito, M., Yamasaki, K., Taga, T., Hirano, T., and Kishimoto, T., 1993, Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis, EMBO J. 12: 1705–1712.

    Google Scholar 

  • Taga, R., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., and Kishimoto, T., 1989, Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130, Cell 58: 573–581.

    CAS  PubMed  Google Scholar 

  • Takagi, M., Hara, T., Ichihara, M., Takatsu, K., and Miyajima, A., 1995, Multi-colony stimulating activity of interleukin-5 (IL-5) on hematopoietic progenitors from trangenic mice that express IL-5 receptor a subunit constitutively,. 1. Exp. Med. 181: 889–899.

    CAS  Google Scholar 

  • Takaki, S., Mita, S., Kitamura, T., Yonehara, S., Yamaguchi, N., Tominaga, A., Miyajima, A., and Takatsu, K., 1991, Identification of the second subunit of the murine interleukin-5 receptor: Interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor, EMBO J. 10: 2833–2838.

    CAS  PubMed  Google Scholar 

  • Takaki, S., Kanazawa, H., Shiiba, M., and Takatsu, K., 1994, A critical domain of the interleukin-5 (IL-5) receptor a chain and its function in IL-S-mediated growth signal transduction, Mol. Cell. Biol. 14: 7404–7413.

    CAS  PubMed  Google Scholar 

  • Takeshita, T., Ohtani, K., Asao, H., Kumaki, S., Nakamura, M., and Sugamura, K., 1992a, An associated molecule, p64, with II-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity 1L-2 receptor complex, J. Immunol. 148: 2154–2158.

    CAS  PubMed  Google Scholar 

  • Takeshita, T., Asao, H. Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M., and Sugamura, K., 1992b, Cloning of the gamma chain of the human IL-2 receptor, Science 257: 379–382.

    CAS  Google Scholar 

  • Tamura, T., Udagawa, N., Takahashi, N., Miyaura, C., Tanaka, S., Yamada, Y., Koishihara, Y., Ohsugi, Y., Kumaki

    Google Scholar 

  • K., Taga, T., and Kishimoto, T., 1991, Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6, Proc. Natl. Acad. Sci. U.S.A. 88: 11349–11353.

    Google Scholar 

  • Taniguchi, T., and Miniami, Y., 1993, The IL-2/IL-2R system: A current overview, Cell 73: 5–8.

    CAS  PubMed  Google Scholar 

  • Tavernier, J., Devos, R., Cornelis, S., Tuypena, T., Van der Heyden, J., Fiers, W., and Plaetinck, G., 1991, A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5 specific a chain and a 3 chain shared with the receptor for GM-CSF, Cell 66: 1175–1184.

    CAS  PubMed  Google Scholar 

  • Tian, S. S., Lamb, P., Seidel, H. M., Stein, R. B., and Rosen, J., 1994, Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor, Blood 84: 1760–1764.

    CAS  PubMed  Google Scholar 

  • Ullrich, A., and Schlessinger, J., 1990, Signal transduction by receptors with tyrosine kinase activity, Cell 61: 203–212.

    CAS  PubMed  Google Scholar 

  • Upton, C., Mossman, K., and McFadden, G., 1992, Encoding of a homolog of the IFN-gamma receptor by myxoma virus, Science 258: 1369–1372.

    CAS  PubMed  Google Scholar 

  • Urdal, D. L., and Park, L. S., 1988, Studies on hematopoietic growth factor receptors using human recombinant IL-3, GM-CSF, G-CSF, M-CSF, IL-1, and IL-4, Behring Inst. Mitt. 83: 27–39.

    CAS  PubMed  Google Scholar 

  • Uyttenhove, C., Simpson, R. J., and Van Snick, J., 1988, Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity, Proc. Natl. Acad. Sci. U.S.A. 85: 6934–6938.

    CAS  PubMed  Google Scholar 

  • Uze, G., Lutfalla, G., and Gresser, I., 1990, Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA, Cell 60: 225–234.

    CAS  PubMed  Google Scholar 

  • Vadas, M. A., Nicola, N. A., and Metcalf, D., 1983, Activation of antibody dependent cell-mediated cytotoxicity of human neutrophils and eosinophils by separate colony stimulating factors, J. Immunol. 130: 795–799.

    CAS  PubMed  Google Scholar 

  • Vanden, B. C., and Pfeffer, L. M., 1988, Characterization of interferon-alpha binding sites on human cell lines, J. Interferon Res. 8: 803–811.

    Google Scholar 

  • Velazquez, L., Fellous, M., Stark, G. R., and Pellegrini, S.,1992, A protein tyrosine kinase in the interferon alpha/ beta signaling pathway, Cell 70: 313–322.

    Google Scholar 

  • Voss, S. D., Sondel, R. M., and Robb, R. J., 1992, Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: Association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R, J. Exp. Med. 176: 531–541.

    CAS  PubMed  Google Scholar 

  • Voss, S. D., Leary, T. P., Sondel, P. M., and Robb, R. J., 1993, Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain, Proc. Natl. Acad. Sci. U.S.A. 90: 2428–2432.

    CAS  PubMed  Google Scholar 

  • Wakao, H., Schmitt-N. M., and Groner, B., 1992, Mammary-gland specific factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89kDa, J. Biol. Chem. 267: 16365–16370.

    CAS  Google Scholar 

  • Wakao, H., Gouilleux, F., and Groner, B., 1994, Mammary gland factor (MGF) is a novel family of the cytokine regulated transcription factor gene family and confers the prolactin response, EMBO J. 13: 2182–2191.

    CAS  PubMed  Google Scholar 

  • Wakao, H., Harada, N., Kitamura, T., Mui, A. L., and Miyajima. A., 1995, Interleukin-2 and erythropoietin activate STAT5IMGF via distinct pathways, EMBO J. 14: 2527–2535.

    CAS  PubMed  Google Scholar 

  • Watling, D., Guschin, D., Muller, M., Silvennoinen, O., Witthuhn, B. A., Quelle, F. W., Rogers, N. C., Schindler, C., Stark, G. R., Ihle, J. N., and Kerr, I. M., 1993, Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway, Nature 366: 166–170.

    CAS  PubMed  Google Scholar 

  • Watowich, S. S., Yoshimura, A., Longmore, G. D., Hilton, D. J., Yoshimura, Y., and Lodish, H. F., 1992, Homodimerization and constitutive activation of the erythropoietin receptor, Proc. Natl. Acad. Sci. U.S.A. 89: 2140–2144.

    CAS  PubMed  Google Scholar 

  • Weinberg, K., and Parkman, R., 1990, Severe combined immunodeficiency due to a specific defect in the production of interleukin-2, N. Engl. J. Med. 322: 1718–1723.

    CAS  PubMed  Google Scholar 

  • Weiser, W. Y., Van Niel, A., Clark, S. C., Dard, J. R., and Remold, H. J., 1987, Recombinant human granulocyte/ macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages, J. Exp. Med. 166: 1436–1446.

    CAS  PubMed  Google Scholar 

  • Weissman, C., and Weber, H., 1986, The interferon genes. Prog. Nucleic Acid Res. 33: 251–300.

    Google Scholar 

  • Welham, M. J., and Schrader, J. W., 1992, Steel factor-induced tyrosine phosphorylation in murine mast cells. Common elements with IL-3-induced signal transduction pathways, J. Immunol. 149: 2772–2783.

    CAS  PubMed  Google Scholar 

  • Welham, M. J., Duronio, V., Sanghera, J. S., Pelech, S. L., and Schrader, J. W., 1992, Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members, J. Immunol. 149: 1683–1693.

    CAS  PubMed  Google Scholar 

  • Wheeler, E. F., Rettenmier, C. W., Look, A. T., and Sherr, C. J., 1986, The v-fins oncogene induces factor independence and tumorigenicity in CSF-1-dependent macrophage cell line, Nature 324: 377–380.

    CAS  PubMed  Google Scholar 

  • Wilks, A. F., 1990, Structure and function of the protein tyrosine kinases, Prog. Growth Factor Res. 2: 97–111.

    CAS  PubMed  Google Scholar 

  • Winkelmann, J. C., Penny, L. A., Deaven, L. L., Forget, B. G., and Jenkins, R. B., 1990, The gene for the human erythropoietin receptor: Analysis of the coding sequence and assignment to chromosome 19p, Blood 76: 24–30.

    CAS  PubMed  Google Scholar 

  • Witthuhn, B., Quelle, E W., Silvennoinen, O., Yi, T., Tang, B., Miura, O., and Ihle, J. N., 1993, JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following EPO stimulation, Cell 74: 227–236.

    CAS  PubMed  Google Scholar 

  • Witthuhn, B. A., Silvennoinen, O., Miura, O., Lai, K. S., Cwik, C., Liu, E. T., and Ihle, J. N., 1994, Involvement of the Jak-3 Janus kinase in signalling by interleukine 2 and 4 in lymphoid and myeloid cells, Nature 370: 153–157.

    CAS  PubMed  Google Scholar 

  • Woodcock, J. M., Zacharakis, B., Plaetinck, G., Bagley, C. J., Qiyu, S., Hersuc, T. R., Tavernie, R. J., and Lopez, A. F., 1994, Three residues in the common 13 chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 high affinity binding but not IL-3 high affinity binding and interact with G1u21 of GMCSF, EMBO J. 13: 5176–5185.

    CAS  PubMed  Google Scholar 

  • Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., and Massague, J., 1994, Mechanism of activation of the TGF-beta receptor, Nature 370: 341–347.

    CAS  PubMed  Google Scholar 

  • Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Hawanishi, Y., Seed, B., Taniguchi, T., Hirano, T., and Kishmoto, T., 1988, Cloning and expression of the human interleukin-6 (BSF-2/IFNB2) receptor, Science 241: 825–828.

    CAS  PubMed  Google Scholar 

  • Yang, Y. C., Tsai, S., Wong, G. G., and Clark, S. C., 1988, Interleukin-1 regulation of hematopoietic growth factor production by human stromal fibroblasts, J. Cell Physiol. 134: 292–296.

    CAS  PubMed  Google Scholar 

  • Yi, T., Mui, A. L., Krystal, G., and Ihle, J. N., 1993, Hematopoietic cell phosphatase associates with the interleukin-3 (IL 3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis, Mol. Cell. Biol. 13: 7577–7586.

    CAS  PubMed  Google Scholar 

  • Yin, T., and Yang, Y. C., 1994, Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-Il, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3–L1 cells, J. Biol. Chem. 269: 3731–3738.

    CAS  PubMed  Google Scholar 

  • Yin, T., Taga, T., Tsang, M.L., Yasukawa, K., Kishimoto, T., and Yang, Y. C., 1992, Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction, J. Biol. Chem. 267: 10238–10247.

    Google Scholar 

  • Yin, T., Yasukawa, K., Taga, T., Kishimoto, T., and Yang, Y. C., 1994, Identification of a 130-kilodalton tyrosinephosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase, which associates with gp130 signal transducer, Exp. Hematol_ 22: 467–472.

    CAS  PubMed  Google Scholar 

  • Yoshimura, A., Immers, T., and Neumann, D., Longmore, G., Yoshimura, Y., and Lodish, H. F., 1992, Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor, J. Biol. Chem. 267: 11619–11625.

    CAS  Google Scholar 

  • Zhong, A., Wen, Z., and Darnell, J. J., 1994, Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6, Science 264: 95–98.

    CAS  PubMed  Google Scholar 

  • Zurawski, S. M., Vega, F. J., Huyghe, B., and Zurawski, G., 1993, Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction, EMBO J. 12: 2663–2670.

    CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Taisei Kinoshita & Atsushi Miyajima

    Present address: Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan

Authors and Affiliations

  1. DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California, 94304, USA

    Anne-Marie O’Farrell, Taisei Kinoshita & Atsushi Miyajima

Authors
  1. Anne-Marie O’Farrell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Taisei Kinoshita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Atsushi Miyajima
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Leukaemia Research Fund Cellular Development Unit, UMIST, Manchester, England

    Anthony D. Whetton

  2. The Medical School, University of Birmingham, Birmingham, England

    John Gordon

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

O’Farrell, AM., Kinoshita, T., Miyajima, A. (1996). The Hematopoietic Cytokine Receptors. In: Whetton, A.D., Gordon, J. (eds) Blood Cell Biochemistry. Blood Cell Biochemistry, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-31728-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-0-585-31728-1_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-7052-0

  • Online ISBN: 978-0-585-31728-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation