Blood is the medium in which all drugs are transported to and from all tissues of the body. The rate at which blood enters and leaves any tissue is directly related to cardiac output. This means that cardiac output is an important determinant of drug kinetics. Cardiac output changes with age, psychological state, activity level, drugs and disease. This chapter discusses the effects of physiological and pathological changes of cardiac output on the kinetics and dynamics of drugs used in anesthesia.
KeywordsCardiac Output Circulation Time Hepatic Blood Flow Tissue Blood Flow Pulmonary Blood Volume
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