T-Lymphocyte Genes


Antigen-specific receptors on T lymphocytes are generated by the rearrangement of germline DNA to produce immunoglobulinhke receptor molecules. Unlike the immunoglobulin receptors on B cells, however, T cells do not secrete antigen-specific molecules but rather express them only on the cell surface. Furthermore, unlike immunoglobulins, which can recognize virtually any form of antigen, be it on the cell surface, soluble in the plasma, protein, or carbohydrate, the T-cell receptor (TCR) recognizes protein antigen that is processed into peptides and complexed together with class I or class 11 molecules on the cell surface. Thus, T cells must be capable of “reading” and interpreting class I/lI-peptide complexes, and be capable of determining if these complexes indicate that trouble is lurking within the cell. This remarkable ability of T cells to analyze the actual contents of cells defines their role as highly specialized detectives capable of routing our intracellular pathogens. Once cells harboring intracellular pathogens are discovered, T cells can differentiate specific cytotoxic activity and destroy infected cells.


Antigen Receptor Cell Antigen Receptor Gamma Delta Variable Region Gene Alpha Beta 


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