Plasma Protein Binding
Drugs used in anesthesia are all bound to a greater or lesser degree to plasma proteins. Plasma protein binding of drugs has a significant effect on their kinetics and dynamics. Variations of normal physiology and diseases affect both the concentrations and affinity of plasma proteins for drugs. This chapter provides a brief discussion of the relevance of plasma protein drug binding to kinetics and dynamics.
KeywordsPlasma Protein Binding Plasma Drug Concentration Free Fraction Extracellular Fluid Volume Protein Drug Binding
Unable to display preview. Download preview PDF.
- 1.Wood M: Plasma drug binding: Implications for anesthesiologists. Anesthesiology, 1986: 65: 786–804.Google Scholar
- 4.Woerlee GM, “Common Perioperative Problems and the Anaesthetist”, published Kluwer Academic Publishers, 1988, ISBN 0-89838-402-8, pages 508–510.Google Scholar
- 5.Lemmens HJM, et al: Pharmacodynamics of alfentanil: The role of plasma protein binding. Anesthesiology, 1989, (submitted for publication)Google Scholar
- 9.Rowland M, Tozer TN: “Clinical Pharmacokinetics. Concepts and Applications”, published by Lea & Febiger, USA, 1980, ISBN 0-8121-0681-4.Google Scholar