Plasma Protein Binding

  • Gerald M. Woerlee
Part of the Developments in Critical Care Medicine and Anesthesiolgy book series (DCCA, volume 26)


Drugs used in anesthesia are all bound to a greater or lesser degree to plasma proteins. Plasma protein binding of drugs has a significant effect on their kinetics and dynamics. Variations of normal physiology and diseases affect both the concentrations and affinity of plasma proteins for drugs. This chapter provides a brief discussion of the relevance of plasma protein drug binding to kinetics and dynamics.


Plasma Protein Binding Plasma Drug Concentration Free Fraction Extracellular Fluid Volume Protein Drug Binding 
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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Gerald M. Woerlee
    • 1
  1. 1.Rijnoord HospitalAlphen aan den RijnThe Netherlands

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